Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Natural insecticide identified as potential cancer prevention agent for early stage lung cancer

16.10.2002


Deguelin may inhibit growth of Akt, an essential molecule in the promotion of precancer



The use of deguelin, a natural plant extract most commonly used as an insecticide in Africa and South American, inhibits the growth of precancerous and cancerous lung cells, with no toxic effects on normal cells, according to a study presented today at the first annual Frontiers in Cancer Prevention Research meeting convened by the American Association for Cancer Research. The role of deguelin as an inhibitor of Akt activation has clinical implications, especially in non-small cell lung cancer (NSCLC), where constant activation of Akt occurs. Akt, or protein kinase B, is recognized as one of the most important molecules that promotes the survival of tumor cells by playing the critical role of controlling the balance between survival and apoptosis (programmed cell death).

The study investigated the effects of deguelin on cells representing different stages of lung cancer, and characterized the ways in which deguelin works on precancerous and cancerous human bronchial epithelial (HBE) cells. Deguelin has been isolated from plants such as Mundulea sericea (Leguminosae), which is native to Africa and South America.


"The results of our study provide evidence for the first time that Akt is essential in the growth of precancerous human bronchial epithelial cell line, and that deguelin can be a potential chemopreventive agent against lung cancer," according to Ho-Young Lee, Ph.D., lead investigator of the study, which was conducted by researchers at UT M.D. Anderson Cancer Center.

Several studies have shown that Akt provides a critical cell survival signal for tumor progression by adding phosphate to the proteins involved in cell cycle regulation and pre-cell death factors. Results of this study found that the activation of Akt is a common feature in the early stages of cancer and that inhibition of Akt might be a potential target for chemoprevention. Deguelin is an optimal agent for this goal, according to the results of the study, as it selectively blocked the growth of precancerous and cancerous HBE cells by causing cellular death, with no toxic effects on the HBE cells.

"The role of deguelin as an inhibitor of Akt activation has clinical implications, especially in the prevention and treatment of lung cancer, where controlled activation of Akt occurs at a high frequency" said Dr. Lee. "The manipulation of Akt activity alters the sensitivity of NSCLC cells to chemotherapy and irradiation. Therefore, targeting Akt using deguelin may enhance the effectiveness of chemotherapy and radiation therapy and increase the apoptotic potential of NSCLC cells."

The goal of chemoprevention for lung and other cancers is development of a specifically targeted agent with minimal toxicity that will delay, block or reverse cancer development.

An estimated 169,400 new cases of lung cancer will be diagnosed in 2002, accounting for 13 percent of cancer diagnoses, according to the American Cancer Society. Non-small cell lung cancer accounts for 75 to 80 percent of all lung cancer cases. Lung cancer will claim the lives of more than 154,900 men and women this year, accounting for 28 percent of all cancer deaths. Since 1987, more women have died each year from lung cancer than breast cancer, which, for over 40 years, was the major cause of cancer death in women. It is estimated that approximately 65,700 women will die from lung cancer and 39,600 women will die from breast cancer in 2002.

Aimee Frank | EurekAlert!
Further information:
http://www.aacr.org/

More articles from Health and Medicine:

nachricht Finnish research group discovers a new immune system regulator
23.02.2018 | University of Turku

nachricht Minimising risks of transplants
22.02.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Attoseconds break into atomic interior

A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.

In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...

Im Focus: Good vibrations feel the force

A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.

By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...

Im Focus: Developing reliable quantum computers

International research team makes important step on the path to solving certification problems

Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Basque researchers turn light upside down

23.02.2018 | Physics and Astronomy

Finnish research group discovers a new immune system regulator

23.02.2018 | Health and Medicine

Attoseconds break into atomic interior

23.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>