A sort of biochemical scaffold for a compound that enables blood pressure to be low, heart bypass grafts to remain open and nerves to communicate has been identified by Medical College of Georgia researchers.
Dr. Richard C. Venema (left) and Dr. John D. Catravas have received American Heart Association and National Institutes of Health funding to study a biochemical scaffold they have discovered that helps keep blood pressure low and heart bypass grafts open.
A process called co-localization looks for the presence of two key proteins in the scaffold the researchers found; the antibody for heat shock protein 90 is labeled green and the one for sGC is labeled red. The yellow images show the proteins are found together in the living endothelial and smooth muscle cell. The left side shows the proteins in the endothelial cell and the right shows a smooth muscle cell.
Researchers say identifying the framework for how these and other very positive health benefits occur should help them find ways to augment the benefits and identify new treatments for cardiovascular disease, which may result when the support structure falls apart.
"Its a whole new ball game," Dr. John D. Catravas, director of the Vascular Biology Center, said of the findings which contradict previous understanding of how the compound, cyclic GMP, which also helps keep blood vessels open and enables penile erection, is ultimately produced.
Toni Baker | EurekAlert!
World first: Massive thrombosis removed during early pregnancy
20.07.2017 | Universitätsspital Bern
Therapy of preterm birth in sight?
19.07.2017 | Universitätsspital Bern
Physicists have developed a new technique that uses electrical voltages to control the electron spin on a chip. The newly-developed method provides protection from spin decay, meaning that the contained information can be maintained and transmitted over comparatively large distances, as has been demonstrated by a team from the University of Basel’s Department of Physics and the Swiss Nanoscience Institute. The results have been published in Physical Review X.
For several years, researchers have been trying to use the spin of an electron to store and transmit information. The spin of each electron is always coupled...
What is the mass of a proton? Scientists from Germany and Japan successfully did an important step towards the most exact knowledge of this fundamental constant. By means of precision measurements on a single proton, they could improve the precision by a factor of three and also correct the existing value.
To determine the mass of a single proton still more accurate – a group of physicists led by Klaus Blaum and Sven Sturm of the Max Planck Institute for Nuclear...
The research team of Prof. Dr. Oliver Einsle at the University of Freiburg's Institute of Biochemistry has long been exploring the functioning of nitrogenase....
A one trillion tonne iceberg - one of the biggest ever recorded -- has calved away from the Larsen C Ice Shelf in Antarctica, after a rift in the ice,...
Physics supports biology: Researchers from PTB have developed a model system to investigate friction phenomena with atomic precision
Friction: what you want from car brakes, otherwise rather a nuisance. In any case, it is useful to know as precisely as possible how friction phenomena arise –...
21.07.2017 | Event News
19.07.2017 | Event News
12.07.2017 | Event News
21.07.2017 | Earth Sciences
21.07.2017 | Power and Electrical Engineering
21.07.2017 | Physics and Astronomy