Combining the tumor suppressing Rb2 gene with doses of gamma radiation speeds up the ability of tumor cells to die, according to a study by researchers at Temple Universitys College of Science and Technology.
Photo Credit: Joseph V. Labolito
Antonio Giordano, M.D., Ph.D., an internationally recognized researcher in the genetics of cancer and gene therapy, joined the faculty of Temple Universitys College of Science and Technology (CST) on March
The results of the study, "pRb2/p130 promotes radiation-induced death in glioblastoma cell line HJC12 by p73 upregulation and Bcl-2 downregulation," appear in the August 29 issue of Oncogene (Vol. 21, Issue 38).
In the study, which was started at Thomas Jefferson University and completed at Temples Sbarro Institute for Cancer Research and Molecular Medicine, the researchers found that when they treated tumor cells in which the Rb2 gene has been transplanted with gamma radiation, there was an increase of almost 50 percent in the ability of the cells to destroy themselves.
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