Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Personalised doses of insulin

05.02.2003


Diabetes is a widespread illness affecting 5 per cent of the population. In diabetics the metabolism produces an excess of glucose in the blood and, as a result, a number of sufferers need doses of insulin which allows them to regulate their glucose levels.



Currently, the method of administering insulin to diabetic patients making use of emergency services for insulin dosage depends on the experience of the qualified personnel. That is, the same patient can receive different insulin doses, and in different ways, according to the doctor attending her or him.

In order to improve this system of administration, Doctor Tomás Rubio proposed in his doctoral thesis the development of a mathematical model which would facilitate predicting the exact amount of insulin needed by a patient at any time. The thesis showed that both the absorption constant (the time taken for the insulin to enter the blood and become effective) as well as the elimination constant (the time taken for the insulin to disappear), is different for each patient. Moreover, for any one patient this absorption constant varies with time.


Given this, Doctor Tomás Rubio proposed using a technique based in blood extractions. He concluded that, by taking samples at two different times, the level of glycemia can be measured and the constants of absorption and elimination can be calculated. Knowing these constants, the exact amount of insulin needed by the patient can be calculated. Nevertheless, if the patient suffers another decompensation crisis, it will be necessary to recalculate these constants.

Apart from its use in emergency services, this model has applications for self-medication by the patient at home. For example, it can be used with the insulin perfusion pumps currently used to apply a quantity of insulin, depending on the glucose level. It can also be used with patients undergoing surgery in order to know how much insulin has to be administered during the operation and to control the amount of glucose administered via serum.

Two types of patients

Two types of patients are distinguished in this study. The first corresponds to insulin-dependant diabetic patients, normally young people, who require insulin for their treatment and whose acute condition is usually diabetic ketoacidosis. The second type corresponds to patients who have very high levels of glycemia, usually older and overweight people, who are normally regulated through orally administered antidiabetic medication, although many of these also end up needing insulin. These patients show acute conditions of hyperosmolar coma and symptomatic hyperglycemia.

The research was carried out on patients with the different acute conditions: diabetic ketoacidosis, hyperosmolar coma and symptomatic hyperglycemia. From the analysis of the results it was concluded that, for the construction of the mathematical model, the measuring of glycemia and insulin were necessary

Contact :
Iñaki Casado Redin
Nafarroako Unibertsitate Publikoa
inaki.casado@unavarra.es
(+34) 948 16 97 82

Iñaki Casado Redin | BasqueResearch
Further information:
http://www.unavarra.es

More articles from Health and Medicine:

nachricht Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania

nachricht The strange double life of Dab2
10.01.2017 | University of Miami Miller School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

Im Focus: Bacterial Pac Man molecule snaps at sugar

Many pathogens use certain sugar compounds from their host to help conceal themselves against the immune system. Scientists at the University of Bonn have now, in cooperation with researchers at the University of York in the United Kingdom, analyzed the dynamics of a bacterial molecule that is involved in this process. They demonstrate that the protein grabs onto the sugar molecule with a Pac Man-like chewing motion and holds it until it can be used. Their results could help design therapeutics that could make the protein poorer at grabbing and holding and hence compromise the pathogen in the host. The study has now been published in “Biophysical Journal”.

The cells of the mouth, nose and intestinal mucosa produce large quantities of a chemical called sialic acid. Many bacteria possess a special transport system...

Im Focus: Newly proposed reference datasets improve weather satellite data quality

UMD, NOAA collaboration demonstrates suitability of in-orbit datasets for weather satellite calibration

"Traffic and weather, together on the hour!" blasts your local radio station, while your smartphone knows the weather halfway across the world. A network of...

Im Focus: Repairing defects in fiber-reinforced plastics more efficiently

Fiber-reinforced plastics (FRP) are frequently used in the aeronautic and automobile industry. However, the repair of workpieces made of these composite materials is often less profitable than exchanging the part. In order to increase the lifetime of FRP parts and to make them more eco-efficient, the Laser Zentrum Hannover e.V. (LZH) and the Apodius GmbH want to combine a new measuring device for fiber layer orientation with an innovative laser-based repair process.

Defects in FRP pieces may be production or operation-related. Whether or not repair is cost-effective depends on the geometry of the defective area, the tools...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

Energy-Efficient Building Operation: Monitoring Platform MONDAS Identifies Energy-Saving Potential

16.01.2017 | Trade Fair News

Designing Architecture with Solar Building Envelopes

16.01.2017 | Architecture and Construction

Sensory Stimuli Control Dopamine in the Brain

13.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>