Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Fluoxetine: antidepressant and a possible new drug for the treatment of obesity

30.07.2002


Genetically fattened Zucker fa/fa rats
© University of the Basque Country


The Department of Nutrition and Bromatology of the Faculty of Pharmacy of Gasteiz, University of the Basque Country, is studying the action mechanism of fluoxetine in genetically fattened rats (Zucker fa/fa). Due to fluoxetine, those rats eat 50 % less. Therefore, the bodies put on less weight and the size of different fat tissues is reduced.
Antidepressants of the type of fluoxetine reduce appetite. More exactly, fluoxetine affects on neuropeptides that regulate appetite. Hence, it is believed that fluoxetine can be used to treat obesity.

After studying the action-mechanism of fluoxetine it has been observed that it reduces the quantity of Y neuropeptide. That peptide is orexigen, it causes appetite. The fluoxetine does hinders the trasport of that peptide, and so appetite is reduced.


That result has lead the scientists of the faculty of pharmacy to study the effect of fluoxetine on melanocortins. Melanocortins are important neuropeptides that control how many food is consumed. Now they are studying the changes that may occur in the operative system of melanocortins, both in MC4-R melanocortin receptors and in a-MSH (alfa melanocyte stimulating hormones) .

Hunger and neuropeptides

Appetite is a feeling that is created in the hypothalamus and its regulation is a complex process that depends on the regulation of neuropeptides, neurotransmitters and several hormones. In that process two types of neuropeptides must be taken into account: orexigens or appetite stimulants and anorexigens or reducers of appetite.

Some of the well-known orexigens are Y neuropeptide, some opioid peptides, endogenous cannabinoid, etc. Among anorexigens CRF (corticotropin releasing factor), CART (cocaine and amphetamine related transcript), melanocortin, galanin and cytokines. All those neuropeptides have effect on the hypothalamus and their interaction causes hunger and satiety.

It is believed that those neuropeptides could be the responsible of disorders such as obesity, anorexia nervosa and bulimia. Nowadays there is no appropriate drug to treat those disorders and some of the cures that have been used are very dangerous and harmful for the health, for example amphetamines. According to the result of this research, who knows if fluoxetine, apart from being an antidepressant, may become a secure drug to treat obesity.

Garazi Andonegi | alfa
Further information:
http://www.basqueresearch.com/berria_irakurri.asp?Gelaxka=1&Berri_Kod=90&hizk=I
http://www.elhuyar.com

More articles from Health and Medicine:

nachricht Hot cars can hit deadly temperatures in as little as one hour
24.05.2018 | Arizona State University

nachricht 3D images of cancer cells in the body: Medical physicists from Halle present new method
16.05.2018 | Martin-Luther-Universität Halle-Wittenberg

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Powerful IT security for the car of the future – research alliance develops new approaches

The more electronics steer, accelerate and brake cars, the more important it is to protect them against cyber-attacks. That is why 15 partners from industry and academia will work together over the next three years on new approaches to IT security in self-driving cars. The joint project goes by the name Security For Connected, Autonomous Cars (SecForCARs) and has funding of €7.2 million from the German Federal Ministry of Education and Research. Infineon is leading the project.

Vehicles already offer diverse communication interfaces and more and more automated functions, such as distance and lane-keeping assist systems. At the same...

Im Focus: Molecular switch will facilitate the development of pioneering electro-optical devices

A research team led by physicists at the Technical University of Munich (TUM) has developed molecular nanoswitches that can be toggled between two structurally different states using an applied voltage. They can serve as the basis for a pioneering class of devices that could replace silicon-based components with organic molecules.

The development of new electronic technologies drives the incessant reduction of functional component sizes. In the context of an international collaborative...

Im Focus: LZH showcases laser material processing of tomorrow at the LASYS 2018

At the LASYS 2018, from June 5th to 7th, the Laser Zentrum Hannover e.V. (LZH) will be showcasing processes for the laser material processing of tomorrow in hall 4 at stand 4E75. With blown bomb shells the LZH will present first results of a research project on civil security.

At this year's LASYS, the LZH will exhibit light-based processes such as cutting, welding, ablation and structuring as well as additive manufacturing for...

Im Focus: Self-illuminating pixels for a new display generation

There are videos on the internet that can make one marvel at technology. For example, a smartphone is casually bent around the arm or a thin-film display is rolled in all directions and with almost every diameter. From the user's point of view, this looks fantastic. From a professional point of view, however, the question arises: Is that already possible?

At Display Week 2018, scientists from the Fraunhofer Institute for Applied Polymer Research IAP will be demonstrating today’s technological possibilities and...

Im Focus: Explanation for puzzling quantum oscillations has been found

So-called quantum many-body scars allow quantum systems to stay out of equilibrium much longer, explaining experiment | Study published in Nature Physics

Recently, researchers from Harvard and MIT succeeded in trapping a record 53 atoms and individually controlling their quantum state, realizing what is called a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

VideoLinks
Industry & Economy
Event News

In focus: Climate adapted plants

25.05.2018 | Event News

Save the date: Forum European Neuroscience – 07-11 July 2018 in Berlin, Germany

02.05.2018 | Event News

Invitation to the upcoming "Current Topics in Bioinformatics: Big Data in Genomics and Medicine"

13.04.2018 | Event News

 
Latest News

In focus: Climate adapted plants

25.05.2018 | Event News

Flow probes from the 3D printer

25.05.2018 | Machine Engineering

Less is more? Gene switch for healthy aging found

25.05.2018 | Life Sciences

VideoLinks
Science & Research
Overview of more VideoLinks >>>