Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Saint Louis University researchers make breakthrough towards solving the cause of cancer development

17.01.2003


Results appear January 17 in the journal Molecular Cell



A lab headed by a Saint Louis University researcher has made a major breakthrough that could lead to a better molecular understanding of cancer.

Results published today in the Journal Molecular Cell by Ali Shilatifard, Ph.D., and colleagues show for the first time how a protein known to be involved in the development of cancer functions in normal cells.


The research shows how the protein "Bre1" plays a pivotal role in determining how the protein "Rad6" functions in modification of chromosomal DNA. Also participating in this research was the lab of Dr. Mark Johnston at Washington University School of Medicine.

Dr. Shilatifard, an associate professor of biochemistry and molecular biology at Saint Louis University School of Medicine, said this discovery should lead to several new promising areas of inquiry.

"This opens the door for further study of this protein in the regulation of gene expression," he said. "Once we understand the normal, we will have a better understanding of where something is going wrong."

This, in turn, could lead to ways to block the pathway and ultimately could stop cancer development, Dr. Shilatifard said.

"You can look at a cancer cell as a runaway freight train. There may be a thousand ways to stop it. You can derail it, take all the screws from its wheels or stop giving it fuel. This is one strategy for stopping it."

"Hopefully, together with other researchers, we can come up with a very strong way of stopping the train," he said.


Saint Louis University is a Jesuit, Catholic university ranked among the top research institutions in the nation. The University fosters the intellectual and character development of 11,000 students on campuses in St. Louis and Madrid, Spain. Founded in 1818, it is the oldest university west of the Mississippi and the second oldest Jesuit university in the United States. Through teaching, research, healthcare and community service, Saint Louis University is the place where knowledge touches lives. Learn more about SLU at www.slu.edu.

Matt Shaw | EurekAlert!
Further information:
http://www.slu.edu/

More articles from Health and Medicine:

nachricht World first: Massive thrombosis removed during early pregnancy
20.07.2017 | Universitätsspital Bern

nachricht Therapy of preterm birth in sight?
19.07.2017 | Universitätsspital Bern

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Manipulating Electron Spins Without Loss of Information

Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.

For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...

Im Focus: The proton precisely weighted

What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.

To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...

Im Focus: On the way to a biological alternative

A bacterial enzyme enables reactions that open up alternatives to key industrial chemical processes

The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....

Im Focus: The 1 trillion tonne iceberg

Larsen C Ice Shelf rift finally breaks through

A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...

Im Focus: Laser-cooled ions contribute to better understanding of friction

Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision

Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Closing the Sustainability Circle: Protection of Food with Biobased Materials

21.07.2017 | Event News

»We are bringing Additive Manufacturing to SMEs«

19.07.2017 | Event News

The technology with a feel for feelings

12.07.2017 | Event News

 
Latest News

NASA looks to solar eclipse to help understand Earth's energy system

21.07.2017 | Earth Sciences

Stanford researchers develop a new type of soft, growing robot

21.07.2017 | Power and Electrical Engineering

Vortex photons from electrons in circular motion

21.07.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>