Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Research Will Push Forward Fight Against Leukaemia

25.10.2002


A project which aims to make laboratory-grown leukaemia cells change form and then be used to prime a patient’s own immune system to kill off malignant cells has begun in Edinburgh. If successful, the study could give clinicians a way of destroying residual leukaemic cells which are undetectable by microscope. The findings could be helpful in the treatment of acute myeloblastic leukaemia (AML), one of the most common forms of leukaemia in adults.



Although about 70% of patients with AML achieve complete remission of the disease after chemotherapy treatment, around half of the younger patients and the majority of elderly patients will ultimately relapse and die as a consequence of the disease. Three years survival rates are about 40% in younger patients and 10% in older patients.

This study, based at the John Hughes Bennett Laboratories at the University of Edinburgh, is led by haematologist Dr Marc Turner, who is Clinical Director of the Edinburgh and SE Scotland Blood Transfusion Centre.Dr Turner explained: “Relapse after initial successful chemotherapy is caused by residual leukaemic cells which are below a level which can be detected by microscope. Sometimes, they can cause the disease to restart, and it is much harder to treat the second time around. Methods of eliminating this minimal residual disease, such as bone marrow transplantation, can be successful but this form of treatment is only suitable for younger patients who are able to withstand the side effects of the treatment.”


“However, research work during the past few years has shown that it is possible to grow leukaemic cells in the laboratory and force them to change into a kind of immune cell called the dendritic cell. Dendritic cells are responsible for generating primary immune responses which can lead to the destruction of leukaemia cells.”

The work has now moved forward to the next phase of clinical trials, where patients with AML will donate bone marrow or blood cells before undergoing chemotherapy treatment. If they go into remission, their stored leukaemic cells will be specially cultured and changed into dendritic cells, which will be given back to the patient by injection. The dozen patients in the study will be carefully monitored for clinical and immunological responses. The trial will last for 12 to 18 months and is funded by the Leukaemia Research Fund and the Scottish National Blood Transfusion Service.

Dr David Grant, Scientific Director of the Leukaemia Research Fund, said: "The study of immunology - harnessing the body`s immune system to fight leukaemia - has advanced amazingly over the last 20 years. It is now crucial that we translate this knowledge into benefits for patients."

Linda Menzies | alfa
Further information:
http://www.ed.ac.uk

More articles from Health and Medicine:

nachricht Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University

nachricht The first analysis of Ewing's sarcoma methyloma opens doors to new treatments
01.12.2016 | IDIBELL-Bellvitge Biomedical Research Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>