The use of combinations of antiretroviral drugs including nucleoside analogs, protease inhibitors (PIs) and reverse transcriptase inhibitors - collectively termed highly active anti-retroviral therapy (HAART) - has resulted in a dramatic improvement in health status for a large number of HIV-infected individuals.
Side effects in many users, however, cause non-adherence to treatment regimes and concern over their long-term use in the management of chronic HIV infection. The adverse effects of PIs include abnormalities in lipid metabolism, insulin resistance, and premature atherosclerosis. Whether the latter is caused directly by the drugs or as a consequence of lipid abnormalities and insulin resistance has not been clear- until now.
A report in the February 3 issue of the Journal of Clinical Investigation shows that HIV protease inhibitors directly promote atherosclerosis in mice. Led by Eric Smart, the researchers from the University of Kentucky Medical School in Lexington also examined the situation in human cells, and found that protease inhibitors induced changes in particular cells (called macrophages) that are like those seen in atherosclerotic lesions.
NIH scientists describe potential antibody treatment for multidrug-resistant K. pneumoniae
14.03.2018 | NIH/National Institute of Allergy and Infectious Diseases
Researchers identify key step in viral replication
13.03.2018 | University of Pittsburgh Schools of the Health Sciences
Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...
On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...
The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...
At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.
When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...
At the ILA Berlin, hall 4, booth 202, Fraunhofer FHR will present two radar sensors for navigation support of drones. The sensors are valuable components in the implementation of autonomous flying drones: they function as obstacle detectors to prevent collisions. Radar sensors also operate reliably in restricted visibility, e.g. in foggy or dusty conditions. Due to their ability to measure distances with high precision, the radar sensors can also be used as altimeters when other sources of information such as barometers or GPS are not available or cannot operate optimally.
Drones play an increasingly important role in the area of logistics and services. Well-known logistic companies place great hope in these compact, aerial...
16.03.2018 | Event News
13.03.2018 | Event News
08.03.2018 | Event News
16.03.2018 | Earth Sciences
16.03.2018 | Physics and Astronomy
16.03.2018 | Life Sciences