Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

CWRU scientists demystify protein at root of arthritis

25.07.2002


Researchers at Case Western Reserve University have discovered kinks in aggrecan, a widely studied protein at the submolecular root of arthritis, a finding that brings scientists closer toward new drugs and other interventions to prevent or alleviate the disease.

"Aggrecan acts to organize and densely pack sugar molecules that give cartilage its resilience," said Steven Eppell, an assistant professor of biomedical engineering and director of the Nanoscale Orthopedic Biomaterials Laboratory at CWRU. "Our research shows that aggrecan is sharply bent in specific places and more flexible in other regions, and that the kinked areas may be more susceptible to the enzymes that degrade cartilage in osteoarthritis."

Eppell worked with Brian A. Todd and Jayan Rammohan, graduate students in the CWRU department of biomedical engineering, using funding from the National Institute for Arthritis and Musculoskeletal Research. The researchers examined the protein structure using an atomic force microscope in the Center for Cardiovascular Biomaterials at CWRU. Using sophisticated image processing, the team mapped images of aggrecan onto the human genome and discovered that the kinks in their images lined up with places where aggrecan gets degraded in osteoarthritis. The result provides a link between aggrecan’s structure and its function in health and disease.

"Clarifying the functions of more than 30,000 proteins that make up the proteome is a major challenge in the wake of the human genome project," Eppell said. "Studying human proteins and discovering how they interact inside their microscopic three dimensional world is a path leading scientists closer to linking a disease with its genetic characteristics. Trailblazing these paths requires us to investigate these proteins, one at a time, to learn how they interact inside their own three-dimensional world and in the body."

According to the National Institutes of Health, osteoarthritis is the most common type of arthritis, especially among older people. The disease causes joint pain and limited movement because the surface layer of cartilage breaks down and wears away and allows bones under the cartilage to rub together, causing pain, swelling and loss of motion of the joint. Currently there is no well-accepted theory for what causes this disease.

"We are working vigorously to link the biological and mechanical properties of cartilage with its molecular structure," Eppell said. "Ultimately, we are in search of clues that lead to intelligent drug design and other interventions to prevent or alleviate arthritis."

Marci E. Hersh | EurekAlert

More articles from Health and Medicine:

nachricht Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University

nachricht Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

Im Focus: Mimicking nature's cellular architectures via 3-D printing

Research offers new level of control over the structure of 3-D printed materials

Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...

Im Focus: Three Magnetic States for Each Hole

Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".

Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

Stingless bees have their nests protected by soldiers

24.02.2017 | Life Sciences

New risk factors for anxiety disorders

24.02.2017 | Life Sciences

MWC 2017: 5G Capital Berlin

24.02.2017 | Trade Fair News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>