Researchers at Oxford University’s Wellcome Trust Centre for Human Genetics have located a variant form of a polynucleotide sequence in the MHC region of chromosome 6p and identified its association with an increased secretion of TNF. Potential applications for this discovery include the diagnosis of asthma in patients, or a predisposition to asthma, and a patients’ suitability for treatment with anti-TNF therapy.
Asthma is a disease in which the airways become inflamed leading to blockage and narrowing, with resultant symptoms including wheezing, coughing, shortness of breath and tightening of the chest. Asthma sufferers can be of any race, age or sex, and over 17 million people in the United States alone suffer from the disease.
Most asthma is initiated by an IgE mediated allergy (atopy) to inhaled environmental allergens, including pollen, air pollutants and irritants. The susceptibility to asthma is strongly familial, and is due to both genetic and environmental factors. The identification of other genetic factors will lead to further understanding of susceptibility to asthma and an ability to develop a pharmacogenomic approach to treatment, new therapeutic approaches to treat sub-groups of patients who will benefit most from them. Tumour necrosis factor (TNF) is a potent pro-inflammatory cytokine that is found in increased concentrations in asthmatic airways and in lavage fluid from asthmatic lungs.
Jennifer Johnson | alfa
3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg
Better equipped in the fight against lung cancer
16.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg
So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics
Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...
The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...
A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.
The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...
Cardiovascular tissue engineering aims to treat heart disease with prostheses that grow and regenerate. Now, researchers from the University of Zurich, the Technical University Eindhoven and the Charité Berlin have successfully implanted regenerative heart valves, designed with the aid of computer simulations, into sheep for the first time.
Producing living tissue or organs based on human cells is one of the main research fields in regenerative medicine. Tissue engineering, which involves growing...
A team of scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg investigated optically-induced superconductivity in the alkali-doped fulleride K3C60under high external pressures. This study allowed, on one hand, to uniquely assess the nature of the transient state as a superconducting phase. In addition, it unveiled the possibility to induce superconductivity in K3C60 at temperatures far above the -170 degrees Celsius hypothesized previously, and rather all the way to room temperature. The paper by Cantaluppi et al has been published in Nature Physics.
Unlike ordinary metals, superconductors have the unique capability of transporting electrical currents without any loss. Nowadays, their technological...
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