Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers track elusive brain tumor cells in mice with neural stem cells modified to deliver IL-12

15.10.2002


Findings are cover story of Oct. 15 issue of Cancer Research



Researchers at Cedars-Sinai Medical Center’s Maxine Dunitz Neurosurgical Institute have successfully tested a new treatment for brain cancer by utilizing neural stem cells to track and destroy cancer cells within the brain. Scientists hope the encouraging results may eventually lead to an effective treatment for glioma, the most aggressive form of primary brain tumor in humans. The study, conducted in mice with experimental brain cancer, is featured on the cover of the Oct. 15 issue of the journal Cancer Research.

The prognosis has historically been extremely poor for patients diagnosed with malignant gliomas. These tumors have very poorly defined margins, and glioma cells often spread deep into healthy brain tissue making their effective surgical removal extremely difficult. Often, pockets of tumor cells break off from the main tumor and migrate deep into non-tumorous areas of the brain. Therefore, even if the original tumor is completely removed or destroyed, the risk of recurrence is high as cells in these distant "satellites" multiply and eventually re-form a new brain tumor. Due to these characteristics, treating brain cancer has been extremely difficult.


The new experimental treatment involves the use of neural stem cells for tracking and targeting brain tumor cells that spread out into normal brain. Scientists show that neural stem cells, when injected into brain tumors, can follow tumor cells as they migrate away from the main tumor mass. This capability led scientists to genetically engineer neural stem cells to produce interleukin 12, an immune stimulating chemical known to kill glioma cells. The interleukin 12 producing neural stem cells were then injected into brain tumors in mice and could kill tumor cells that had spread deep into normal brain tissue, at considerable distance from the primary tumor. Mice treated with this novel strategy survived significantly longer than control-treated mice. In fact, 30% of animals treated in this new manner developed long-term immunity to brain cancer, indicating the potency of this therapy.

Scientists demonstrated that the neural stem cells were able to kill the spreading tumor cells by delivering interleukin 12 directly to these migrating glioma "satellites". Previous research at the Maxine Dunitz Neurosurgical Institute has demonstrated that interleukin 12 can activate cancer killing cells from the immune system to attack and destroy brain tumor cells. The ability of neural stem cells to deliver this immune stimulating protein directly to small pockets of brain tumor cells that can not be accessed using surgery, represents a promising new method that could be used to eliminate all remaining tumor left behind after routine surgery. This could hopefully lower the incidence of tumor recurrence and improve survival in patients with malignant gliomas.

"The current focus of experimental neural stem cell therapeutics is primarily based around their use in the treatment of neurodegenerative disorders and stroke. We have demonstrated that combining the tumoricidal potency of interleukin 12 with the extensive tumor tracing capability of neural stem cells, results in a synergistic therapeutic benefit," according to the authors. "This further extends the scope of neural stem cell therapy to include their use as vehicles for protein delivery to in vivo glioma, and therefore represents a promising new treatment modality for malignant brain tumors."

Sandra Van | EurekAlert!
Further information:
http://www.csmc.edu/

More articles from Health and Medicine:

nachricht Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>