Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New System Created by Rensselaer Researchers Speeds the Mapping of Blood Vessel Networks in Live Tumors

06.12.2002


Rensselaer researchers have developed an automated system, called RPI-Trace3D, that can swiftly map capillaries in a live tumor. What used to take days of manually tracing the vessels, now takes two minutes. The diagnostic tool, in use at Harvard Medical School and at Northeastern University, is a boon to oncologists who aim to understand how blood vessels form in tumors.



For the first time, medical scientists can quickly and precisely measure blood vessel properties to quantify the effects of various agents, such as new drugs, on capillary growth. Preventing new capillaries from forming in abnormal tissue by shutting off a tumor’s blood supply (angiogenesis) is a promising approach to fighting cancer.

The patent-pending RPI-Trace3D system was developed by a team led by Badri Roysam, director of the Center for Subsurface Sensing and Imaging Systems (CenSISS) at Rensselaer.


Sophisticated microscopes connected to computers can now generate complex 3-D images to allow scientists to peer deeper inside live tumors. Until recently, such intricate images took days to quantify because scientists had to manually trace the vessels. Typically, the results were less than perfect. The RPI-Trace3D system incorporated into the electronic microscopes identifies and traces all the capillaries of a living tumor in less than two minutes.

The system will significantly improve the search for better cancer-fighting drugs, says Harvard Medical School’s Edward Brown, a researcher in the school’s Department of Radiation Oncology. Brown is using the mapping system in collaboration with Northeastern University and other schools.

"The Rensselaer research team has generated truly impressive algorithms that trace out all the vessels in a 3-D network, as well as identify a number of properties of the vessels. This allows us to quantify these vessels accurately for the first time," Brown says.

Rensselaer graduate student Muhammad-Amri Abdul-Karim and Rensselaer graduate Khalid Al-Kofahi are key members of the Rensselaer team.

"We are the only cancer research team in the world that uses a rapid, fully automated,
tracing algorithm to quickly obtain measurements from 3-D blood vessel images," Abdul-Karim says.

Rensselaer Polytechnic Institute, founded in 1824, is the nation’s oldest technological university. The school offers degrees in engineering, the sciences, information technology, architecture, management, and the humanities and social sciences. Institute programs serve undergraduates, graduate students, and working professionals around the world. Rensselaer faculty are known for pre-eminence in research conducted in a wide range of research centers that are characterized by strong industry partnerships. The Institute is especially well known for its success in the transfer of technology from the laboratory to the marketplace so that new discoveries and inventions benefit human life, protect the environment, and strengthen economic development.

CONTACT: Badri Roysam (518) 276-8067, roysam@ecse.rpi.edu

Jodi Ackerman | EurekAlert!
Further information:
http://www.rpi.edu/dept/NewsComm/
http://www.rpi.edu/web/News/press_releases/2002/tumors.html

More articles from Health and Medicine:

nachricht NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures
17.11.2017 | National Institute of Standards and Technology (NIST)

nachricht High speed video recording precisely measures blood cell velocity
15.11.2017 | ITMO University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

Im Focus: Researchers Develop Data Bus for Quantum Computer

The quantum world is fragile; error correction codes are needed to protect the information stored in a quantum object from the deteriorating effects of noise. Quantum physicists in Innsbruck have developed a protocol to pass quantum information between differently encoded building blocks of a future quantum computer, such as processors and memories. Scientists may use this protocol in the future to build a data bus for quantum computers. The researchers have published their work in the journal Nature Communications.

Future quantum computers will be able to solve problems where conventional computers fail today. We are still far away from any large-scale implementation,...

Im Focus: Wrinkles give heat a jolt in pillared graphene

Rice University researchers test 3-D carbon nanostructures' thermal transport abilities

Pillared graphene would transfer heat better if the theoretical material had a few asymmetric junctions that caused wrinkles, according to Rice University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

NASA detects solar flare pulses at Sun and Earth

17.11.2017 | Physics and Astronomy

NIST scientists discover how to switch liver cancer cell growth from 2-D to 3-D structures

17.11.2017 | Health and Medicine

The importance of biodiversity in forests could increase due to climate change

17.11.2017 | Studies and Analyses

VideoLinks
B2B-VideoLinks
More VideoLinks >>>