Patterns of proteins found in patients blood serum may help distinguish between prostate cancer and benign conditions, scientists from the National Cancer Institute (NCI) and the Food and Drug Administration (FDA) report today in the Journal of the National Cancer Institute*. The technique, which relies on a simple test using a drop of blood, may be useful in deciding whether to perform a biopsy in men with elevated prostate specific antigen (PSA) levels.
Using a test that can analyze the patterns of small proteins in blood serum samples in just 30 minutes, researchers were able to differentiate between samples taken from patients diagnosed with cancer and those from patients diagnosed with benign prostate disease. The technique proved effective not only in men with normal and high PSA levels, but also in those whose PSA levels were marginally elevated (4 to 10 nanograms of antigen per milliliter of fluid), in whom it is difficult to rule out cancer without a biopsy.
Although the technique is still under evaluation, researchers believe the analysis of protein patterns will be a useful tool in the future for deciding whether men with marginally elevated PSA levels should undergo biopsy. PSA levels are commonly used as a preliminary screen for prostate cancer, but 70 percent to 75 percent of men who undergo biopsy because of an abnormal PSA level do not have cancer. The new proteomic approach has a higher specificity - that is, of the samples the test identifies as cancer, a large percentage are in fact cancer, rather than some other benign disease.
NCI Press Office | EurekAlert!
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An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.
The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...
In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
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