Personalised doses of insulin
Diabetes is a widespread illness affecting 5 per cent of the population. In diabetics the metabolism produces an excess of glucose in the blood and, as a result, a number of sufferers need doses of insulin which allows them to regulate their glucose levels.
Currently, the method of administering insulin to diabetic patients making use of emergency services for insulin dosage depends on the experience of the qualified personnel. That is, the same patient can receive different insulin doses, and in different ways, according to the doctor attending her or him.
In order to improve this system of administration, Doctor Tomás Rubio proposed in his doctoral thesis the development of a mathematical model which would facilitate predicting the exact amount of insulin needed by a patient at any time. The thesis showed that both the absorption constant (the time taken for the insulin to enter the blood and become effective) as well as the elimination constant (the time taken for the insulin to disappear), is different for each patient. Moreover, for any one patient this absorption constant varies with time.
Given this, Doctor Tomás Rubio proposed using a technique based in blood extractions. He concluded that, by taking samples at two different times, the level of glycemia can be measured and the constants of absorption and elimination can be calculated. Knowing these constants, the exact amount of insulin needed by the patient can be calculated. Nevertheless, if the patient suffers another decompensation crisis, it will be necessary to recalculate these constants.
Apart from its use in emergency services, this model has applications for self-medication by the patient at home. For example, it can be used with the insulin perfusion pumps currently used to apply a quantity of insulin, depending on the glucose level. It can also be used with patients undergoing surgery in order to know how much insulin has to be administered during the operation and to control the amount of glucose administered via serum.
Two types of patients
Two types of patients are distinguished in this study. The first corresponds to insulin-dependant diabetic patients, normally young people, who require insulin for their treatment and whose acute condition is usually diabetic ketoacidosis. The second type corresponds to patients who have very high levels of glycemia, usually older and overweight people, who are normally regulated through orally administered antidiabetic medication, although many of these also end up needing insulin. These patients show acute conditions of hyperosmolar coma and symptomatic hyperglycemia.
The research was carried out on patients with the different acute conditions: diabetic ketoacidosis, hyperosmolar coma and symptomatic hyperglycemia. From the analysis of the results it was concluded that, for the construction of the mathematical model, the measuring of glycemia and insulin were necessary
Iñaki Casado Redin
Nafarroako Unibertsitate Publikoa
(+34) 948 16 97 82
Iñaki Casado Redin | BasqueResearch
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.
It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...