Two articles in the latest issue of Critical Care reveal how intensive care therapy may be beneficial in the short but not in the long term. Being treated in intensive care units may help critically ill patients survive but the quality of life - if they survive - is often severely impaired. It is unclear whether this impairment is a complication of the illness or a complication of therapy.
Many intensive care doctors believe the battle has been won once a patient leaves the intensive care unit, however Gordon Rubenfeld from the University of Washington in Seattle suggests that it is important to focus intensive care treatment on improving the long-term health of those who survive. Rubenfeld shows that doctors may face a conflict in deciding on treatments that are best at saving lives and those that give the best quality of life to those patients who survive. He stresses that more research is needed to make these decisions with confidence.
An example of research into how well or badly patients fare after they have left the intensive care unit is the study by Dale Rublee and colleagues. It examines the long-term effects of treating patients with sepsis with the drug antithrombin III. Antithrombin III affects the blood`s clotting mechanism and is a potential treatment for sepsis, a critical condition characterised by a combination of problems with the clotting mechanism and an inflammation throughout the body, which can lead to multiple organ failure and death.
Gordon Fletcher | alfa
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Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.
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