Personalised doses of insulin
Diabetes is a widespread illness affecting 5 per cent of the population. In diabetics the metabolism produces an excess of glucose in the blood and, as a result, a number of sufferers need doses of insulin which allows them to regulate their glucose levels.
Currently, the method of administering insulin to diabetic patients making use of emergency services for insulin dosage depends on the experience of the qualified personnel. That is, the same patient can receive different insulin doses, and in different ways, according to the doctor attending her or him.
In order to improve this system of administration, Doctor Tomás Rubio proposed in his doctoral thesis the development of a mathematical model which would facilitate predicting the exact amount of insulin needed by a patient at any time. The thesis showed that both the absorption constant (the time taken for the insulin to enter the blood and become effective) as well as the elimination constant (the time taken for the insulin to disappear), is different for each patient. Moreover, for any one patient this absorption constant varies with time.
Given this, Doctor Tomás Rubio proposed using a technique based in blood extractions. He concluded that, by taking samples at two different times, the level of glycemia can be measured and the constants of absorption and elimination can be calculated. Knowing these constants, the exact amount of insulin needed by the patient can be calculated. Nevertheless, if the patient suffers another decompensation crisis, it will be necessary to recalculate these constants.
Apart from its use in emergency services, this model has applications for self-medication by the patient at home. For example, it can be used with the insulin perfusion pumps currently used to apply a quantity of insulin, depending on the glucose level. It can also be used with patients undergoing surgery in order to know how much insulin has to be administered during the operation and to control the amount of glucose administered via serum.
Two types of patients
Two types of patients are distinguished in this study. The first corresponds to insulin-dependant diabetic patients, normally young people, who require insulin for their treatment and whose acute condition is usually diabetic ketoacidosis. The second type corresponds to patients who have very high levels of glycemia, usually older and overweight people, who are normally regulated through orally administered antidiabetic medication, although many of these also end up needing insulin. These patients show acute conditions of hyperosmolar coma and symptomatic hyperglycemia.
The research was carried out on patients with the different acute conditions: diabetic ketoacidosis, hyperosmolar coma and symptomatic hyperglycemia. From the analysis of the results it was concluded that, for the construction of the mathematical model, the measuring of glycemia and insulin were necessary
Iñaki Casado Redin
Nafarroako Unibertsitate Publikoa
(+34) 948 16 97 82
Iñaki Casado Redin | BasqueResearch
The most recent press releases about innovation >>>
Die letzten 5 Focus-News des innovations-reports im Überblick:
An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.
We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...
Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.
Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...
Nano-hologram paves way for integration of 3-D holography into everyday electronics
An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...
In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.
In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...
Biofilms: Researchers find the causes of water-repelling properties
Dental plaque and the viscous brown slime in drainpipes are two familiar examples of bacterial biofilms. Removing such bacterial depositions from surfaces is...