Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Saint Louis University researchers make breakthrough towards solving the cause of cancer development

17.01.2003


Results appear January 17 in the journal Molecular Cell



A lab headed by a Saint Louis University researcher has made a major breakthrough that could lead to a better molecular understanding of cancer.

Results published today in the Journal Molecular Cell by Ali Shilatifard, Ph.D., and colleagues show for the first time how a protein known to be involved in the development of cancer functions in normal cells.


The research shows how the protein "Bre1" plays a pivotal role in determining how the protein "Rad6" functions in modification of chromosomal DNA. Also participating in this research was the lab of Dr. Mark Johnston at Washington University School of Medicine.

Dr. Shilatifard, an associate professor of biochemistry and molecular biology at Saint Louis University School of Medicine, said this discovery should lead to several new promising areas of inquiry.

"This opens the door for further study of this protein in the regulation of gene expression," he said. "Once we understand the normal, we will have a better understanding of where something is going wrong."

This, in turn, could lead to ways to block the pathway and ultimately could stop cancer development, Dr. Shilatifard said.

"You can look at a cancer cell as a runaway freight train. There may be a thousand ways to stop it. You can derail it, take all the screws from its wheels or stop giving it fuel. This is one strategy for stopping it."

"Hopefully, together with other researchers, we can come up with a very strong way of stopping the train," he said.


Saint Louis University is a Jesuit, Catholic university ranked among the top research institutions in the nation. The University fosters the intellectual and character development of 11,000 students on campuses in St. Louis and Madrid, Spain. Founded in 1818, it is the oldest university west of the Mississippi and the second oldest Jesuit university in the United States. Through teaching, research, healthcare and community service, Saint Louis University is the place where knowledge touches lives. Learn more about SLU at www.slu.edu.

Matt Shaw | EurekAlert!
Further information:
http://www.slu.edu/

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

Im Focus: Using graphene to create quantum bits

In the race to produce a quantum computer, a number of projects are seeking a way to create quantum bits -- or qubits -- that are stable, meaning they are not much affected by changes in their environment. This normally needs highly nonlinear non-dissipative elements capable of functioning at very low temperatures.

In pursuit of this goal, researchers at EPFL's Laboratory of Photonics and Quantum Measurements LPQM (STI/SB), have investigated a nonlinear graphene-based...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

Physicists discover mechanism behind granular capillary effect

24.05.2017 | Physics and Astronomy

Measured for the first time: Direction of light waves changed by quantum effect

24.05.2017 | Physics and Astronomy

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>