The inflammatory myopathies comprise three different entities: polymyositis, inclusion body myositis and dermatomyositis. People in all age groups can be affected by major muscle weakness and pain, and show evidence of muscle fiber breakdown in the serum. Autoimmune pathogenetic mechanisms have been identified in each inflammatory myopathy, but the antigen(s) recognized by the autoreactive inflammatory cells and the factors eliciting the aberrant immune responses remain unknown. Currently, patients are treated with corticosteroids with variable success rates and at a high cost of side-effects.
The ongoing research is aimed at identifying the factors that guide the trafficking of inflammatory cells from the blood to the inflamed muscle tissue. A new study reports the differential expression of chemokines and their receptors in each inflammatory myopathy. Chemokines represent a family of small-molecular weight cytokines that have an important role in the migration of distinct leukocyte subsets to the sites of inflammation. The chemokines monocyte chemoattractant protein-1 (MCP-1) and stromal derived factor (SDF-1a and SDF-1b) and their receptors are strongly expressed whereas a number of others are undetectable.
Blocking the autoimmune cascade by targeting chemokines or chemokine receptors has given excellent results in animal models of other immune diseases. The present work identifies the candidates for selective immune intervention in patients suffering autoimmune inflammatory myopathies and may well lead to more selective treatment modalities with less side-effects than the currently available drugs.
Jan DE BLEECKER | alfa
Custom-tailored strategy against glioblastomas
26.09.2016 | Rheinische Friedrich-Wilhelms-Universität Bonn
New leukemia treatment offers hope
23.09.2016 | King Abdullah University of Science and Technology
Heavy construction machinery is the focus of Oak Ridge National Laboratory’s latest advance in additive manufacturing research. With industry partners and university students, ORNL researchers are designing and producing the world’s first 3D printed excavator, a prototype that will leverage large-scale AM technologies and explore the feasibility of printing with metal alloys.
Increasing the size and speed of metal-based 3D printing techniques, using low-cost alloys like steel and aluminum, could create new industrial applications...
Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of light metals.
Scientists at the University of Stuttgart have now developed two new process variants that will considerably expand the areas of application for friction stir welding.
Technologie-Lizenz-Büro (TLB) GmbH supports the University of Stuttgart in patenting and marketing its innovations.
Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of...
Optical quantum computers can revolutionize computer technology. A team of researchers led by scientists from Münster University and KIT now succeeded in putting a quantum optical experimental set-up onto a chip. In doing so, they have met one of the requirements for making it possible to use photonic circuits for optical quantum computers.
Optical quantum computers are what people are pinning their hopes on for tomorrow’s computer technology – whether for tap-proof data encryption, ultrafast...
The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.
“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...
With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.
Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...
30.09.2016 | Event News
29.09.2016 | Event News
28.09.2016 | Event News
30.09.2016 | Materials Sciences
30.09.2016 | Earth Sciences
30.09.2016 | Life Sciences