Vessel wall cells and blood cells have been found to release cell particles which can damage blood vessels. This was demonstrated in laboratory experiments carried out by Marja van Wijk during her doctoral research at the University of Amsterdam. Poorly functioning blood vessels play a role in pre-eclampsia.
For her research (conducted at the Academic Medical Centre, University of Amsterdam) Van Wijk isolated blood vessels from pieces of tissue taken from pregnant women. She placed the blood vessels in a solution of microparticles isolated from the blood of pregnant women with and without pre-eclampsia. A so-called wire myograph was then used to measure the functioning of the blood vessels.
Vessels in a solution of affected microparticles were found to function less well than vessels with healthy particles. Which microparticles or parts thereof are responsible for the vessel damage is not clear. Exactly how the particles are formed must also be investigated.
Michel Philippens | alfa
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