Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:


Researchers find a genetic connection in Sudden Infant Death Syndrome (SIDS)


Information could help identify at-risk individuals and estimate

Researchers at Rush-Presbyterian-St. Luke’s Medical Center have found evidence supporting a relationship between SIDS and the 5-HTT gene in both African-Americans and Caucasians. They found a significant positive association between SIDS and the L/L genotype, and between SIDS and the 5-HTT L allele, and a negative association between SIDS and the S/S genotype. This information might eventually lead to the identification of infants at risk for SIDS.

Sudden Infant Death Syndrome (SIDS) claims the lives of more than 2,500 American infants every year, and African American children are far more likely to fall victim than Caucasians. Previous research into a genetic connection has pointed to a possible relationship between SIDS and a gene (5-HTT) that regulates serotonin uptake.

Dr. Debra E. Weese-Mayer, professor of pediatrics at Rush-Presbyterian-St. Luke’s Medical Center, led the new study. The study will appear in an upcoming print issue of the American Journal of Medical Genetics and will be published online January 17 via Wiley InterScience.

This study of SIDS and the 5-HTT gene was motivated by previous observations of decreased serotonergic receptor binding in SIDS cases. The 5-HTT gene regulates membrane uptake of serotonin and was therefore considered a likely candidate for SIDS studies. Furthermore, a recent Japanese study of the 5-HTT gene found an association between SIDS and the L/L genotype and L allele.

Seeking a similar association in an American population, researchers collected DNA samples from 87 U.S. SIDS cases, some Caucasian and some African-American. They also collected DNA from two sets of control subjects. The first set was screened for family history of SIDS or other relevant conditions, then matched to the SIDS cases for ethnicity and gender. The second set of controls included 334 random DNA samples used to determine population genotype frequencies. For each DNA sample, the 5-HTTLPR polymorphism was genotyped.

The results suggest an association between SIDS and the 5-HTT gene. "There was a significant difference in genotype distribution and an increased frequency of the L allele in SIDS cases versus ethnicity/gender matched controls with no family history of SIDS or autonomic dysfunction," the authors report. "Furthermore, there were significantly fewer SIDS cases versus controls with no long allele (S/S genotype) in the entire cohort and within the Caucasian subgroup; and significantly more SIDS cases versus controls with no short allele (L/L genotype) in the entire cohort."

The researchers also found that genotype frequency distributions and allele frequency distributions for 5-HTT were significantly different when evaluated across all ethnic groups. Despite ethnic variations, however, SIDS cases were more likely than controls to have the long allele in the Japanese, Caucasian, and African American study samples.

The study’s results are compelling, though limited by the research design that included only confirmed anonymous SIDS cases from the NIH-supported University of Maryland Brain Bank, according to Dr. Weese-Mayer. Further studies should encompass larger numbers and more ethnicities and also include the 5-HTT intron 2 VTNR which influences gene expression. Likewise, Dr. Weese-Mayer et al pointed out that "recognizing the strong relationship between tobacco exposure (prenatal and postnatal) and SIDS risk, future studies of genetic polymorphisms must also include detailed smoking history to clarify the role of gene-environment interaction."

"If a larger data set reflects observations similar to those in this report," the authors conclude, "the serotonergic system will represent a key area for further investigation into the causal basis for SIDS, with the goal of identifying genetic risk factors that will aide in recognizing at-risk individuals who require specialized intervention strategies and in counseling families as to the risk of recurrence."

Article: "Sudden Infant Death Syndrome: Association with a Promoter Polymorphism of the Serotonin Transporter Gene." Debra E. Weese-Mayer, Elizabeth M. Berry-Kravis, Brion S. Maher, Jean M. Silvestri, Mark E. Curran, and Mary L. Marazita, American Journal of Medical Genetics, January 17, 2003. For more information visit

The Center for SIDS Research and Disorders of Respiratory Control in Infancy and Childhood at Rush Children’s Hospital of Rush-Presbyterian-St. Luke’s Medical Center is a resource for infants, children and their families. Center physicians are internationally recognized for their research contributions in respiratory physiology. The Center includes the Pediatric Respiratory Physiology Laboratory, equipped with state-of-the-art technology to provide a physiological assessment of respiration. For more information visit:

John M. Pontarelli | EurekAlert!
Further information:

More articles from Health and Medicine:

nachricht NIH scientists describe potential antibody treatment for multidrug-resistant K. pneumoniae
14.03.2018 | NIH/National Institute of Allergy and Infectious Diseases

nachricht Researchers identify key step in viral replication
13.03.2018 | University of Pittsburgh Schools of the Health Sciences

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Locomotion control with photopigments

Researchers from Göttingen University discover additional function of opsins

Animal photoreceptors capture light with photopigments. Researchers from the University of Göttingen have now discovered that these photopigments fulfill an...

Im Focus: Surveying the Arctic: Tracking down carbon particles

Researchers embark on aerial campaign over Northeast Greenland

On 15 March, the AWI research aeroplane Polar 5 will depart for Greenland. Concentrating on the furthest northeast region of the island, an international team...

Im Focus: Unique Insights into the Antarctic Ice Shelf System

Data collected on ocean-ice interactions in the little-researched regions of the far south

The world’s second-largest ice shelf was the destination for a Polarstern expedition that ended in Punta Arenas, Chile on 14th March 2018. Oceanographers from...

Im Focus: ILA 2018: Laser alternative to hexavalent chromium coating

At the 2018 ILA Berlin Air Show from April 25–29, the Fraunhofer Institute for Laser Technology ILT is showcasing extreme high-speed Laser Material Deposition (EHLA): A video documents how for metal components that are highly loaded, EHLA has already proved itself as an alternative to hard chrome plating, which is now allowed only under special conditions.

When the EU restricted the use of hexavalent chromium compounds to special applications requiring authorization, the move prompted a rethink in the surface...

Im Focus: Radar for navigation support from autonomous flying drones

At the ILA Berlin, hall 4, booth 202, Fraunhofer FHR will present two radar sensors for navigation support of drones. The sensors are valuable components in the implementation of autonomous flying drones: they function as obstacle detectors to prevent collisions. Radar sensors also operate reliably in restricted visibility, e.g. in foggy or dusty conditions. Due to their ability to measure distances with high precision, the radar sensors can also be used as altimeters when other sources of information such as barometers or GPS are not available or cannot operate optimally.

Drones play an increasingly important role in the area of logistics and services. Well-known logistic companies place great hope in these compact, aerial...

All Focus news of the innovation-report >>>



Industry & Economy
Event News

Ultrafast Wireless and Chip Design at the DATE Conference in Dresden

16.03.2018 | Event News

International Tinnitus Conference of the Tinnitus Research Initiative in Regensburg

13.03.2018 | Event News

International Virtual Reality Conference “IEEE VR 2018” comes to Reutlingen, Germany

08.03.2018 | Event News

Latest News

Wandering greenhouse gas

16.03.2018 | Earth Sciences

'Frequency combs' ID chemicals within the mid-infrared spectral region

16.03.2018 | Physics and Astronomy

Biologists unravel another mystery of what makes DNA go 'loopy'

16.03.2018 | Life Sciences

Science & Research
Overview of more VideoLinks >>>