Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Clemson researchers find bacteria fighter that does not promote bacterial resistance

02.08.2002


Health officials fear that lifesaving drugs can lose their effectiveness when overused. They are especially concerned about anti-microbial additives, found in everything from kitchen cleaners to face soaps, because the bacteria they try to kill are becoming resistant. Clemson University scientists have found a new bacteria fighter that does not promote bacterial resistance.

Food microbiologist Susan Barefoot and doctoral student researcher Priya Ratnam uncovered a new acne treatment that attacks bacteria unlike conventional commercial compounds. They have signed an agreement with a company to explore moving their find from lab to marketplace.

The team made their discovery as they searched for proteins that act as natural food preservatives. Called a bacteriocin, the protein is a tiny bit of antibiotic-like matter produced by the bacteria used to make Swiss cheese.



"It was really serendipity," Barefoot said. "We were looking for a bacteriocin from a close relative of the Swiss cheese bacteria. We found one, but it did not work as a new food preservative. After some discussion, we wondered if the bacteriocin would be effective against acne bacteria which are more distant relatives to the Swiss cheese bacteria."

The researchers have contracted with ImmuCell Corporation, a Portland, Maine -based biotechnology company, to jointly develop their work. ImmuCell produces innovative and proprietary products that improve animal health and productivity in the dairy and beef industry.

ImmuCell also is developing veterinary, environmental and skin-cleaning uses of the anti-microbial Nisin, another bacteriocin.

"ImmuCell is very excited about the potential for the anti-microbial Nisin to prevent acne, and together with Dr. Barefoot’s new anti-microbial, Jenseniin P, we have the potential to make a very potent product," said Richard T. Coughlin, the firm’s senior director of research and development. "Such a product could reduce the use of conventional antibiotics to treat non-life-threatening diseases and the rise in antibiotics resistant bacteria."

Through the Greenville Hospital System-Clemson University Biomedical Cooperative, Barefoot secured acne samples from dermatologists Eric Baker and Patricia Westmoreland. The Clemson researchers then isolated 150 acne bacteria to test the bacteriocin’s effectiveness.

"The acne bacteria was controlled in every single test," said Barefoot. "Every strain, every culture, two different testing methods -- all had the same results."

Scientific investigators do not expect 100-percent success rates, so Barefoot and her colleagues were somewhat incredulous and cautious about their findings.

"We must understand how it works and develop a method to produce enough bacteriocin for further testing," she said, adding that it is comparable to generating 55 gallons of material to collect a tiny straight pin of usable product.

The Clemson-based S.C. Agriculture and Forestry Research System and the Greenville Hospital System-Clemson University Biomedical Cooperative provide funding for the research.

Peter Kent | EurekAlert!
Further information:
http://www.clemson.edu/

More articles from Health and Medicine:

nachricht Finnish research group discovers a new immune system regulator
23.02.2018 | University of Turku

nachricht Minimising risks of transplants
22.02.2018 | Friedrich-Alexander-Universität Erlangen-Nürnberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Attoseconds break into atomic interior

A newly developed laser technology has enabled physicists in the Laboratory for Attosecond Physics (jointly run by LMU Munich and the Max Planck Institute of Quantum Optics) to generate attosecond bursts of high-energy photons of unprecedented intensity. This has made it possible to observe the interaction of multiple photons in a single such pulse with electrons in the inner orbital shell of an atom.

In order to observe the ultrafast electron motion in the inner shells of atoms with short light pulses, the pulses must not only be ultrashort, but very...

Im Focus: Good vibrations feel the force

A group of researchers led by Andrea Cavalleri at the Max Planck Institute for Structure and Dynamics of Matter (MPSD) in Hamburg has demonstrated a new method enabling precise measurements of the interatomic forces that hold crystalline solids together. The paper Probing the Interatomic Potential of Solids by Strong-Field Nonlinear Phononics, published online in Nature, explains how a terahertz-frequency laser pulse can drive very large deformations of the crystal.

By measuring the highly unusual atomic trajectories under extreme electromagnetic transients, the MPSD group could reconstruct how rigid the atomic bonds are...

Im Focus: Developing reliable quantum computers

International research team makes important step on the path to solving certification problems

Quantum computers may one day solve algorithmic problems which even the biggest supercomputers today can’t manage. But how do you test a quantum computer to...

Im Focus: In best circles: First integrated circuit from self-assembled polymer

For the first time, a team of researchers at the Max-Planck Institute (MPI) for Polymer Research in Mainz, Germany, has succeeded in making an integrated circuit (IC) from just a monolayer of a semiconducting polymer via a bottom-up, self-assembly approach.

In the self-assembly process, the semiconducting polymer arranges itself into an ordered monolayer in a transistor. The transistors are binary switches used...

Im Focus: Demonstration of a single molecule piezoelectric effect

Breakthrough provides a new concept of the design of molecular motors, sensors and electricity generators at nanoscale

Researchers from the Institute of Organic Chemistry and Biochemistry of the CAS (IOCB Prague), Institute of Physics of the CAS (IP CAS) and Palacký University...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

2nd International Conference on High Temperature Shape Memory Alloys (HTSMAs)

15.02.2018 | Event News

Aachen DC Grid Summit 2018

13.02.2018 | Event News

How Global Climate Policy Can Learn from the Energy Transition

12.02.2018 | Event News

 
Latest News

Basque researchers turn light upside down

23.02.2018 | Physics and Astronomy

Finnish research group discovers a new immune system regulator

23.02.2018 | Health and Medicine

Attoseconds break into atomic interior

23.02.2018 | Physics and Astronomy

VideoLinks
Science & Research
Overview of more VideoLinks >>>