Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Verbal memory test best indicator of who will have Alzheimer’s disease, new study says

26.08.2002


Early Detection of Alzheimer’s Could Lessen the Impact



Incidence of Alzheimer’s Disease is expected to increase as the population of elderly grows. Early diagnosis and treatment will be the key to lessening the disease’s worst effects, but, how to spot the disease before its symptoms become serious (and harm is already done) is a challenge for health professionals. A new study by psychologists Konstantine K. Zakzanis, Ph.D., and Mark Boulos, B.Sc., of the University of Toronto has determined that the best predictor of future Alzheimer’s type dementia is a verbal memory test. Their study will be presented in Chicago at the 110th Annual Convention of the American Psychological Association (APA).

In a meta-analysis of 31 studies amounting to 1,144 Alzheimer’s patients and 6,046 healthy controls, Zakzanis and Boulos looked at both neuropsychological and neuroimaging tests to determine their ability to detect preclinical dementia and/or Alzheimer’s disease. They also paired a genetic susceptibility (presence of the ApoE gene) to dementia/Alzheimer’s with results on both neuropsychological and neuroanatomic tests again attempting to identify which types of tests would prove most accurate in identifying preclinical disease in patients with the ApoE gene.


Specifically, their findings support the use of the California Verbal Learning Test (long delay recall and percent recall) as the best predictor of Alzheimer’s type dementia, with executive function type measures also being predictive but less so than both the long and short delay memory tests.

Changes in the hippocampus were the best volumetric or neuroimaging measure but in general volumetric measures were less sensitive to preclinical stages of the dementia than were the neuropsychological tests.

Ironically, while memory assessments were also more predictive of preclinical Alzheimer’s than neuroimaging tests for people with the ApoE gene, the most predictive test for such persons still appears to be an odor identification test.

In presenting their findings, the authors note that decline in memory, especially in verbal episodic memory, can be observed in normal elderly people as well as in elderly with mild cognitive impairments and that most of those people will not become future victims of Alzheimer’s. How can we tell the difference between those elderly with normal memory impairments and those with preclinical Alzheimer’s? The answer, according to the researchers, lies in the magnitude of the memory deficit. Because their study was a meta-analysis of effect sizes, the results allowed them to compare the size of the difference between normal older adults with normal memory decline and older adults with actual dementia.

Presentation: "A Meta-Analysis of ApoE Genotype and Neuropsychologic and Neuroanatomic Changes in Preclinical Alzheimer’s Disease," Konstantine K. Zakzanis, Ph.D., University of Toronto, and Mark I. Boulos, B.Sc., University of Toronto, Session 4140, 10:00 - 11:50 AM, August 25, 2002, McCormick Place, Lakeside Center-Level 4, Meeting Room E451a.

APA Public Affairs Office | EurekAlert!
Further information:
http://www.apa.org/

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>