Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UCSD Study Shows Increased Transmission Of Drug-Resistant HIV Infection

08.08.2002


An increase in the transmission rate of drug-resistant human immunodeficiency virus (HIV), now affecting as many as one in five newly infected persons, has been discovered by researchers at the University of California, San Diego (UCSD) School of Medicine.



In a five-year, multi-center study of more than 300 patients in 10 North American cities, the investigators found that the transmission rate of drug-resistant HIV had more than doubled, resulting in impaired patient-response once anti-retroviral therapy was provided. The results are published in the August 8, 2002 issue of the New England Journal of Medicine.

According to lead author Susan Little, M.D., UCSD assistant professor of medicine, and senior author Douglas Richman, M.D., UCSD professor of medicine, resistance was noted in persons on single-drug therapy as well as those receiving potent multi-drug treatment.


"This points to the importance of routine drug-resistance tests for newly infected patients so that the most effective first-line treatment program can be initiated," said Richman, who is director of the UCSD AIDS Research Institute and the Research Center for AIDS and HIV Infection at the Veterans Affairs (VA) San Diego Health Care System.

Although past studies had estimated the transmission of drug-resistant HIV at 1 to 11 percent of newly infected patients, the new findings show the prevalence of viral mutations associated with resistance increased from 8.0 percent between 1995-98 to 22.7 percent during 1999-2000.

From May 1995 through June 2000, 377 individuals with primary HIV infection who had not yet received treatment were recruited for the study. Study subjects were predominantly non-Hispanic white men whose risk factor for HIV infection was unprotected sex with men, a group in which HIV drug resistance appears to be most prevalent, the researchers said.

Pre-treatment blood samples were analyzed to determine clinical resistance to 15 currently approved HIV drugs. In addition, the blood samples were analyzed for resistance to multi-drug regimens.

Response to treatment was then measured in 202 of the patients. Investigators looked at the length of time to viral suppression and/or the time to virologic failure, when treatment was no longer effective. Although viral suppression was demonstrated by week 24 of therapy in all but one patient, the median time to suppression was 56 days for those without the drug-resistant strain and 88 days for those with the drug-resistant form of the virus. The time to virologic failure was significantly shorter among those with drug-resistance.

In research results presented by Richman in December 2001 at the American Society for Microbiology, it was noted that more than three-quarters of HIV patients with a measurable viral load who are receiving care in the United States carry strains of the virus that are resistant to drug therapy.

In the current New England Journal of Medicine article, Little, Richman and their team said that "increases in the prevalence of drug-resistant virus among patients with established HIV infection may be associated with more frequent transmission of drug-resistant virus to newly infected persons in their community."

The authors also noted that "in both the developed and developing worlds, the treatment strategies for patients newly infected with HIV should take into account the prevalence of transmitted drug resistance."

The study was funded by the National Institutes of Health. In addition to Little and Richman, authors were Sarah Holte, Ph.D., Fred Hutchinson Cancer Research Center, and Ann C. Collier, M.D., University of Washington; Jean-Pierre Routy, M.D., McGill University Health Center, Montreal; Eric S. Daar, M.D., UCLA Medical Center; Marty Markowitz, M.D., Aaron Diamond AIDS Research Center, New York; Richard A. Koup, M.D., Vaccine Research Center, National Institutes of Health; John W. Mellors, M.D., University of Pittsburgh School of Medicine; Elizabeth Connick, M.D., University of Colorado Health Sciences Center; Brian Conway, M.D., University of British Columbia, Vancouver; Michael Kilby, M.D., University of Alabama, Birmingham; and Jeannette M. Whitcomb, Ph.D., and Nicholas S. Hellmann, M.D., ViroLogic, South San Francisco.


Media Contact:
Sue Pondrom
619-543-6164
spondrom@ucsd.edu

Sue Pondrom | EurekAlert!
Further information:
http://health.ucsd.edu/news

More articles from Health and Medicine:

nachricht Hot cars can hit deadly temperatures in as little as one hour
24.05.2018 | Arizona State University

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

In focus: Climate adapted plants

25.05.2018 | Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

 
Latest News

In focus: Climate adapted plants

25.05.2018 | Event News

Flow probes from the 3D printer

25.05.2018 | Machine Engineering

Less is more? Gene switch for healthy aging found

25.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>