Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New 3-D mammography system may improve breast imaging

11.12.2002


Developed at MGH, digital tomosynthesis may better identify malignant lesions



A new approach to mammography, developed by researchers at Massachusetts General Hospital (MGH), holds the potential for greatly improving the detection of breast lesions and the ability to predict whether they are benign or malignant. In a presentation earlier this month at the scientific assembly of the Radiological Society of North America (RSNA), Elizabeth Rafferty, MD, of the MGH Breast Imaging Service described initial results of a study comparing the new technique, called digital tomosynthesis, to standard mammography. Among the new technique’s advantages, she explains, is a significant reduction in false positive test results.

"The overlap of breast structures presents a major challenge for radiologists, both because these tissues can hide cancers and because they produce shadows which mimic a lesion on conventional mammography," Rafferty says. "These false positive studies account for almost 25 percent of the instances when women are recalled for additional imaging from their screening mammograms. By eliminating this structure overlap, tomosynthesis prevents virtually all of these unnecessary callbacks, along with the anxiety they create."


Tomosynthesis differs from standard mammography in the way a CT scan differs from a standard X-ray procedure. In tomosynthesis, the X-ray tube moves in a 50-degree arc around the breast while 11 low-dose images are taken during a 7-second examination. A computer then assembles the information to provide high-resolution cross-section and three-dimensional images that can be reviewed by the radiologist at a computer workstation.

"Tomosynthesis takes digital mammography to the next level," adds Daniel Kopans, MD, MGH director of breast imaging and a coauthor of Rafferty’s presentation. "It is a modification of a standard digital mammography unit. The breast is held the same way, but women will be happy to learn that the test requires only one compression of each breast rather than the two currently required by standard mammography." Kopans is one of the inventors of the digital tomosynthesis system, which has been patented by the MGH.

Rafferty’s report covers data from the first 100 women to volunteer for tomosynthesis in addition to standard mammography at MGH. Her data indicates that tomosynthesis makes lesions easier for the radiologist to see and also makes visible some lesions not detectable by conventional procedures. The radiologists who reviewed both standard mammograms and tomosynthsis images for the study reported being significantly more confident in determining the malignancy of lesions with tomosynthesis, Rafferty said.

Richard Moore, head of MGH Breast Imaging Research, says, "We can now see the tree in the forest. Digital tomosynthesis opens up multiple new avenues of investigation into better ways to detect and diagnose breast cancer early." Moore and physicist Tao Wu, PhD, helped develop the tomosynthesis device and algorithms for analyzing data and producing images.

Kopans and his team worked closely with representatives of General Electric to produce a prototype digital tomosynthesis system under a grant from the U.S. Department of Defense, and he is optimistic that ongoing clinical trials at the MGH will soon lead to FDA approval. "Tomosynthesis is going to revolutionize the way we look for breast cancers," Kopans says. "We have only begun to realize the potential of this technology."


The Massachusetts General Hospital, established in 1811, is the original and largest teaching hospital of Harvard Medical School. The MGH conducts the largest hospital-based research program in the United States, with an annual research budget of almost $300 million and major research centers in AIDS, the neurosciences, cardiovascular research, cancer, cutaneous biology, transplantation biology and photomedicine. In 1994, the MGH joined with Brigham and Women’s Hospital to form Partners HealthCare System, an integrated health care delivery system comprising the two academic medical centers, specialty and community hospitals, a network of physician groups and nonacute and home health services.

Sue McGreevey | EurekAlert!
Further information:
http://www.mgh.harvard.edu/

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Strathclyde-led research develops world's highest gain high-power laser amplifier

The world's highest gain high power laser amplifier - by many orders of magnitude - has been developed in research led at the University of Strathclyde.

The researchers demonstrated the feasibility of using plasma to amplify short laser pulses of picojoule-level energy up to 100 millijoules, which is a 'gain'...

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

New insights into the ancestors of all complex life

29.05.2017 | Earth Sciences

New photocatalyst speeds up the conversion of carbon dioxide into chemical resources

29.05.2017 | Life Sciences

NASA's SDO sees partial eclipse in space

29.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>