Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Beating pneumonia by a nose

06.11.2002


Electronic nose detects pneumonia in critically ill patients



According to a team of researchers from University of Pennsylvania School of Medicine, an electronic nose - a relatively new version of a sensor previously used in the food, wine and perfume industries - can quickly and accurately diagnose pneumonia in critically ill, mechanically ventilated patients. The results will be presented at the CHEST 2002 Annual Meeting Tuesday, November 5th in San Diago.

"We wanted to further explore using the e-nose after the exciting results of an initial study we conducted back in 1997 with only 20 patients," said C. William Hanson, III, MD, associate professor of Anesthesia, Surgery and Internal Medicine, and lead author of the study. When it comes to lower pulmonary infections, especially in critically ill patients, time is of the essence for disease control. "Rather than waiting two to three days for the results of a bacterial culture or relying on chest X-rays which aren’t always accurate, the e-nose can give us a head start toward a proper diagnoses. We could avoid over-prescribing powerful antibiotics which are usually given to patients while we’re waiting for their test results, even though we don’t know if they actually need them," adds Hanson.


In the current study, 415 mechanically ventilated, critical care patients were screened for the presence of ventilator associated pneumonia (VAP) using a clinical pneumonia score (CPIS). Patients with high CPIS scores were enrolled in the study as well as control patients who had no evidence of pneumonia. An exhaled breath sample was taken from each patient directly from the expiratory limb of the ventilator circuit into an electronic nose made by Cyrano Sciences, Pasadena, CA. This differs from the original study where breath samples were collected in plastic bags from the ventilators of intubated intensive care patients and then fed into a different electronic nose.

The e-nose contains an array of sensors consisting of carbon-black/polymer composites. The patient’s exhaled breath gas was passed over these sensors which interact with volatile molecules to produce unique patterns that are displayed in two-dimensional "maps," or dot patterns on a computer screen. The results were analyzed using pattern recognition algorithms and assessed for a correlation between the actual CPIS scores and the one predicted by the nose. Hanson and his colleagues found that the nose made clear distinctions between the patients who were infected and those who were not.

"The data show good correlation between the actual scores and those predicted by the data from the e-nose sensor," said Hanson. "Furthermore, this study suggests that the commercial electronic nose, as is, would be reasonably successful in predicting ventilator associated pneumonia. It would be even more suited to the task if the sensor array could be customized." Preliminary data also suggests that the e-nose may be able to distinguish between pneumonias caused by different bacterial infections. Cyrano Sciences, Inc., donated a "Cyranose" electronic nose for use in this study.


###
Editor’s Note: Dr. Hanson does not have any financial ties with Cyrano Sciences, Inc., and will be available at the CHEST 2002 Annual Meeting and by phone for comment.

Olivia Fermano | EurekAlert!
Further information:
http://www.med.upenn.edu/

More articles from Health and Medicine:

nachricht Norovirus evades immune system by hiding out in rare gut cells
12.10.2017 | University of Pennsylvania School of Medicine

nachricht Flexible sensors can detect movement in GI tract
11.10.2017 | Massachusetts Institute of Technology

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Smart sensors for efficient processes

Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).

When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...

Im Focus: Cold molecules on collision course

Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.

How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...

Im Focus: Shrinking the proton again!

Scientists from the Max Planck Institute of Quantum Optics, using high precision laser spectroscopy of atomic hydrogen, confirm the surprisingly small value of the proton radius determined from muonic hydrogen.

It was one of the breakthroughs of the year 2010: Laser spectroscopy of muonic hydrogen resulted in a value for the proton charge radius that was significantly...

Im Focus: New nanomaterial can extract hydrogen fuel from seawater

Hybrid material converts more sunlight and can weather seawater's harsh conditions

It's possible to produce hydrogen to power fuel cells by extracting the gas from seawater, but the electricity required to do it makes the process costly. UCF...

Im Focus: Small collisions make big impact on Mercury's thin atmosphere

Mercury, our smallest planetary neighbor, has very little to call an atmosphere, but it does have a strange weather pattern: morning micro-meteor showers.

Recent modeling along with previously published results from NASA's MESSENGER spacecraft -- short for Mercury Surface, Space Environment, Geochemistry and...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

World Health Summit 2017: International experts set the course for the future of Global Health

10.10.2017 | Event News

Climate Engineering Conference 2017 Opens in Berlin

10.10.2017 | Event News

Conference Week RRR2017 on Renewable Resources from Wet and Rewetted Peatlands

28.09.2017 | Event News

 
Latest News

A single photon reveals quantum entanglement of 16 million atoms

16.10.2017 | Physics and Astronomy

The melting ice makes the sea around Greenland less saline

16.10.2017 | Earth Sciences

On the generation of solar spicules and Alfvenic waves

16.10.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>