By using mouse models, the EU-funded DEPROHEALTH-project has demonstrated that some lactobacilli can have a beneficial effect on intestinal inflammation and infections. The major target disease in these mouse studies has been inflammation of the bowel. For this purpose, engineered lactobacilli were constructed. The modified strains that are most promising produce fair levels of an effective compound (an interleukine) that helps preventing the inflammation caused by bacteria. Four of the most promising candidate strains have been selected for future studies. These studies will test the effect of these strains in mice, in order to prepare future studies in humans.
Finding the effective bacteria has required a lot of background work. The research started with examining a number of wild strains of lactobacilli to find out about their potential capacity to interact with the host immune system. Ideally the beneficial bacteria should be taken orally, so their ability to survive passage trough the upper part of the intestinal tract is important and was indeed investigated. The acidic conditions in the stomach or the bile salts in the intestine may destroy their potential favourable influences.
DEPROHEALTH-project aims to design specific beneficial probiotic strains to avert intestinal illnesses. The project is developing new ways to tackle these illnesses by oral treatment which is much easier to administer than injections. Diseases targeted in the project are stomach ulcers linked with Helicobacter pylori, and infant diarrhoea, which is commonly caused by rotavirus. It also seeks to develop a new treatment against life long malign intestinal inflammation, such as Crohn’s disease, which severely affect the patient’s quality of life.
Dr. Annick Mercenier | Institut Pasteur de Lille
World first: Massive thrombosis removed during early pregnancy
20.07.2017 | Universitätsspital Bern
Therapy of preterm birth in sight?
19.07.2017 | Universitätsspital Bern
Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.
For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...
What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.
To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...
The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....
A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...
Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision
Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...
21.07.2017 | Event News
19.07.2017 | Event News
12.07.2017 | Event News
21.07.2017 | Earth Sciences
21.07.2017 | Power and Electrical Engineering
21.07.2017 | Physics and Astronomy