Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Turning on hormone tap could aid osteoporosis fight

17.07.2008
A potential new drug that ‘opens the taps’ for the release of useful hormones could stimulate new bone growth – and may eventually bring relief to osteoporosis sufferers.

The exciting potential of so-called 'negative allosteric modulators' will be put under the microscope at a special symposium at The Federation of European Pharmacological Societies (EPHAR) 2008 Congress at The University of Manchester, UK, yesterday.

European pharmacologists meeting in Manchester will present work that focuses on the stimulation of parathyroids – tiny glands located above the thyroids that control the release of the parathyroid (PTH) hormone into the bloodstream.

When the concentration of calcium is too low in the blood’s plasma, PTH is released and acts on various tissues to increase the level of calcium in the blood. This calcium then activates the calcium sensing receptor on the parathyroid cell, which then reduces PTH release.

The first POSITIVE allosteric modulator was recently introduced into clinical practice for treating patients displaying high levels of PTH in the plasma – such as those with chronic kidney disease on dialysis and those displaying hypercalcaemia with parathyroid cancer. It mimics the effect of calcium on the receptor and so reduces PTH release.

But now attention is switching to NEGATIVE allosteric modulators, which have been shown in pre-clinical trials to block the effect of calcium on the parathyroid cell and thus increase the release of PTH in the serum.

“Daily administration of a negative allosteric modulator of the calcium sensing receptor should promote a sustained increase of PTH in such a way that it will stimulate new bone formation,” said symposium organiser Martial Ruat, a neuropharmacologist at the government-funded Centre National de la Recherche Scientifique in France.

“Now clinical trials will have to demonstrate the effectiveness and suitability of negative allosteric modulators for treating osteoporosis in humans.”

While pharmacologists are excited and encouraged by results so far, Dr Ruat says it will be at least another eight to 10 years before negative allosteric modulators are passed for use in patients “Osteoporosis is a complex disease and the timescale might be rather long,” says Dr Ruat, who is himself carrying out research to learn more about the potential benefits of both negative and positive allosteric modulators.

He added: “The calcium sensing receptor is also found in the kidney, the intestine, in some vascular and bone cells and also in the brain. We still need to identify the roles of this receptor in these tissues before being able to specify novel applications of these drugs.”

Negative and positive allosteric modulators are also being studied by European pharmacologists with a view to identifying the functions of calcium sensing receptors in the control of blood pressure.

Aeron Haworth | alfa
Further information:
http://www.manchester.ac.uk

More articles from Health and Medicine:

nachricht Biofilm discovery suggests new way to prevent dangerous infections
23.05.2017 | University of Texas at Austin

nachricht Another reason to exercise: Burning bone fat -- a key to better bone health
19.05.2017 | University of North Carolina Health Care

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can the immune system be boosted against Staphylococcus aureus by delivery of messenger RNA?

Staphylococcus aureus is a feared pathogen (MRSA, multi-resistant S. aureus) due to frequent resistances against many antibiotics, especially in hospital infections. Researchers at the Paul-Ehrlich-Institut have identified immunological processes that prevent a successful immune response directed against the pathogenic agent. The delivery of bacterial proteins with RNA adjuvant or messenger RNA (mRNA) into immune cells allows the re-direction of the immune response towards an active defense against S. aureus. This could be of significant importance for the development of an effective vaccine. PLOS Pathogens has published these research results online on 25 May 2017.

Staphylococcus aureus (S. aureus) is a bacterium that colonizes by far more than half of the skin and the mucosa of adults, usually without causing infections....

Im Focus: A quantum walk of photons

Physicists from the University of Würzburg are capable of generating identical looking single light particles at the push of a button. Two new studies now demonstrate the potential this method holds.

The quantum computer has fuelled the imagination of scientists for decades: It is based on fundamentally different phenomena than a conventional computer....

Im Focus: Turmoil in sluggish electrons’ existence

An international team of physicists has monitored the scattering behaviour of electrons in a non-conducting material in real-time. Their insights could be beneficial for radiotherapy.

We can refer to electrons in non-conducting materials as ‘sluggish’. Typically, they remain fixed in a location, deep inside an atomic composite. It is hence...

Im Focus: Wafer-thin Magnetic Materials Developed for Future Quantum Technologies

Two-dimensional magnetic structures are regarded as a promising material for new types of data storage, since the magnetic properties of individual molecular building blocks can be investigated and modified. For the first time, researchers have now produced a wafer-thin ferrimagnet, in which molecules with different magnetic centers arrange themselves on a gold surface to form a checkerboard pattern. Scientists at the Swiss Nanoscience Institute at the University of Basel and the Paul Scherrer Institute published their findings in the journal Nature Communications.

Ferrimagnets are composed of two centers which are magnetized at different strengths and point in opposing directions. Two-dimensional, quasi-flat ferrimagnets...

Im Focus: World's thinnest hologram paves path to new 3-D world

Nano-hologram paves way for integration of 3-D holography into everyday electronics

An Australian-Chinese research team has created the world's thinnest hologram, paving the way towards the integration of 3D holography into everyday...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Marine Conservation: IASS Contributes to UN Ocean Conference in New York on 5-9 June

24.05.2017 | Event News

AWK Aachen Machine Tool Colloquium 2017: Internet of Production for Agile Enterprises

23.05.2017 | Event News

Dortmund MST Conference presents Individualized Healthcare Solutions with micro and nanotechnology

22.05.2017 | Event News

 
Latest News

How herpesviruses win the footrace against the immune system

26.05.2017 | Life Sciences

Water forms 'spine of hydration' around DNA, group finds

26.05.2017 | Life Sciences

First Juno science results supported by University of Leicester's Jupiter 'forecast'

26.05.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>