Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Saint Louis University researchers make breakthrough towards solving the cause of cancer development

17.01.2003


Results appear January 17 in the journal Molecular Cell



A lab headed by a Saint Louis University researcher has made a major breakthrough that could lead to a better molecular understanding of cancer.

Results published today in the Journal Molecular Cell by Ali Shilatifard, Ph.D., and colleagues show for the first time how a protein known to be involved in the development of cancer functions in normal cells.


The research shows how the protein "Bre1" plays a pivotal role in determining how the protein "Rad6" functions in modification of chromosomal DNA. Also participating in this research was the lab of Dr. Mark Johnston at Washington University School of Medicine.

Dr. Shilatifard, an associate professor of biochemistry and molecular biology at Saint Louis University School of Medicine, said this discovery should lead to several new promising areas of inquiry.

"This opens the door for further study of this protein in the regulation of gene expression," he said. "Once we understand the normal, we will have a better understanding of where something is going wrong."

This, in turn, could lead to ways to block the pathway and ultimately could stop cancer development, Dr. Shilatifard said.

"You can look at a cancer cell as a runaway freight train. There may be a thousand ways to stop it. You can derail it, take all the screws from its wheels or stop giving it fuel. This is one strategy for stopping it."

"Hopefully, together with other researchers, we can come up with a very strong way of stopping the train," he said.


Saint Louis University is a Jesuit, Catholic university ranked among the top research institutions in the nation. The University fosters the intellectual and character development of 11,000 students on campuses in St. Louis and Madrid, Spain. Founded in 1818, it is the oldest university west of the Mississippi and the second oldest Jesuit university in the United States. Through teaching, research, healthcare and community service, Saint Louis University is the place where knowledge touches lives. Learn more about SLU at www.slu.edu.

Matt Shaw | EurekAlert!
Further information:
http://www.slu.edu/

More articles from Health and Medicine:

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

nachricht Better equipped in the fight against lung cancer
16.05.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

Im Focus: Dozens of binaries from Milky Way's globular clusters could be detectable by LISA

Next-generation gravitational wave detector in space will complement LIGO on Earth

The historic first detection of gravitational waves from colliding black holes far outside our galaxy opened a new window to understanding the universe. A...

Im Focus: Entangled atoms shine in unison

A team led by Austrian experimental physicist Rainer Blatt has succeeded in characterizing the quantum entanglement of two spatially separated atoms by observing their light emission. This fundamental demonstration could lead to the development of highly sensitive optical gradiometers for the precise measurement of the gravitational field or the earth's magnetic field.

The age of quantum technology has long been heralded. Decades of research into the quantum world have led to the development of methods that make it possible...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

Unique scope of UV LED technologies and applications presented in Berlin: ICULTA-2018

12.04.2018 | Event News

 
Latest News

Space-like gravity weakens biochemical signals in muscle formation

23.05.2018 | Life Sciences

NIST puts the optical microscope under the microscope to achieve atomic accuracy

23.05.2018 | Physics and Astronomy

Magnesium magnificent for plasmonic applications

23.05.2018 | Materials Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>