By using mouse models, the EU-funded DEPROHEALTH-project has demonstrated that some lactobacilli can have a beneficial effect on intestinal inflammation and infections. The major target disease in these mouse studies has been inflammation of the bowel. For this purpose, engineered lactobacilli were constructed. The modified strains that are most promising produce fair levels of an effective compound (an interleukine) that helps preventing the inflammation caused by bacteria. Four of the most promising candidate strains have been selected for future studies. These studies will test the effect of these strains in mice, in order to prepare future studies in humans.
Finding the effective bacteria has required a lot of background work. The research started with examining a number of wild strains of lactobacilli to find out about their potential capacity to interact with the host immune system. Ideally the beneficial bacteria should be taken orally, so their ability to survive passage trough the upper part of the intestinal tract is important and was indeed investigated. The acidic conditions in the stomach or the bile salts in the intestine may destroy their potential favourable influences.
DEPROHEALTH-project aims to design specific beneficial probiotic strains to avert intestinal illnesses. The project is developing new ways to tackle these illnesses by oral treatment which is much easier to administer than injections. Diseases targeted in the project are stomach ulcers linked with Helicobacter pylori, and infant diarrhoea, which is commonly caused by rotavirus. It also seeks to develop a new treatment against life long malign intestinal inflammation, such as Crohn’s disease, which severely affect the patient’s quality of life.
Dr. Annick Mercenier | Institut Pasteur de Lille
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Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.
The results will be published on March 22 in the journal „Astronomy & Astrophysics“.
Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...
Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.
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In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.
Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.
Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...
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