Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Researchers of the Université Libre de Bruxelles (ULB) elucidate the early mechanism of cardiovascular specification

03.07.2008
Important clinical and pharmaceutical implications.

The mature heart is composed by different cell types, including contractile cardiac cells, vascular cells, smooth muscle cells as well as pacemaker cells. During embryonic development as well as during embryonic stem cell differentiation, the different cardiovascular cell types arise from the differentiation of multipotent cardiovascular progenitors. The mechanism that promotes multipotent cardiovascular progenitor specification from undifferentiated mesoderm cell remains largely unknown.

Now, researchers from the Université Libre de Bruxelles lead by Cédric Blanpain (IRIBHM, Faculty of Medicine), shed new light into the early mechanism that governs cardiovascular specification. This research is published in July 3 issue of Cell Stem Cell.

Researchers uncover the key molecular switch that specifies undifferentiated mesodermal cells to become cardiovascular progenitors. The authors of this study found that a protein called Mesp1 acts a master regulator of multipotent cardiovascular progenitor specification. They showed that a very transient expression of a Mesp1, increase by more than 500% the differentiation of pluripotent stem cells into cardiac and vascular cells, which represent the greatest promotion of cardiovascular differentiation induced by a single factor. “When we look at the Mesp1 stimulated cells under the microscope, it was just amazing! It was looking like all cells became cardiac cells, and were spontaneously beating everywhere in the dish”, comments Antoine Bondue, the first author of the paper.

To better understand the molecular mechanism by which Mesp1 promotes cardiovascular specification, researchers from ULB used a genome-wide analysis to identify which genes are regulated by Mesp1. They found that Mesp1 directly activated many previously identified key genes responsible for cardiovascular differentiation. “Mesp1 allows the coordinate expression of all these important cardiac genes at the right place and at the right time”, comments Cédric Blanpain, the principal investigator of this study. Mesp1 also directly repressed genes promoting the acquisition of other possible cell identity during this developmental stage, ensuring the specificity in the promotion of cardiovascular cell identity induced by Mesp1. These results demonstrate that Mesp1 acts as a key regulatory switch during cardiovascular specification, residing at the top of the hierarchy of the gene network responsible for cardiovascular cell fate determination.

This new and exciting study from Cédric Blanpain Lab has also important clinical and pharmaceutical implications. Cardiovascular diseases are the primary cause of death in western countries. The method presented in this study may be used in the future to increase the source of cardiovascular cells for cellular therapy in humans, but also to generate the large amount of cardiovascular cells required for toxicology and drug screenings.

Nancy Dath | alfa
Further information:
http://www.ulb.ac.be

More articles from Health and Medicine:

nachricht Cystic fibrosis alters the structure of mucus in airways
28.06.2017 | University of Iowa Health Care

nachricht Mice provide insight into genetics of autism spectrum disorders
28.06.2017 | University of California - Davis

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Can we see monkeys from space? Emerging technologies to map biodiversity

An international team of scientists has proposed a new multi-disciplinary approach in which an array of new technologies will allow us to map biodiversity and the risks that wildlife is facing at the scale of whole landscapes. The findings are published in Nature Ecology and Evolution. This international research is led by the Kunming Institute of Zoology from China, University of East Anglia, University of Leicester and the Leibniz Institute for Zoo and Wildlife Research.

Using a combination of satellite and ground data, the team proposes that it is now possible to map biodiversity with an accuracy that has not been previously...

Im Focus: Climate satellite: Tracking methane with robust laser technology

Heatwaves in the Arctic, longer periods of vegetation in Europe, severe floods in West Africa – starting in 2021, scientists want to explore the emissions of the greenhouse gas methane with the German-French satellite MERLIN. This is made possible by a new robust laser system of the Fraunhofer Institute for Laser Technology ILT in Aachen, which achieves unprecedented measurement accuracy.

Methane is primarily the result of the decomposition of organic matter. The gas has a 25 times greater warming potential than carbon dioxide, but is not as...

Im Focus: How protons move through a fuel cell

Hydrogen is regarded as the energy source of the future: It is produced with solar power and can be used to generate heat and electricity in fuel cells. Empa researchers have now succeeded in decoding the movement of hydrogen ions in crystals – a key step towards more efficient energy conversion in the hydrogen industry of tomorrow.

As charge carriers, electrons and ions play the leading role in electrochemical energy storage devices and converters such as batteries and fuel cells. Proton...

Im Focus: A unique data centre for cosmological simulations

Scientists from the Excellence Cluster Universe at the Ludwig-Maximilians-Universität Munich have establised "Cosmowebportal", a unique data centre for cosmological simulations located at the Leibniz Supercomputing Centre (LRZ) of the Bavarian Academy of Sciences. The complete results of a series of large hydrodynamical cosmological simulations are available, with data volumes typically exceeding several hundred terabytes. Scientists worldwide can interactively explore these complex simulations via a web interface and directly access the results.

With current telescopes, scientists can observe our Universe’s galaxies and galaxy clusters and their distribution along an invisible cosmic web. From the...

Im Focus: Scientists develop molecular thermometer for contactless measurement using infrared light

Temperature measurements possible even on the smallest scale / Molecular ruby for use in material sciences, biology, and medicine

Chemists at Johannes Gutenberg University Mainz (JGU) in cooperation with researchers of the German Federal Institute for Materials Research and Testing (BAM)...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Plants are networkers

19.06.2017 | Event News

Digital Survival Training for Executives

13.06.2017 | Event News

Global Learning Council Summit 2017

13.06.2017 | Event News

 
Latest News

Supersensitive through quantum entanglement

28.06.2017 | Physics and Astronomy

X-ray photoelectron spectroscopy under real ambient pressure conditions

28.06.2017 | Physics and Astronomy

Mice provide insight into genetics of autism spectrum disorders

28.06.2017 | Health and Medicine

VideoLinks
B2B-VideoLinks
More VideoLinks >>>