Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Gene therapy may increase cancer cure rates, medical physicists show

14.08.2002


An innovative combination of two medical procedures-gene therapy and radiation therapy--can increase cancer cure rates by significant amounts compared to the cure rates offered by conventional radiation therapy alone, a Virginia Commonwealth University (VCU) team has concluded. The researchers presented their results last month in Montreal at the annual conference of the American Association of Physicists in Medicine.



Known as genetic radiotherapy, the combined treatment can potentially increase cancer cure rates by up to 70% over present therapies that exclusively use radiation therapy, the researchers say. The combined technique is currently evolving from laboratory studies to human clinical trials.

In genetic radiotherapy, cancer cells are infected with a virus that makes tumor cells more sensitive to--and more easily destroyed by--radiation such as x-rays. At last month’s medical physics meeting, the VCU researchers presented a quantitative model predicting the increase in cancer cure rates with genetic radiotherapy.


"Our model incorporates human patient data from large radiotherapy clinical trials as well as experimental genetic therapy data from laboratory work," says Dr. Paul Keall, an assistant professor in VCU’s radiation oncology department.

To calculate the projected cure rates, the group considers the fraction of tumor cells that are genetically modified, or "transduced," by the injected virus. They also consider the sensitivity of the genetically transformed cells to radiation.

With present laboratory technology, the researchers predict an increase in cure rate of 15% when genetic radiotherapy is used instead of conventional radiation treatments on non-genetically-altered cancer cells. Exploring an ideal situation in which all of the cancer cells are genetically modified, they find the technique can theoretically increase the cancer cure rate by as much as 70%. In their model, a "cure" means a lack of tumor recurrence at the site where the tumor was treated.

"Thus, our results indicate that genetic radiotherapy has the potential to significantly improve cancer cure rates compared to current radiotherapy practices," says Keall. "Needed now are carefully controlled studies to test our predictions."


###
Meeting paper: "Radiobiological Predictions for Genetically Radiosensitized Tumors," by Paul Keall, PhD Guido Lammering, MD, Theodore Chung, MD, and Rupert Schmidt-Ullrich, MD, all at Department of Radiation Oncology, Virginia Commonwealth University, Richmond, VA, USA, paper MO-E-517B-7, Monday, July 15, 2002, 44th Annual AAPM Meeting, Montreal, Quebec.

Ben Stein | EurekAlert!
Further information:
http://www.aip.org/

More articles from Health and Medicine:

nachricht A promising target for kidney fibrosis
21.04.2017 | Brigham and Women's Hospital

nachricht Stem cell transplants: activating signal paths may protect from graft-versus-host disease
20.04.2017 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

Im Focus: Quantum-physical Model System

Computer-assisted methods aid Heidelberg physicists in reproducing experiment with ultracold atoms

Two researchers at Heidelberg University have developed a model system that enables a better understanding of the processes in a quantum-physical experiment...

Im Focus: Glacier bacteria’s contribution to carbon cycling

Glaciers might seem rather inhospitable environments. However, they are home to a diverse and vibrant microbial community. It’s becoming increasingly clear that they play a bigger role in the carbon cycle than previously thought.

A new study, now published in the journal Nature Geoscience, shows how microbial communities in melting glaciers contribute to the Earth’s carbon cycle, a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

New quantum liquid crystals may play role in future of computers

21.04.2017 | Physics and Astronomy

A promising target for kidney fibrosis

21.04.2017 | Health and Medicine

Light rays from a supernova bent by the curvature of space-time around a galaxy

21.04.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>