Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Clemson researchers find bacteria fighter that does not promote bacterial resistance

02.08.2002


Health officials fear that lifesaving drugs can lose their effectiveness when overused. They are especially concerned about anti-microbial additives, found in everything from kitchen cleaners to face soaps, because the bacteria they try to kill are becoming resistant. Clemson University scientists have found a new bacteria fighter that does not promote bacterial resistance.

Food microbiologist Susan Barefoot and doctoral student researcher Priya Ratnam uncovered a new acne treatment that attacks bacteria unlike conventional commercial compounds. They have signed an agreement with a company to explore moving their find from lab to marketplace.

The team made their discovery as they searched for proteins that act as natural food preservatives. Called a bacteriocin, the protein is a tiny bit of antibiotic-like matter produced by the bacteria used to make Swiss cheese.



"It was really serendipity," Barefoot said. "We were looking for a bacteriocin from a close relative of the Swiss cheese bacteria. We found one, but it did not work as a new food preservative. After some discussion, we wondered if the bacteriocin would be effective against acne bacteria which are more distant relatives to the Swiss cheese bacteria."

The researchers have contracted with ImmuCell Corporation, a Portland, Maine -based biotechnology company, to jointly develop their work. ImmuCell produces innovative and proprietary products that improve animal health and productivity in the dairy and beef industry.

ImmuCell also is developing veterinary, environmental and skin-cleaning uses of the anti-microbial Nisin, another bacteriocin.

"ImmuCell is very excited about the potential for the anti-microbial Nisin to prevent acne, and together with Dr. Barefoot’s new anti-microbial, Jenseniin P, we have the potential to make a very potent product," said Richard T. Coughlin, the firm’s senior director of research and development. "Such a product could reduce the use of conventional antibiotics to treat non-life-threatening diseases and the rise in antibiotics resistant bacteria."

Through the Greenville Hospital System-Clemson University Biomedical Cooperative, Barefoot secured acne samples from dermatologists Eric Baker and Patricia Westmoreland. The Clemson researchers then isolated 150 acne bacteria to test the bacteriocin’s effectiveness.

"The acne bacteria was controlled in every single test," said Barefoot. "Every strain, every culture, two different testing methods -- all had the same results."

Scientific investigators do not expect 100-percent success rates, so Barefoot and her colleagues were somewhat incredulous and cautious about their findings.

"We must understand how it works and develop a method to produce enough bacteriocin for further testing," she said, adding that it is comparable to generating 55 gallons of material to collect a tiny straight pin of usable product.

The Clemson-based S.C. Agriculture and Forestry Research System and the Greenville Hospital System-Clemson University Biomedical Cooperative provide funding for the research.

Peter Kent | EurekAlert!
Further information:
http://www.clemson.edu/

More articles from Health and Medicine:

nachricht Investigators may unlock mystery of how staph cells dodge the body's immune system
22.09.2017 | Cedars-Sinai Medical Center

nachricht Monitoring the heart's mitochondria to predict cardiac arrest?
21.09.2017 | Boston Children's Hospital

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: The pyrenoid is a carbon-fixing liquid droplet

Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.

A warming planet

Im Focus: Highly precise wiring in the Cerebral Cortex

Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.

The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...

Im Focus: Tiny lasers from a gallery of whispers

New technique promises tunable laser devices

Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...

Im Focus: Ultrafast snapshots of relaxing electrons in solids

Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!

When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...

Im Focus: Quantum Sensors Decipher Magnetic Ordering in a New Semiconducting Material

For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.

Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

“Lasers in Composites Symposium” in Aachen – from Science to Application

19.09.2017 | Event News

I-ESA 2018 – Call for Papers

12.09.2017 | Event News

EMBO at Basel Life, a new conference on current and emerging life science research

06.09.2017 | Event News

 
Latest News

Rainbow colors reveal cell history: Uncovering β-cell heterogeneity

22.09.2017 | Life Sciences

Penn first in world to treat patient with new radiation technology

22.09.2017 | Medical Engineering

Calculating quietness

22.09.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>