Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Neural stem cells improve motor function in brain injuries

02.10.2002


Transplants in animal models could translate into therapy for humans

Neural stem cells, transplanted into injured brains, survive, proliferate, and improve brain function in laboratory models according to research based at the University of Pennsylvania School of Medicine. The findings, published in the October edition of the journal Neurosurgery, suggest that stem cells could provide the first clinical therapy to treat traumatic brain injuries. Traumatic brain injuries occur in two million Americans each year and are the leading cause of long-term neurological disability in children and young adults.

"Transplantation of neural stem cells in mice three days after brain injury promotes the improvement of specific components of motor function," said Tracy K. McIntosh, PhD, professor in the Department of Neurosurgery, Director of Penn’s Head Injury Center, and senior author of the study. "More importantly, these stem cells respond to signals and create replacement cells: both neurons, which transmit nerve signals, and glial cells, which serve many essential supportive roles in the nervous system."



If stem cells are blank slates, able to become any type of body cells, then neural stem cells (NSCs) are slates with the basics of neurology already written on them, waiting for signals in the nervous system to fill in the blanks. The NSCs used by McIntosh and his colleagues were cloned from mouse progenitor cells and grown in culture. The advantage of NSCs exists in their ability to easily incorporate themselves into their new environment in ways other types of transplants could not.

"If you put these cells into normal newborn mice, they would behave exactly like normal cells – they create different neural cell types and they don’t reproduce tumorigenically," said McIntosh. "In humans, the use of similar neural stem cells would avoid the ethical dilemmas posed by fetal stem cells and the limitations seen in cultures of cloned neurons."

In humans, traumatic brain injury is associated with disabilities affecting mobility, motor function and coordination. Following NSC transplantation in mice, the researchers used simple tests to determine motor skills. They found that mice with transplanted NSCs recovered much of their physical ability. The transplanted NSCs, however, seemed to have little effect in aiding recovery of lost cognitive abilities.

"The ultimate goal, of course, is to translate what we have learned into a therapy for humans," said McIntosh. Neural transplantation has been suggested to be potentially useful as a therapeutic intervention in several central nervous system diseases including Parkinson’s disease, Huntington’s disease, ischemic brain injury, and spinal cord injury. While McIntosh is impressed with the results of NSC transplants in mice, similar trials for humans are not expected in the near future.

Greg Lester | EurekAlert!
Further information:
http://www.med.upenn.edu/

More articles from Health and Medicine:

nachricht Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University

nachricht The first analysis of Ewing's sarcoma methyloma opens doors to new treatments
01.12.2016 | IDIBELL-Bellvitge Biomedical Research Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>