Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Protein patterns in blood may predict prostate cancer diagnosis

16.10.2002


Patterns of proteins found in patients’ blood serum may help distinguish between prostate cancer and benign conditions, scientists from the National Cancer Institute (NCI) and the Food and Drug Administration (FDA) report today in the Journal of the National Cancer Institute*. The technique, which relies on a simple test using a drop of blood, may be useful in deciding whether to perform a biopsy in men with elevated prostate specific antigen (PSA) levels.



Using a test that can analyze the patterns of small proteins in blood serum samples in just 30 minutes, researchers were able to differentiate between samples taken from patients diagnosed with cancer and those from patients diagnosed with benign prostate disease. The technique proved effective not only in men with normal and high PSA levels, but also in those whose PSA levels were marginally elevated (4 to 10 nanograms of antigen per milliliter of fluid), in whom it is difficult to rule out cancer without a biopsy.

Although the technique is still under evaluation, researchers believe the analysis of protein patterns will be a useful tool in the future for deciding whether men with marginally elevated PSA levels should undergo biopsy. PSA levels are commonly used as a preliminary screen for prostate cancer, but 70 percent to 75 percent of men who undergo biopsy because of an abnormal PSA level do not have cancer. The new proteomic approach has a higher specificity - that is, of the samples the test identifies as cancer, a large percentage are in fact cancer, rather than some other benign disease.


"For men with marginally elevated PSA levels, the specificity of the test is 71 percent, as opposed to a very low specificity for PSA in this range," said Emanuel Petricoin III, Ph.D., of the FDA’s Center for Biologics Evaluation and Research, the first author of the study. "We hope that by using proteomic pattern analysis screening in combination with other screening methods, we can reduce the number of unnecessary biopsies for prostate cancer in the future."

The diagnostic test relied on computer software that detects key patterns of small proteins in the blood. Researchers analyzed serum proteins with mass spectroscopy, a technique used to sort proteins and other molecules based on their weight and electrical charge. They then used an artificial intelligence program developed by Correlogic Systems, Inc., in Bethesda, Md., to train a computer to identify patterns of proteins that differed between patients with prostate cancer and those in which a biopsy had found no evidence of disease. These patterns were identified using serum samples from 56 patients who had undergone a biopsy and whose disease status was known.

Once established, the protein patterns were then used to predict diagnosis in a separate group of patients, whose biopsy results were not known by the researchers. From this group, researchers were able to correctly identify 36 of 38 (95 percent) cases of prostate cancer and 177 of 228 (78 percent) cases of benign disease.

The study follows up on the recent finding by the same research group that protein patterns in serum can be used to detect ovarian cancer.

"We have now demonstrated that combining proteomic technology with artificial intelligence based bioinformatics can be a powerful tool, and is a new paradigm in the detection and diagnosis of both ovarian and prostate cancers," said Lance Liotta, M.D., Ph.D., the senior investigator on the study from NCI’s Center for Cancer Research. "We are extremely optimistic that this new approach will prove useful in detecting and diagnosing many other cancers and diseases in the future."

NCI Press Office | EurekAlert!
Further information:
http://www.cancer.gov.

More articles from Health and Medicine:

nachricht New study points the way to therapy for rare cancer that targets the young
22.11.2017 | Rockefeller University

nachricht Penn study identifies new malaria parasites in wild bonobos
21.11.2017 | University of Pennsylvania School of Medicine

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Frictional Heat Powers Hydrothermal Activity on Enceladus

Computer simulation shows how the icy moon heats water in a porous rock core

Heat from the friction of rocks caused by tidal forces could be the “engine” for the hydrothermal activity on Saturn's moon Enceladus. This presupposes that...

Im Focus: Nanoparticles help with malaria diagnosis – new rapid test in development

The WHO reports an estimated 429,000 malaria deaths each year. The disease mostly affects tropical and subtropical regions and in particular the African continent. The Fraunhofer Institute for Silicate Research ISC teamed up with the Fraunhofer Institute for Molecular Biology and Applied Ecology IME and the Institute of Tropical Medicine at the University of Tübingen for a new test method to detect malaria parasites in blood. The idea of the research project “NanoFRET” is to develop a highly sensitive and reliable rapid diagnostic test so that patient treatment can begin as early as possible.

Malaria is caused by parasites transmitted by mosquito bite. The most dangerous form of malaria is malaria tropica. Left untreated, it is fatal in most cases....

Im Focus: A “cosmic snake” reveals the structure of remote galaxies

The formation of stars in distant galaxies is still largely unexplored. For the first time, astron-omers at the University of Geneva have now been able to closely observe a star system six billion light-years away. In doing so, they are confirming earlier simulations made by the University of Zurich. One special effect is made possible by the multiple reflections of images that run through the cosmos like a snake.

Today, astronomers have a pretty accurate idea of how stars were formed in the recent cosmic past. But do these laws also apply to older galaxies? For around a...

Im Focus: Visual intelligence is not the same as IQ

Just because someone is smart and well-motivated doesn't mean he or she can learn the visual skills needed to excel at tasks like matching fingerprints, interpreting medical X-rays, keeping track of aircraft on radar displays or forensic face matching.

That is the implication of a new study which shows for the first time that there is a broad range of differences in people's visual ability and that these...

Im Focus: Novel Nano-CT device creates high-resolution 3D-X-rays of tiny velvet worm legs

Computer Tomography (CT) is a standard procedure in hospitals, but so far, the technology has not been suitable for imaging extremely small objects. In PNAS, a team from the Technical University of Munich (TUM) describes a Nano-CT device that creates three-dimensional x-ray images at resolutions up to 100 nanometers. The first test application: Together with colleagues from the University of Kassel and Helmholtz-Zentrum Geesthacht the researchers analyzed the locomotory system of a velvet worm.

During a CT analysis, the object under investigation is x-rayed and a detector measures the respective amount of radiation absorbed from various angles....

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Ecology Across Borders: International conference brings together 1,500 ecologists

15.11.2017 | Event News

Road into laboratory: Users discuss biaxial fatigue-testing for car and truck wheel

15.11.2017 | Event News

#Berlin5GWeek: The right network for Industry 4.0

30.10.2017 | Event News

 
Latest News

Desert ants cannot be fooled

23.11.2017 | Life Sciences

By saving cost and energy, the lighting revolution may increase light pollution

23.11.2017 | Earth Sciences

Retreating permafrost coasts threaten the fragile Arctic environment

23.11.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>