Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

High levels of C-reactive protein indicate early heart disease

20.08.2002


Using a simple, inexpensive test to determine levels of C-reactive protein in the blood, researchers were able to detect heart disease before symptoms were apparent, according to a report in today’s rapid access issue of Circulation: Journal of the American Heart Association.



Researchers studied the relationship between levels of C-reactive protein (CRP, a marker of inflammation in the body), and coronary calcium, which indicates the extent of atherosclerosis in the coronary arteries. Atherosclerosis, or fatty build-up in the arteries, is a sign of heart disease.

"While the majority of men and women in our study had some calcium in their arteries, the higher the C-reactive protein level, the more calcium they had," says Thomas J. Wang, M.D., lead author of the study and research fellow with the National Heart, Lung, and Blood Institute’s Framingham Heart Study.


Researchers studied 321 people (average age 60) who have participated in the Framingham Heart Study since 1971. They underwent blood tests to determine CRP levels and electron beam computed tomography scans to detect the amount of calcium in their coronary arteries, which is given as a coronary artery calcification (CAC) score.

Participants were divided into five groups, or quintiles, based on their CRP levels. Quintile ranges for CRP were 0-0.04 mg/dL, 0.1-0.8 mg/dL, 0.9- 2.3 mg/dL, 2.4-6.5 mg/dL, and 6.7-48.2 mg/dL. For both men and women, average CAC scores increased with higher levels of CRP.

People with elevated CRP seemed to have or develop more coronary calcium, even after adjusting for age, traditional risk factors and Framingham risk score.

"It has been known that inflammation plays a role in coronary artery disease but the direct link between the level of this marker of inflammation and the actual presence of calcium in the coronary arteries is a new finding," Wang says.

A study limitation was that CRP levels were obtained four to eight years before the imaging scans, which may have blurred the link between atherosclerosis and CRP, says Wang. Future studies should clarify how best to combine the information from CRP tests, imaging studies, and knowledge of traditional risk factors such as high blood pressure, cholesterol and smoking.


###
Co-authors include Martin G. Larson, Sc.D.; Daniel Levy, M.D.; Emelia J. Benjamin, M.D., Sc.M.; Michelle J. Kupka, M.A.; Warren J. Manning, M.D.; Melvin E. Clouse, M.D.; Ralph B. D’Agostino, Ph.D.; Peter W.F. Wilson, M.D.; and Christopher J. O’Donnell, M.D., M.P.H.

This study was funded in part by the National Institutes of Health.

CONTACT: For journal copies only,
please call: (214) 706-1396
For other information, call:
Carole Bullock: (214) 706-1279
Bridgette McNeill: (214) 706-1135

Carole Bullock | EurekAlert!

More articles from Health and Medicine:

nachricht Custom-tailored strategy against glioblastomas
26.09.2016 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New leukemia treatment offers hope
23.09.2016 | King Abdullah University of Science and Technology

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First-Ever 3D Printed Excavator Project Advances Large-Scale Additive Manufacturing R&D

Heavy construction machinery is the focus of Oak Ridge National Laboratory’s latest advance in additive manufacturing research. With industry partners and university students, ORNL researchers are designing and producing the world’s first 3D printed excavator, a prototype that will leverage large-scale AM technologies and explore the feasibility of printing with metal alloys.

Increasing the size and speed of metal-based 3D printing techniques, using low-cost alloys like steel and aluminum, could create new industrial applications...

Im Focus: New welding process joins dissimilar sheets better

Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of light metals.
Scientists at the University of Stuttgart have now developed two new process variants that will considerably expand the areas of application for friction stir welding.
Technologie-Lizenz-Büro (TLB) GmbH supports the University of Stuttgart in patenting and marketing its innovations.

Friction stir welding is a still-young and thus often unfamiliar pressure welding process for joining flat components and semi-finished components made of...

Im Focus: First quantum photonic circuit with electrically driven light source

Optical quantum computers can revolutionize computer technology. A team of researchers led by scientists from Münster University and KIT now succeeded in putting a quantum optical experimental set-up onto a chip. In doing so, they have met one of the requirements for making it possible to use photonic circuits for optical quantum computers.

Optical quantum computers are what people are pinning their hopes on for tomorrow’s computer technology – whether for tap-proof data encryption, ultrafast...

Im Focus: OLED microdisplays in data glasses for improved human-machine interaction

The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.

“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...

Im Focus: Artificial Intelligence Helps in the Discovery of New Materials

With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.

Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Paper – Panacea Green Infrastructure?

30.09.2016 | Event News

HLF: From an experiment to an establishment

29.09.2016 | Event News

European Health Forum Gastein 2016 kicks off today

28.09.2016 | Event News

 
Latest News

First-Ever 3D Printed Excavator Project Advances Large-Scale Additive Manufacturing R&D

30.09.2016 | Materials Sciences

New Technique for Finding Weakness in Earth’s Crust

30.09.2016 | Earth Sciences

Cells migrate collectively by intermittent bursts of activity

30.09.2016 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>