Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Common cancer gene controls blood vessel growth

17.12.2002


Scientists from the Kimmel Cancer Center at Johns Hopkins and Northwestern University have found a new target to squeeze off a tumor’s blood supply. Research published in the December 17 issue of Cancer Cell shows how a common cancer-causing gene controls the switch for tumor blood vessel growth known as angiogenesis.



Recent evidence has shown that this gene, called Id1, is important for angiogenesis, a factor in cancer progression because it provides a needed blood source to tumor cells.

The new study concludes that the Id1 gene controls the angiogenesis pathway in certain cancers by turning off the production of a protein, thrombospondin-1 (TSP-1), a naturally occurring angiogenesis suppressor.


"We found activation of the Id1 gene, which is highly expressed in melanoma, breast, head and neck, brain, cervical, prostate, pancreatic and testicular cancers, results in decreased expression of TSP-1 and increased tumor blood vessel formation," says Rhoda M. Alani, M.D., assistant professor of oncology, dermatology, molecular biology and genetics in the Kimmel Cancer Center at Johns Hopkins and director of this study.

The researchers also found TSP-1 levels that were three- to fivefold greater in mice with Id1 gene function turned off than in mice with normal Id1.

To confirm their findings, the research team monitored blood vessel growth in mice with normal and crippled Id1 genes, then added a chemical that wiped out TSP-1. Control mice with normal Id1 showed well-developed blood vessels. Mice with a non-functioning Id1 gene showed little blood vessel growth when TSP-1 was activated. When the anti-TSP chemical was added to these mice, blood vessel growth resumed.

Efforts to find a way to use TSP-1 as an anti-cancer agent are under way in animal studies. "Because TSP-1 occurs naturally throughout the body, it can’t be used as a drug," says Roberto Pili, M.D., assistant professor of oncology in the Kimmel Cancer Center and co-author of the study. "But it could potentially be paired with another molecule and programmed to be released only in tumors." In addition to TSP-1, Alani and colleagues are studying Id1 targets important in other biologic processes, including signaling pathways inside cells.


This research was funded by the National Institutes of Health and the American Cancer Society.

Co-authors include Olga Volpert at the RH Lurie Cancer Center at Northwestern University, Hashmat Sikder at Johns Hopkins, Thomas Nelius and Tetiana Zaichuk from Northwestern, and Chad Morris, Clinton Shiflett, Meghann Devlin and Katherine Conant at Johns Hopkins.

Volpert, Olga V. et al, "Id1 regulates angiogenesis through transcriptional repression of thrombospondin-1," Cancer Cell, Dec. 2002, Vol. 2.

Vanessa Wasta | EurekAlert!
Further information:
http://www.hopkinsmedicine.org

More articles from Health and Medicine:

nachricht Investigators may unlock mystery of how staph cells dodge the body's immune system
22.09.2017 | Cedars-Sinai Medical Center

nachricht Monitoring the heart's mitochondria to predict cardiac arrest?
21.09.2017 | Boston Children's Hospital

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The pyrenoid is a carbon-fixing liquid droplet

Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.

A warming planet

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Rainbow colors reveal cell history: Uncovering β-cell heterogeneity

22.09.2017 | Life Sciences

Penn first in world to treat patient with new radiation technology

22.09.2017 | Medical Engineering

Calculating quietness

22.09.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>