Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

High levels of C-reactive protein indicate early heart disease

20.08.2002


Using a simple, inexpensive test to determine levels of C-reactive protein in the blood, researchers were able to detect heart disease before symptoms were apparent, according to a report in today’s rapid access issue of Circulation: Journal of the American Heart Association.



Researchers studied the relationship between levels of C-reactive protein (CRP, a marker of inflammation in the body), and coronary calcium, which indicates the extent of atherosclerosis in the coronary arteries. Atherosclerosis, or fatty build-up in the arteries, is a sign of heart disease.

"While the majority of men and women in our study had some calcium in their arteries, the higher the C-reactive protein level, the more calcium they had," says Thomas J. Wang, M.D., lead author of the study and research fellow with the National Heart, Lung, and Blood Institute’s Framingham Heart Study.


Researchers studied 321 people (average age 60) who have participated in the Framingham Heart Study since 1971. They underwent blood tests to determine CRP levels and electron beam computed tomography scans to detect the amount of calcium in their coronary arteries, which is given as a coronary artery calcification (CAC) score.

Participants were divided into five groups, or quintiles, based on their CRP levels. Quintile ranges for CRP were 0-0.04 mg/dL, 0.1-0.8 mg/dL, 0.9- 2.3 mg/dL, 2.4-6.5 mg/dL, and 6.7-48.2 mg/dL. For both men and women, average CAC scores increased with higher levels of CRP.

People with elevated CRP seemed to have or develop more coronary calcium, even after adjusting for age, traditional risk factors and Framingham risk score.

"It has been known that inflammation plays a role in coronary artery disease but the direct link between the level of this marker of inflammation and the actual presence of calcium in the coronary arteries is a new finding," Wang says.

A study limitation was that CRP levels were obtained four to eight years before the imaging scans, which may have blurred the link between atherosclerosis and CRP, says Wang. Future studies should clarify how best to combine the information from CRP tests, imaging studies, and knowledge of traditional risk factors such as high blood pressure, cholesterol and smoking.


###
Co-authors include Martin G. Larson, Sc.D.; Daniel Levy, M.D.; Emelia J. Benjamin, M.D., Sc.M.; Michelle J. Kupka, M.A.; Warren J. Manning, M.D.; Melvin E. Clouse, M.D.; Ralph B. D’Agostino, Ph.D.; Peter W.F. Wilson, M.D.; and Christopher J. O’Donnell, M.D., M.P.H.

This study was funded in part by the National Institutes of Health.

CONTACT: For journal copies only,
please call: (214) 706-1396
For other information, call:
Carole Bullock: (214) 706-1279
Bridgette McNeill: (214) 706-1135

Carole Bullock | EurekAlert!

More articles from Health and Medicine:

nachricht New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM

nachricht A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Scientist invents way to trigger artificial photosynthesis to clean air

26.04.2017 | Materials Sciences

Ammonium nitrogen input increases the synthesis of anticarcinogenic compounds in broccoli

26.04.2017 | Agricultural and Forestry Science

SwRI-led team discovers lull in Mars' giant impact history

26.04.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>