Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers find a genetic connection in Sudden Infant Death Syndrome (SIDS)

20.01.2003


Information could help identify at-risk individuals and estimate

Researchers at Rush-Presbyterian-St. Luke’s Medical Center have found evidence supporting a relationship between SIDS and the 5-HTT gene in both African-Americans and Caucasians. They found a significant positive association between SIDS and the L/L genotype, and between SIDS and the 5-HTT L allele, and a negative association between SIDS and the S/S genotype. This information might eventually lead to the identification of infants at risk for SIDS.

Sudden Infant Death Syndrome (SIDS) claims the lives of more than 2,500 American infants every year, and African American children are far more likely to fall victim than Caucasians. Previous research into a genetic connection has pointed to a possible relationship between SIDS and a gene (5-HTT) that regulates serotonin uptake.



Dr. Debra E. Weese-Mayer, professor of pediatrics at Rush-Presbyterian-St. Luke’s Medical Center, led the new study. The study will appear in an upcoming print issue of the American Journal of Medical Genetics and will be published online January 17 via Wiley InterScience.

This study of SIDS and the 5-HTT gene was motivated by previous observations of decreased serotonergic receptor binding in SIDS cases. The 5-HTT gene regulates membrane uptake of serotonin and was therefore considered a likely candidate for SIDS studies. Furthermore, a recent Japanese study of the 5-HTT gene found an association between SIDS and the L/L genotype and L allele.

Seeking a similar association in an American population, researchers collected DNA samples from 87 U.S. SIDS cases, some Caucasian and some African-American. They also collected DNA from two sets of control subjects. The first set was screened for family history of SIDS or other relevant conditions, then matched to the SIDS cases for ethnicity and gender. The second set of controls included 334 random DNA samples used to determine population genotype frequencies. For each DNA sample, the 5-HTTLPR polymorphism was genotyped.

The results suggest an association between SIDS and the 5-HTT gene. "There was a significant difference in genotype distribution and an increased frequency of the L allele in SIDS cases versus ethnicity/gender matched controls with no family history of SIDS or autonomic dysfunction," the authors report. "Furthermore, there were significantly fewer SIDS cases versus controls with no long allele (S/S genotype) in the entire cohort and within the Caucasian subgroup; and significantly more SIDS cases versus controls with no short allele (L/L genotype) in the entire cohort."

The researchers also found that genotype frequency distributions and allele frequency distributions for 5-HTT were significantly different when evaluated across all ethnic groups. Despite ethnic variations, however, SIDS cases were more likely than controls to have the long allele in the Japanese, Caucasian, and African American study samples.

The study’s results are compelling, though limited by the research design that included only confirmed anonymous SIDS cases from the NIH-supported University of Maryland Brain Bank, according to Dr. Weese-Mayer. Further studies should encompass larger numbers and more ethnicities and also include the 5-HTT intron 2 VTNR which influences gene expression. Likewise, Dr. Weese-Mayer et al pointed out that "recognizing the strong relationship between tobacco exposure (prenatal and postnatal) and SIDS risk, future studies of genetic polymorphisms must also include detailed smoking history to clarify the role of gene-environment interaction."

"If a larger data set reflects observations similar to those in this report," the authors conclude, "the serotonergic system will represent a key area for further investigation into the causal basis for SIDS, with the goal of identifying genetic risk factors that will aide in recognizing at-risk individuals who require specialized intervention strategies and in counseling families as to the risk of recurrence."


###
Article: "Sudden Infant Death Syndrome: Association with a Promoter Polymorphism of the Serotonin Transporter Gene." Debra E. Weese-Mayer, Elizabeth M. Berry-Kravis, Brion S. Maher, Jean M. Silvestri, Mark E. Curran, and Mary L. Marazita, American Journal of Medical Genetics, January 17, 2003. For more information visit http://www.interscience.wiley.com/ajmg

The Center for SIDS Research and Disorders of Respiratory Control in Infancy and Childhood at Rush Children’s Hospital of Rush-Presbyterian-St. Luke’s Medical Center is a resource for infants, children and their families. Center physicians are internationally recognized for their research contributions in respiratory physiology. The Center includes the Pediatric Respiratory Physiology Laboratory, equipped with state-of-the-art technology to provide a physiological assessment of respiration. For more information visit: http://www.rush.edu/patients/children/services/specialties/respiratory


John M. Pontarelli | EurekAlert!
Further information:
http://www.rush.edu/

More articles from Health and Medicine:

nachricht Cystic fibrosis alters the structure of mucus in airways
29.06.2017 | University of Iowa Health Care

nachricht Mice provide insight into genetics of autism spectrum disorders
28.06.2017 | University of California - Davis

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making Waves

Computer scientists use wave packet theory to develop realistic, detailed water wave simulations in real time. Their results will be presented at this year’s SIGGRAPH conference.

Think about the last time you were at a lake, river, or the ocean. Remember the ripples of the water, the waves crashing against the rocks, the wake following...

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Nanostructures taste the rainbow

29.06.2017 | Physics and Astronomy

New technique unveils 'matrix' inside tissues and tumors

29.06.2017 | Life Sciences

Cystic fibrosis alters the structure of mucus in airways

29.06.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>