Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

UCSD Study Shows Increased Transmission Of Drug-Resistant HIV Infection

08.08.2002


An increase in the transmission rate of drug-resistant human immunodeficiency virus (HIV), now affecting as many as one in five newly infected persons, has been discovered by researchers at the University of California, San Diego (UCSD) School of Medicine.



In a five-year, multi-center study of more than 300 patients in 10 North American cities, the investigators found that the transmission rate of drug-resistant HIV had more than doubled, resulting in impaired patient-response once anti-retroviral therapy was provided. The results are published in the August 8, 2002 issue of the New England Journal of Medicine.

According to lead author Susan Little, M.D., UCSD assistant professor of medicine, and senior author Douglas Richman, M.D., UCSD professor of medicine, resistance was noted in persons on single-drug therapy as well as those receiving potent multi-drug treatment.


"This points to the importance of routine drug-resistance tests for newly infected patients so that the most effective first-line treatment program can be initiated," said Richman, who is director of the UCSD AIDS Research Institute and the Research Center for AIDS and HIV Infection at the Veterans Affairs (VA) San Diego Health Care System.

Although past studies had estimated the transmission of drug-resistant HIV at 1 to 11 percent of newly infected patients, the new findings show the prevalence of viral mutations associated with resistance increased from 8.0 percent between 1995-98 to 22.7 percent during 1999-2000.

From May 1995 through June 2000, 377 individuals with primary HIV infection who had not yet received treatment were recruited for the study. Study subjects were predominantly non-Hispanic white men whose risk factor for HIV infection was unprotected sex with men, a group in which HIV drug resistance appears to be most prevalent, the researchers said.

Pre-treatment blood samples were analyzed to determine clinical resistance to 15 currently approved HIV drugs. In addition, the blood samples were analyzed for resistance to multi-drug regimens.

Response to treatment was then measured in 202 of the patients. Investigators looked at the length of time to viral suppression and/or the time to virologic failure, when treatment was no longer effective. Although viral suppression was demonstrated by week 24 of therapy in all but one patient, the median time to suppression was 56 days for those without the drug-resistant strain and 88 days for those with the drug-resistant form of the virus. The time to virologic failure was significantly shorter among those with drug-resistance.

In research results presented by Richman in December 2001 at the American Society for Microbiology, it was noted that more than three-quarters of HIV patients with a measurable viral load who are receiving care in the United States carry strains of the virus that are resistant to drug therapy.

In the current New England Journal of Medicine article, Little, Richman and their team said that "increases in the prevalence of drug-resistant virus among patients with established HIV infection may be associated with more frequent transmission of drug-resistant virus to newly infected persons in their community."

The authors also noted that "in both the developed and developing worlds, the treatment strategies for patients newly infected with HIV should take into account the prevalence of transmitted drug resistance."

The study was funded by the National Institutes of Health. In addition to Little and Richman, authors were Sarah Holte, Ph.D., Fred Hutchinson Cancer Research Center, and Ann C. Collier, M.D., University of Washington; Jean-Pierre Routy, M.D., McGill University Health Center, Montreal; Eric S. Daar, M.D., UCLA Medical Center; Marty Markowitz, M.D., Aaron Diamond AIDS Research Center, New York; Richard A. Koup, M.D., Vaccine Research Center, National Institutes of Health; John W. Mellors, M.D., University of Pittsburgh School of Medicine; Elizabeth Connick, M.D., University of Colorado Health Sciences Center; Brian Conway, M.D., University of British Columbia, Vancouver; Michael Kilby, M.D., University of Alabama, Birmingham; and Jeannette M. Whitcomb, Ph.D., and Nicholas S. Hellmann, M.D., ViroLogic, South San Francisco.


Media Contact:
Sue Pondrom
619-543-6164
spondrom@ucsd.edu

Sue Pondrom | EurekAlert!
Further information:
http://health.ucsd.edu/news

More articles from Health and Medicine:

nachricht Millions through license revenues
27.04.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Fighting drug resistant tuberculosis – InfectoGnostics meets MYCO-NET² partners in Peru

28.04.2017 | Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

 
Latest News

Wireless power can drive tiny electronic devices in the GI tract

28.04.2017 | Medical Engineering

Ice cave in Transylvania yields window into region's past

28.04.2017 | Earth Sciences

Nose2Brain – Better Therapy for Multiple Sclerosis

28.04.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>