Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Natural insecticide identified as potential cancer prevention agent for early stage lung cancer

16.10.2002


Deguelin may inhibit growth of Akt, an essential molecule in the promotion of precancer



The use of deguelin, a natural plant extract most commonly used as an insecticide in Africa and South American, inhibits the growth of precancerous and cancerous lung cells, with no toxic effects on normal cells, according to a study presented today at the first annual Frontiers in Cancer Prevention Research meeting convened by the American Association for Cancer Research. The role of deguelin as an inhibitor of Akt activation has clinical implications, especially in non-small cell lung cancer (NSCLC), where constant activation of Akt occurs. Akt, or protein kinase B, is recognized as one of the most important molecules that promotes the survival of tumor cells by playing the critical role of controlling the balance between survival and apoptosis (programmed cell death).

The study investigated the effects of deguelin on cells representing different stages of lung cancer, and characterized the ways in which deguelin works on precancerous and cancerous human bronchial epithelial (HBE) cells. Deguelin has been isolated from plants such as Mundulea sericea (Leguminosae), which is native to Africa and South America.


"The results of our study provide evidence for the first time that Akt is essential in the growth of precancerous human bronchial epithelial cell line, and that deguelin can be a potential chemopreventive agent against lung cancer," according to Ho-Young Lee, Ph.D., lead investigator of the study, which was conducted by researchers at UT M.D. Anderson Cancer Center.

Several studies have shown that Akt provides a critical cell survival signal for tumor progression by adding phosphate to the proteins involved in cell cycle regulation and pre-cell death factors. Results of this study found that the activation of Akt is a common feature in the early stages of cancer and that inhibition of Akt might be a potential target for chemoprevention. Deguelin is an optimal agent for this goal, according to the results of the study, as it selectively blocked the growth of precancerous and cancerous HBE cells by causing cellular death, with no toxic effects on the HBE cells.

"The role of deguelin as an inhibitor of Akt activation has clinical implications, especially in the prevention and treatment of lung cancer, where controlled activation of Akt occurs at a high frequency" said Dr. Lee. "The manipulation of Akt activity alters the sensitivity of NSCLC cells to chemotherapy and irradiation. Therefore, targeting Akt using deguelin may enhance the effectiveness of chemotherapy and radiation therapy and increase the apoptotic potential of NSCLC cells."

The goal of chemoprevention for lung and other cancers is development of a specifically targeted agent with minimal toxicity that will delay, block or reverse cancer development.

An estimated 169,400 new cases of lung cancer will be diagnosed in 2002, accounting for 13 percent of cancer diagnoses, according to the American Cancer Society. Non-small cell lung cancer accounts for 75 to 80 percent of all lung cancer cases. Lung cancer will claim the lives of more than 154,900 men and women this year, accounting for 28 percent of all cancer deaths. Since 1987, more women have died each year from lung cancer than breast cancer, which, for over 40 years, was the major cause of cancer death in women. It is estimated that approximately 65,700 women will die from lung cancer and 39,600 women will die from breast cancer in 2002.

Aimee Frank | EurekAlert!
Further information:
http://www.aacr.org/

More articles from Health and Medicine:

nachricht Monitoring the heart's mitochondria to predict cardiac arrest?
21.09.2017 | Boston Children's Hospital

nachricht Highly precise wiring in the Cerebral Cortex
21.09.2017 | Max-Planck-Institut für Hirnforschung

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

Im Focus: Fast, convenient & standardized: New lab innovation for automated tissue engineering & drug

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems Holding GmbH about commercial use of a multi-well tissue plate for automated and reliable tissue engineering & drug testing.

MBM ScienceBridge GmbH successfully negotiated a license agreement between University Medical Center Göttingen (UMG) and the biotech company Tissue Systems...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Comet or asteroid? Hubble discovers that a unique object is a binary

21.09.2017 | Physics and Astronomy

Cnidarians remotely control bacteria

21.09.2017 | Life Sciences

Monitoring the heart's mitochondria to predict cardiac arrest?

21.09.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>