Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

OHSU researchers discover toxicity risks for widely used chemicals

16.09.2002


Research at Oregon Health & Science University (OHSU) has revealed that certain chemical ingredients of gasoline, jet fuel and other solvents may pose a greater health hazard than first thought. Scientists at the OHSU Center for Research on Occupational and Environmental Toxicology (CROET) have shown that a benzene derivative damages the nervous system. In fact, the substance is much more active than non-benzene analogs already known to cause peripheral nerve damage (loss of limb sensation and muscle weakness) in solvent-exposed workers. The research team was led by Mohammad Sabri, Ph.D., and Peter Spencer, Ph.D., F.R.C. Path., of OHSU. The conclusions of the research are printed in the September 2002 issue of the Journal of Toxicology and Applied Pharmacology.

"Previously, researchers believed that benzene derivatives were unable to damage the nervous system," said Spencer. "The substance we studied - 1,2-diacetylbenzene - has a ring-like (aromatic) chemical structure in contrast to the straight-chain (aliphatic) solvents that are well established causes of occupation-related nerve damage. Our data suggest the aromatic substance actually has a much higher neurotoxic potency. In addition, the new findings raise the possibility that related aromatic chemicals may also damage the nervous system. We believe these substances should be tested for neurotoxicity, and occupational exposures should be regulated to prevent illness among workers who come in contact with these chemicals."

One of these related aromatic chemicals, a substance known as Musk tetralin, was used until the 1980s by the fragrance industry to hide product odor in soaps and fragrances. The industry voluntarily withdrew Musk tetralin worldwide after Spencer and fellow researchers demonstrated the substance was neurotoxic. Because aromatic hydrocarbons have been used in such large quantities by the public and in commerce, the chemicals are now common soil and water contaminants.



"One surprising property of these neurotoxic substances, including Musk tetralin and 1,2-diacetylbenzene, is their ability to cause blue discoloration of tissue and urine to turn green. Perhaps this property could be used as a biological marker of exposure to these hazardous substances," said Sabri. "We hope to develop a method by which urine or other fluids can be tested for the presence of the blue pigment. Since urine discoloration occurs before neurological disease, it may serve to help prevent onset of disease among those exposed to these substances in the workplace or at contaminated sites."

The research was conducted through the OHSU/CROET Superfund Basic Research Program and NeuroToxicogenomics Research Center, both funded by the National Institute for Environmental Health Sciences, a component of the National Institutes of Health. Leadership of both of these research centers resides in CROET.

Specifics:
Peter Spencer, Ph.D., F.R.C.Path., senior scientist and director, CROET; principal investigator, NIEHS-supported Superfund Basic Research Center; principal investigator, NIEHS-supported Neurotoxicogenomics and Child Health Research Center; and professor of neurology, OHSU School of Medicine

Mohammad I. Sabri, Ph.D., associate professor of neurology, OHSU School of Medicine; senior investigator, CROET For a complete listing of OHSU press releases, visit www.ohsu.edu/news

Jim Newman | EurekAlert!
Further information:
http://www.ohsu.edu/

More articles from Health and Medicine:

nachricht Oxygen can wake up dormant bacteria for antibiotic attacks
08.12.2016 | Penn State

nachricht NTU scientists build new ultrasound device using 3-D printing technology
07.12.2016 | Nanyang Technological University

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Significantly more productivity in USP lasers

In recent years, lasers with ultrashort pulses (USP) down to the femtosecond range have become established on an industrial scale. They could advance some applications with the much-lauded “cold ablation” – if that meant they would then achieve more throughput. A new generation of process engineering that will address this issue in particular will be discussed at the “4th UKP Workshop – Ultrafast Laser Technology” in April 2017.

Even back in the 1990s, scientists were comparing materials processing with nanosecond, picosecond and femtosesecond pulses. The result was surprising:...

Im Focus: Shape matters when light meets atom

Mapping the interaction of a single atom with a single photon may inform design of quantum devices

Have you ever wondered how you see the world? Vision is about photons of light, which are packets of energy, interacting with the atoms or molecules in what...

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

Closing the carbon loop

08.12.2016 | Life Sciences

Applicability of dynamic facilitation theory to binary hard disk systems

08.12.2016 | Physics and Astronomy

Scientists track chemical and structural evolution of catalytic nanoparticles in 3-D

08.12.2016 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>