Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Signaling pathway in melanoma could provide target for diagnosis, prevention and treatment

05.12.2002


Scientists at Emory University School of Medicine have identified a signaling pathway that is turned on when benign moles turn into early-stage malignant melanoma. The pathway could provide a new target for the diagnosis, prevention and treatment of the most lethal form of skin cancer. The research was reported in the December issue of the journal Clinical Cancer Research.



A team of Emory scientists led by Jack L. Arbiser, MD, PhD, found that the signaling pathway called mitogen activated protein kinase (MAP kinase) is abnormally turned on in melanoma, particularly in its early stages. The investigators studied levels of activated MAP kinase in 131 tissue samples from precancerous moles (atypical nevi) and malignant melanomas. They found high levels of activated MAP kinase in early melanomas, but not in moles that are the precursors to melanoma.

In addition to MAP kinase activation, the Emory investigators studied two genes known to be up-regulated by the MAP kinase –– vascular endothelial growth factor (VEGF) and tissue factor (TF). These genes also are known to be powerful stimulators of angiogenesis, which is the growth of microscopic blood vessels that nourishes cancerous tumors and leads to unregulated cell growth. The development of dormant tumors into actively proliferating tumors requires angiogenesis.


Dr. Arbiser and his colleagues did not find evidence of VEGF and TF in precancerous moles, but they did find these two target genes present in early melanomas.

According to the American Cancer Society, patients who have melanoma that has not spread below the skin have a survival rate of 96 percent beyond five years. But as the tumor begins to grow, the survival rate falls to 61 percent if the disease has reached the lymph nodes below the skin and 12 percent if it has spread to other organs in the body. Melanoma is the sixth most common form of cancer in U.S. men and the seventh most common form in U.S. women. The Cancer Society estimates that 53,600 new cases of melanoma will be diagnosed in the U.S. in 2002 and that 7,400 people will die from it.

"Our finding is of interest for two reasons," Dr. Arbiser says. "First, it may help physicians determine whether a mole is malignant, which is often difficult. Second, drugs that target MAP kinase could become available as creams and help prevent the change of moles to melanomas. Our study identifies MAP kinase as a pathway that must be targeted in the prevention and treatment of melanoma."

Holly Korschun | EurekAlert!
Further information:
http://www.emory.edu/

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>