Amphidinolides, a family of natural compounds that have shown promise as powerful antitumor agents, pose problems for cancer researchers because they are found in only minute amounts, and only in microscopic marine flatworms that live off the coasts of Japan and the U.S. Virgin Islands. Nature keeps a tight lock on its supply of amphidinolide.
Work by University of Illinois at Chicago chemistry professor Arun Ghosh may solve this problem. Hes successfully developed a way to synthesize amphidinolides, making potentially abundant quantities available for cancer research. Ghosh and doctoral student Chunfeng Liu reported on their technique in the Feb. 6 online edition of the Journal of the American Chemical Society.
"We wanted to synthesize amphidinolide in the laboratory for subsequent biological studies," said Ghosh. As an antitumor agent, "nobody knows its exact mechanism of action. It could be a microtubule stabilizing agent, like Taxol, or it could cause cellular apopotosis, where cancer cells are killed by chemotherapeutic agents," he said.
Paul Francuch | EurekAlert!
A 'half-hearted' solution to one-sided heart failure
24.11.2017 | Boston Children's Hospital
New study points the way to therapy for rare cancer that targets the young
22.11.2017 | Rockefeller University
High-precision measurement of the g-factor eleven times more precise than before / Results indicate a strong similarity between protons and antiprotons
The magnetic moment of an individual proton is inconceivably small, but can still be quantified. The basis for undertaking this measurement was laid over ten...
Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...
The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.
Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....
The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.
Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...
Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.
That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...
15.11.2017 | Event News
15.11.2017 | Event News
30.10.2017 | Event News
24.11.2017 | Physics and Astronomy
24.11.2017 | Health and Medicine
24.11.2017 | Earth Sciences