Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Common cancer gene controls blood vessel growth

17.12.2002


Scientists from the Kimmel Cancer Center at Johns Hopkins and Northwestern University have found a new target to squeeze off a tumor’s blood supply. Research published in the December 17 issue of Cancer Cell shows how a common cancer-causing gene controls the switch for tumor blood vessel growth known as angiogenesis.



Recent evidence has shown that this gene, called Id1, is important for angiogenesis, a factor in cancer progression because it provides a needed blood source to tumor cells.

The new study concludes that the Id1 gene controls the angiogenesis pathway in certain cancers by turning off the production of a protein, thrombospondin-1 (TSP-1), a naturally occurring angiogenesis suppressor.


"We found activation of the Id1 gene, which is highly expressed in melanoma, breast, head and neck, brain, cervical, prostate, pancreatic and testicular cancers, results in decreased expression of TSP-1 and increased tumor blood vessel formation," says Rhoda M. Alani, M.D., assistant professor of oncology, dermatology, molecular biology and genetics in the Kimmel Cancer Center at Johns Hopkins and director of this study.

The researchers also found TSP-1 levels that were three- to fivefold greater in mice with Id1 gene function turned off than in mice with normal Id1.

To confirm their findings, the research team monitored blood vessel growth in mice with normal and crippled Id1 genes, then added a chemical that wiped out TSP-1. Control mice with normal Id1 showed well-developed blood vessels. Mice with a non-functioning Id1 gene showed little blood vessel growth when TSP-1 was activated. When the anti-TSP chemical was added to these mice, blood vessel growth resumed.

Efforts to find a way to use TSP-1 as an anti-cancer agent are under way in animal studies. "Because TSP-1 occurs naturally throughout the body, it can’t be used as a drug," says Roberto Pili, M.D., assistant professor of oncology in the Kimmel Cancer Center and co-author of the study. "But it could potentially be paired with another molecule and programmed to be released only in tumors." In addition to TSP-1, Alani and colleagues are studying Id1 targets important in other biologic processes, including signaling pathways inside cells.


This research was funded by the National Institutes of Health and the American Cancer Society.

Co-authors include Olga Volpert at the RH Lurie Cancer Center at Northwestern University, Hashmat Sikder at Johns Hopkins, Thomas Nelius and Tetiana Zaichuk from Northwestern, and Chad Morris, Clinton Shiflett, Meghann Devlin and Katherine Conant at Johns Hopkins.

Volpert, Olga V. et al, "Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1," Cancer Cell, Dec. 2002, Vol. 2.

Vanessa Wasta | EurekAlert!
Further information:
http://www.hopkinsmedicine.org

More articles from Health and Medicine:

nachricht NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures
17.11.2017 | National Institute of Standards and Technology (NIST)

nachricht High speed video recording precisely measures blood cell velocity
15.11.2017 | ITMO University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>