Deguelin may inhibit growth of Akt, an essential molecule in the promotion of precancer
The use of deguelin, a natural plant extract most commonly used as an insecticide in Africa and South American, inhibits the growth of precancerous and cancerous lung cells, with no toxic effects on normal cells, according to a study presented today at the first annual Frontiers in Cancer Prevention Research meeting convened by the American Association for Cancer Research. The role of deguelin as an inhibitor of Akt activation has clinical implications, especially in non-small cell lung cancer (NSCLC), where constant activation of Akt occurs. Akt, or protein kinase B, is recognized as one of the most important molecules that promotes the survival of tumor cells by playing the critical role of controlling the balance between survival and apoptosis (programmed cell death).
The study investigated the effects of deguelin on cells representing different stages of lung cancer, and characterized the ways in which deguelin works on precancerous and cancerous human bronchial epithelial (HBE) cells. Deguelin has been isolated from plants such as Mundulea sericea (Leguminosae), which is native to Africa and South America.
Aimee Frank | EurekAlert!
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