Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Diabetic gene linked to heart disease

04.12.2002


Heart disease is the most frequent, costly and severe complication of diabetes, affecting more than 70 percent of diabetic patients. There are geographic and ethnic differences in the risk of diabetic heart disease that cannot be fully explained by differences in conventional heart disease risk factors. Using a simple blood test, researchers at the Technion-Israel Institute of Technology have identified a gene that determines which diabetes patients are at greater risk for developing heart disease. Unlike other recent breakthroughs, such as the test for C-reactive protein, the test for this gene needs to be administered only once in a patient’s lifetime.



There are two forms of this predictive gene and they are present in approximately equal frequencies in the general population and in diabetics. Diabetics with one type of the gene have a five-fold greater risk of developing heart disease than those with the other form of the gene.

"If we can accurately determine which people with diabetes are at greatest risk for heart disease with a genetic test, there is no telling how many lives we could save with early intervention techniques," said Dr. Andrew P. Levy of the Technion Faculty of Medicine, who headed the research which was published in the December 4th issue of The Journal of the American College of Cardiology.


Dr. Eugene Braunwald, Professor of Medicine at Harvard Medical School and Chief Academic Officer at Partners HealthCare System agreed. "The demonstration in this paper that a straightforward determination of haptoglobin phenotypes can identify patients with diabetes with increased likelihood of cardiovascular disease should allow early and intensive preventive measures in such patients," he said.

Dr. Levy and his colleagues examined the genetic makeup of individuals in a sample from the Strong Heart Study, a population-based longitudinal study of heart disease in Native Americans, a group previously thought to be resistant to developing heart disease but are now suffering from the disease in large numbers. The relative genetic homogeneity of this population, along with the high prevalence of diabetes~ makes it an ideal group to study.

The sample group included 206 individuals with heart disease and 206 control cases aged 45-74. Using stored blood samples, the researchers looked at haptoglobin, a blood protein found in three different forms: 2-2, 1-1 and 2-1. Individuals with the 2-2 form were five times more likely to have heart disease than those with the 1-1 form. An intermediate risk was associated with those with the 2-1 form.

"This is an entirely novel and new idea that will certainly attract attention from many clinical investigators and scientists worldwide," said Dr. Myron L. Weisfeldt, Director, Department of Medicine at The Johns Hopkins Medical Institutions.

The ability of this genetic test to predict the risk of heart disease in diabetic patients regardless of ethnicity is strengthened by recently reported findings by Dr. Levy and colleagues from Germany. In that study, presented at the American Heart Association meetings in Chicago on November 19th, 935 patients with diabetes were followed after angioplasty. Individuals with the benign form of the gene were dramatically protected from suffering a heart attack or needing repeat angioplasty.

The current study also builds on previous work by Dr. Levy which reported on the association of the haptoglobin gene and other complications of diabetes such as kidney and eye damage. Articles detailing these findings were published in the New England Journal of Medicine and the Journal of the American Medical Association in September 2000. HaptoGuard, Inc., a company utilizing the technology developed by Dr. Levy’s research, hopes to build on these findings to improve management of the disease.


The Technion-Israel Institute of Technology is Israel’s leading scientific and technological center for applied research and education. It commands a worldwide reputation for its pioneering work in computer science, biotechnology, water-resource management, materials engineering, aerospace and medicine. The majority of the founders and managers of Israel’s high-tech companies are alumni.

Based in New York City, the American Technion Society is the leading American organization supporting higher education in Israel, with more than 20,000 supporters and 17 offices around the country.

American Society for Technion-Israel Institute of Technology
810 Seventh Avenue, New York, N.Y. 10019
(212) 262-6200, Fax: (212) 262-6155


Efrem Epstein | EurekAlert!
Further information:
http://www.ats.org
http://www.technion.ac.il/

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>