Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Hopkins study finds combined PET-CT better at detecting ovarian cancer

04.12.2002


Hopkins radiologists have found that a combination of positron emission tomography (PET) and computed tomography (CT) detects cancer spread better than PET alone. In a study to be presented at the Radiological Society of North America (Abstract #1458, 10:57 AM, Thursday, December 5, Room S502AB), researchers reported that overall, PET-CT improves the ability to distinguish cancerous from normal tissue and locate metastases, where they have spread. The study used a scanner that fuses CT technology, which provides anatomical detail, with PET images, which detects metabolic activity of tumors.



Ten PET and 33 PET-CT scans were performed on 28 patients with ovarian cancer suspected to have spread to the abdominal cavity. There were three true positive and two true negative results with PET alone and 14 true positives and 10 true negatives with PET-CT. The PET scan alone produced two false positives, while PET-CT produced none. There were no false negatives with PET alone, and PET-CT had five. Combined PET-CT had a fairly high sensitivity rate, accurately diagnosing cancer 73.6 percent of the time (14 of 19), and PET alone was able to diagnose all three positive cancers.

"PET-CT was very specific, as it was able to distinguish cancer from non-cancer 100 percent of the time (10 of 10), while PET alone was specific for cancer only 50 percent of the time (two of four)," says Richard L. Wahl, M.D., the Henry N. Wagner Jr. professor of nuclear medicine and director of the division of nuclear medicine at Johns Hopkins. Routine contrast-enhanced CT was able to find disease in three of the five false negatives produced by PET-CT.


"The CT portion of combined PET-CT scanners is very helpful at locating disease, but it could miss some lesions that can be found with contrast-enhanced CT," says Elliot K. Fishman, M.D., professor of radiology and oncology and director of diagnostic imaging and body CT for the Kimmel Cancer Center at Johns Hopkins.

The researchers caution that this study is in a limited number of patients and additional research is necessary to determine the value of combined PET/CT over PET alone and over CT. "Nonetheless, our results are very promising and PET/CT is being used more often for patients with suspected recurrent ovarian cancer," says Wahl.

A second study by Wahl and Fishman being presented at the meeting (Abstract #740) shows how whole body CT provides a 19 percent improvement to combined PET-CT in detecting colorectal cancer recurrence.

Johns Hopkins was the first U.S. hospital to install a commercial combination PET-CT scanner for use with patients in a clinical setting. In addition to ovarian and colon cancer, the scanner is being used to detect a variety of cancers including breast, melanoma, and lung cancer.

In addition to Wahl and Fishman, other participants in this research were first author, Harpreet Pannu, M.D., Christian Cohade, M.D., Robert Bristow, M.D., and Fredrick Montz, M.D.

Vanessa Wasta | EurekAlert!
Further information:
http://www.hopkinsmedicine.org

More articles from Health and Medicine:

nachricht On track to heal leukaemia
18.01.2017 | Universitätsspital Bern

nachricht Penn vet research identifies new target for taming Ebola
12.01.2017 | University of Pennsylvania

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: How gut bacteria can make us ill

HZI researchers decipher infection mechanisms of Yersinia and immune responses of the host

Yersiniae cause severe intestinal infections. Studies using Yersinia pseudotuberculosis as a model organism aim to elucidate the infection mechanisms of these...

Im Focus: Interfacial Superconductivity: Magnetic and superconducting order revealed simultaneously

Researchers from the University of Hamburg in Germany, in collaboration with colleagues from the University of Aarhus in Denmark, have synthesized a new superconducting material by growing a few layers of an antiferromagnetic transition-metal chalcogenide on a bismuth-based topological insulator, both being non-superconducting materials.

While superconductivity and magnetism are generally believed to be mutually exclusive, surprisingly, in this new material, superconducting correlations...

Im Focus: Studying fundamental particles in materials

Laser-driving of semimetals allows creating novel quasiparticle states within condensed matter systems and switching between different states on ultrafast time scales

Studying properties of fundamental particles in condensed matter systems is a promising approach to quantum field theory. Quasiparticles offer the opportunity...

Im Focus: Designing Architecture with Solar Building Envelopes

Among the general public, solar thermal energy is currently associated with dark blue, rectangular collectors on building roofs. Technologies are needed for aesthetically high quality architecture which offer the architect more room for manoeuvre when it comes to low- and plus-energy buildings. With the “ArKol” project, researchers at Fraunhofer ISE together with partners are currently developing two façade collectors for solar thermal energy generation, which permit a high degree of design flexibility: a strip collector for opaque façade sections and a solar thermal blind for transparent sections. The current state of the two developments will be presented at the BAU 2017 trade fair.

As part of the “ArKol – development of architecturally highly integrated façade collectors with heat pipes” project, Fraunhofer ISE together with its partners...

Im Focus: How to inflate a hardened concrete shell with a weight of 80 t

At TU Wien, an alternative for resource intensive formwork for the construction of concrete domes was developed. It is now used in a test dome for the Austrian Federal Railways Infrastructure (ÖBB Infrastruktur).

Concrete shells are efficient structures, but not very resource efficient. The formwork for the construction of concrete domes alone requires a high amount of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

12V, 48V, high-voltage – trends in E/E automotive architecture

10.01.2017 | Event News

2nd Conference on Non-Textual Information on 10 and 11 May 2017 in Hannover

09.01.2017 | Event News

Nothing will happen without batteries making it happen!

05.01.2017 | Event News

 
Latest News

A big nano boost for solar cells

18.01.2017 | Power and Electrical Engineering

Glass's off-kilter harmonies

18.01.2017 | Materials Sciences

Toward a 'smart' patch that automatically delivers insulin when needed

18.01.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>