Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Hope for patients with advanced bowel cancer

21.10.2002


Early results of North American trials of chemotherapy drug oxaliplatin



For patients with bowel cancer that has spread to other organs despite treatment there has been little hope until now. However, early results of trials in North America of a chemotherapy drug called oxaliplatin, given in conjunction with two standard drugs, 5-FU and leucovorin, delay tumour progression by 70% compared with the control component of the study. There is also a significant improvement in the symptoms these patients experience.

Dr Mace Rothenberg from the Vanderbilt-Ingram Cancer Centre, Nashville, USA, lead a multi-centre trial in the USA involving 821 patients with advanced bowel – or colorectal - cancer to compare three different treatment strategies: 5-FU and leucovorin, oxaliplatin alone, or a combination of the drugs.


The delay in the progression and the shrinkage of the tumour lasted for a minimum of four weeks. "Both the delay in time to tumour progression and the reduction in tumour-related symptoms are very encouraging," said Dr Rothenberg, speaking at the European Society of Medical Oncology Congress in Nice, France, today (21 October 2002). "We found that patients suffered less from pain, weight loss and fatigue with the combination therapy."

The interim data from 463 patients were so promising that the US Food and Drug Administration gave its approval in August this year for oxaliplatin to be given to patients with advanced colorectal cancer that had progressed following first-line treatment. In Europe, however, oxaliplatin has been available since 1996. The drug is manufactured by Sanofi-Synthelabo in France.

Oxaliplatin can cause nausea, diarrhoea, anaemia and increased risk of infection, but on balance, the benefits appear to outweigh the side effects. 5-FU is given by intravenous drip and research is underway to find other easier means of delivery.

Bowel cancer affects nearly 150,000 people in the USA and around 35,000 people in the UK each year. It can arise in any part of the colon or rectum and is a leading cause of death.

"This trial should be fully mature in about six months. At that point we will know more about the impact of the oxaliplatin, 5-FU and leucovorin combination on the survival of patients with recurrent colorectal cancer," said Dr Rothenberg.

Gracemarie Bricalli | EurekAlert!

More articles from Health and Medicine:

nachricht Custom-tailored strategy against glioblastomas
26.09.2016 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New leukemia treatment offers hope
23.09.2016 | King Abdullah University of Science and Technology

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: OLED microdisplays in data glasses for improved human-machine interaction

The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.

“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...

Im Focus: Artificial Intelligence Helps in the Discovery of New Materials

With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.

Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...

Im Focus: Complex hardmetal tools out of the 3D printer

For the first time, Fraunhofer IKTS shows additively manufactured hardmetal tools at WorldPM 2016 in Hamburg. Mechanical, chemical as well as a high heat resistance and extreme hardness are required from tools that are used in mechanical and automotive engineering or in plastics and building materials industry. Researchers at the Fraunhofer Institute for Ceramic Technologies and Systems IKTS in Dresden managed the production of complex hardmetal tools via 3D printing in a quality that are in no way inferior to conventionally produced high-performance tools.

Fraunhofer IKTS counts decades of proven expertise in the development of hardmetals. To date, reliable cutting, drilling, pressing and stamping tools made of...

Im Focus: Launch of New Industry Working Group for Process Control in Laser Material Processing

At AKL’16, the International Laser Technology Congress held in May this year, interest in the topic of process control was greater than expected. Appropriately, the event was also used to launch the Industry Working Group for Process Control in Laser Material Processing. The group provides a forum for representatives from industry and research to initiate pre-competitive projects and discuss issues such as standards, potential cost savings and feasibility.

In the age of industry 4.0, laser technology is firmly established within manufacturing. A wide variety of laser techniques – from USP ablation and additive...

Im Focus: New laser joining technologies at ‘K 2016’ trade fair

Every three years, the plastics industry gathers at K, the international trade fair for plastics and rubber in Düsseldorf. The Fraunhofer Institute for Laser Technology ILT will also be attending again and presenting many innovative technologies, such as for joining plastics and metals using ultrashort pulse lasers. From October 19 to 26, you can find the Fraunhofer ILT at the joint Fraunhofer booth SC01 in Hall 7.

K is the world’s largest trade fair for the plastics and rubber industry. As in previous years, the organizers are expecting 3,000 exhibitors and more than...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Experts from industry and academia discuss the future mobile telecommunications standard 5G

23.09.2016 | Event News

ICPE in Graz for the seventh time

20.09.2016 | Event News

Using mathematical models to understand our brain

16.09.2016 | Event News

 
Latest News

How to merge two black holes in a simple way

26.09.2016 | Physics and Astronomy

Australian technology installed on world’s largest single-dish radio telescope

26.09.2016 | Physics and Astronomy

New mechanisms uncovered explaining frost tolerance in plants

26.09.2016 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>