Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Research reveals a more complete picture of breast tissue

17.09.2002


A team of Dartmouth engineers and doctors are trying to find more comfortable and comprehensive ways to examine breast tissue to better detect and diagnose breast cancer. The Dartmouth group is simultaneously developing and testing four different breast imaging techniques.



The multidisciplinary Dartmouth team includes researchers from the Thayer School of Engineering and Dartmouth Medical School, and they are working under the auspices of the Norris Cotton Cancer Center and the department of radiology at Dartmouth-Hitchcock Medical Center. Halfway through their five-year, $7 million grant from the National Cancer Institute to study four techniques for breast imaging, the group is learning a great deal about breast tissue structure and behavior through magnetic resonance elastography (MRE), electrical impedance spectral imaging (EIS), microwave imaging spectroscopy (MIS), and near infrared (NIR) spectral imaging.

It’s the combination of these four techniques that sets the Dartmouth program apart. Their rationale is that one of the methods by itself may not provide the complete picture, but by using more than one technique, there should be added value.


"I think we’re the only group looking at these four methods simultaneously," says Keith Paulsen, engineering professor and one of the principal investigators with the Breast Imaging Project.

By collaborating across disciplines, the researchers have been able to take prototype equipment from the drawing board, to the laboratory, to the patient relatively quickly.

"The research is preliminary, but we are progressing," says Steven Poplack, associate professor of radiology and of obstetrics and gynecology. "We’re still gathering basic information about the clinical characteristics of normal breast tissue. Once we know what’s normal, we can then start working on recognizing what’s abnormal."

The new imaging methods are not invasive nor particularly uncomfortable for participants, and they all provide more detailed information about different properties of breast tissue.

"We hope our research can answer some of the anatomical and physiological questions," says Paulsen. "Our data provides quantitative information, and we hope to determine a threshold value that indicates an abnormality."

The four different techniques:

  • MRE: Using a magnetic resonance machine (the same one used in MRI exams), this test measures tissue hardness or elasticity. While in "the magnet," the breast tissue vibrates 100 times a second with very small amplitudes of less than a millimeter to determine how the tissue moves. The exam provides an image with corresponding numerical values for each portion of the breast.
  • EIS: This painless test uses a very low voltage electrode system to examine how the breast tissue conducts and stores electricity. Living cell membranes carry an electric potential that affect the way a current flows, and different cancer cells have different electrical characteristics.
  • MIS: This exam involves the propagation of very low levels (1000 times less than a cell phone) of microwave energy through breast tissue to measure electrical properties. This technique is particularly sensitive to water. Generally, tumors have been found to have more water and blood than regular tissue.
  • NIR: Infrared light is sensitive to blood, so by sending infrared light through breast tissue with a fiber optic array, the researchers are able to locate and quantify regions of oxygenated and deoxygenated hemoglobin. This might help detect early tumor growth and characterize the stage of a tumor by learning about its vascular makeup. Different levels of blood vessel activity in a tumor influence the effectiveness of treatment, so knowing the vascularity stage of a tumor should help design better treatment regimes.

During the first two and a half years of this five-year National Cancer Institute grant, the group has made significant progress on the technical aspects of the imaging techniques. They have improved the tools and manner of delivery so the exams are more comfortable for the participants.

For the next two and a half years, the researchers will focus on a controlled trial with 150 subjects. The goal is to rigorously test the four techniques and gather data to inform the detection of abnormalities and their subsequent diagnoses.

Sue Knapp | EurekAlert!
Further information:
http://www.dartmouth.edu/~news/releases/sept02/imaging.shtml

More articles from Health and Medicine:

nachricht Custom-tailored strategy against glioblastomas
26.09.2016 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New leukemia treatment offers hope
23.09.2016 | King Abdullah University of Science and Technology

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: New welding process joins dissimilar sheets better

Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of light metals.
Scientists at the University of Stuttgart have now developed two new process variants that will considerably expand the areas of application for friction stir welding.
Technologie-Lizenz-Büro (TLB) GmbH supports the University of Stuttgart in patenting and marketing its innovations.

Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of...

Im Focus: First quantum photonic circuit with electrically driven light source

Optical quantum computers can revolutionize computer technology. A team of researchers led by scientists from Münster University and KIT now succeeded in putting a quantum optical experimental set-up onto a chip. In doing so, they have met one of the requirements for making it possible to use photonic circuits for optical quantum computers.

Optical quantum computers are what people are pinning their hopes on for tomorrow’s computer technology – whether for tap-proof data encryption, ultrafast...

Im Focus: OLED microdisplays in data glasses for improved human-machine interaction

The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.

“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...

Im Focus: Artificial Intelligence Helps in the Discovery of New Materials

With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.

Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...

Im Focus: Complex hardmetal tools out of the 3D printer

For the first time, Fraunhofer IKTS shows additively manufactured hardmetal tools at WorldPM 2016 in Hamburg. Mechanical, chemical as well as a high heat resistance and extreme hardness are required from tools that are used in mechanical and automotive engineering or in plastics and building materials industry. Researchers at the Fraunhofer Institute for Ceramic Technologies and Systems IKTS in Dresden managed the production of complex hardmetal tools via 3D printing in a quality that are in no way inferior to conventionally produced high-performance tools.

Fraunhofer IKTS counts decades of proven expertise in the development of hardmetals. To date, reliable cutting, drilling, pressing and stamping tools made of...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Paper – Panacea Green Infrastructure?

30.09.2016 | Event News

HLF: From an experiment to an establishment

29.09.2016 | Event News

European Health Forum Gastein 2016 kicks off today

28.09.2016 | Event News

 
Latest News

Cells migrate collectively by intermittent bursts of activity

30.09.2016 | Life Sciences

The structure of the BinAB toxin revealed: one small step for Man, a major problem for mosquitoes!

30.09.2016 | Life Sciences

Researcher creates a controlled rogue wave in realistic oceanic conditions

30.09.2016 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>