Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

High levels of C-reactive protein indicate early heart disease

20.08.2002


Using a simple, inexpensive test to determine levels of C-reactive protein in the blood, researchers were able to detect heart disease before symptoms were apparent, according to a report in today’s rapid access issue of Circulation: Journal of the American Heart Association.



Researchers studied the relationship between levels of C-reactive protein (CRP, a marker of inflammation in the body), and coronary calcium, which indicates the extent of atherosclerosis in the coronary arteries. Atherosclerosis, or fatty build-up in the arteries, is a sign of heart disease.

"While the majority of men and women in our study had some calcium in their arteries, the higher the C-reactive protein level, the more calcium they had," says Thomas J. Wang, M.D., lead author of the study and research fellow with the National Heart, Lung, and Blood Institute’s Framingham Heart Study.


Researchers studied 321 people (average age 60) who have participated in the Framingham Heart Study since 1971. They underwent blood tests to determine CRP levels and electron beam computed tomography scans to detect the amount of calcium in their coronary arteries, which is given as a coronary artery calcification (CAC) score.

Participants were divided into five groups, or quintiles, based on their CRP levels. Quintile ranges for CRP were 0-0.04 mg/dL, 0.1-0.8 mg/dL, 0.9- 2.3 mg/dL, 2.4-6.5 mg/dL, and 6.7-48.2 mg/dL. For both men and women, average CAC scores increased with higher levels of CRP.

People with elevated CRP seemed to have or develop more coronary calcium, even after adjusting for age, traditional risk factors and Framingham risk score.

"It has been known that inflammation plays a role in coronary artery disease but the direct link between the level of this marker of inflammation and the actual presence of calcium in the coronary arteries is a new finding," Wang says.

A study limitation was that CRP levels were obtained four to eight years before the imaging scans, which may have blurred the link between atherosclerosis and CRP, says Wang. Future studies should clarify how best to combine the information from CRP tests, imaging studies, and knowledge of traditional risk factors such as high blood pressure, cholesterol and smoking.


###
Co-authors include Martin G. Larson, Sc.D.; Daniel Levy, M.D.; Emelia J. Benjamin, M.D., Sc.M.; Michelle J. Kupka, M.A.; Warren J. Manning, M.D.; Melvin E. Clouse, M.D.; Ralph B. D’Agostino, Ph.D.; Peter W.F. Wilson, M.D.; and Christopher J. O’Donnell, M.D., M.P.H.

This study was funded in part by the National Institutes of Health.

CONTACT: For journal copies only,
please call: (214) 706-1396
For other information, call:
Carole Bullock: (214) 706-1279
Bridgette McNeill: (214) 706-1135

Carole Bullock | EurekAlert!

More articles from Health and Medicine:

nachricht New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia

nachricht New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

A Map of the Cell’s Power Station

18.08.2017 | Life Sciences

Engineering team images tiny quasicrystals as they form

18.08.2017 | Physics and Astronomy

Researchers printed graphene-like materials with inkjet

18.08.2017 | Materials Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>