Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Miniature implantable sensor likely lifesaver for patients

25.11.2002


Using a tiny wireless sensor developed at Oak Ridge National Laboratory, doctors will know in minutes instead of hours if an organ is getting adequate blood flow after transplant or reconstructive surgery.



Conventional methods for assessing circulation involve invasive procedures or extensive laboratory testing. In some cases, by the time doctors realize there isn’t adequate blood flow to an organ or tissue, irreversible damage already has occurred.

"Our goal is to offer a technique that provides the physician with a very early indication of whether the surgery is successful," said Nance Ericson, who leads the effort from ORNL’s Engineering Science and Technology Division. Ericson is working with Mark Wilson, a surgeon at the University of Pittsburgh, and Gerard Coté of Texas A&M University.


The tiny implantable sensor – about the diameter of a quarter -- and micro-instrumentation being developed by Ericson would provide real-time information by transmitting data to a nearby receiver. Specifically, the unit employs optical sensors to assess tissue circulation. Preliminary tests using laboratory rats have provided encouraging results.

"Although we have more work to do, we are extremely optimistic that this technology will dramatically improve the ability of physicians to care for critically ill patients," Wilson said.

While Wilson provides the practicing medical component required in this research, Coté, who heads the optical biosensing laboratory within the Department of Biomedical Engineering at Texas A&M, provides expertise in modeling, post-processing and sensor optimization. Ericson and ORNL colleagues bring to the team vast knowledge in engineering, signal processing, system design, radio frequency telemetry design, and fabrication and micro-fabrication techniques.

Over the next year, Ericson will be working to miniaturize the sensors and associated electronics, which will enable surgeons to implant the sensor in the precise area of interest, either as a subdermal or deep-tissue implant. Ericson envisions the sensor remaining in the body, which would avoid additional surgery; however, that is an area that may require additional evaluation. Other efforts include biosensor optimization, design of low-power highly miniaturized signal processing and telemetry electronics, and development of encapsulation techniques.

Once they have made sufficient progress in these areas, the research team plans to conduct additional testing of the sensing techniques to demonstrate clinical significance. Finally, the procedure would be subject to clinical trials and Food and Drug Administration approval.

Assuming the technology passes all the tests, Ericson envisions this work leading to significant benefits.

"This research is based on several key developments in optics and micro-fabrication that have far-reaching implications for future directions in a multitude of clinically significant biomedical sensing systems," Ericson said. "Through these innovations, biomedical microsensors are poised to make major technology advances to help meet the critical needs of patients in hospitals, emergency care facilities and extended-care facilities."

The ability to prevent -- or at least detect -- circulation problems quickly could lead not only to fewer complications during surgery, but also could reduce the number of deaths attributable to those complications.

Although not a part of this project, Ericson sees this leading to several other photonics-based microsensors for making measurements in a number of areas. For example, this approach could be useful for measuring arterial blood gases, which are primary indicators of respiratory function, or serum lactate, which is a marker for the severity of tissue injury. Current methods require obtaining blood samples and then sending those samples to a lab for analysis.


Funding for this research is provided by DOE’s Office of Science. Initial funding began in 1997 through ORNL’s Laboratory Directed Research and Development program, also funded by DOE.

ORNL is a DOE multiprogram research facility managed by UT-Battelle.

Ron Walli | EurekAlert!
Further information:
http://www.ornl.gov/news

More articles from Health and Medicine:

nachricht Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University

nachricht The first analysis of Ewing's sarcoma methyloma opens doors to new treatments
01.12.2016 | IDIBELL-Bellvitge Biomedical Research Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>