Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

10 percent of healthy people in study had injury from 'silent strokes'

30.06.2008
American Heart Association rapid access journal report

A recent study found that about 10 percent of the apparently healthy middle-aged participants with no symptoms of stroke were injured from "silent strokes," researchers report in Stroke: Journal of the American Heart Association.

Silent cerebral infarction (SCI), or "silent stroke," is a brain injury likely caused by a blood clot interrupting blood flow in the brain. It's a risk factor for future strokes and a sign of progressive brain damage that may result in long-term dementia.

"The findings reinforce the need for early detection and treatment of cardiovascular risk factors in midlife," said Sudha Seshadri, M.D., co-author of the study and associate professor of neurology at Boston University School of Medicine. "This is especially true since SCIs have been associated with an increased risk of incident stroke and cognitive impairment."

Researchers evaluated magnetic resonance imaging (MRI) from about 2,000 people, average age 62, who are part of the Framingham Offspring Study (children of participants in the original Framingham Heart Study). The offspring have undergone clinical examinations every four to eight years.

Among patients who displayed no symptoms of stroke, 10.7 percent had SCIs on routine brain MRI, researchers said. Previous estimates of SCIs ranged from 5.8 percent to 17.7 percent depending on age, ethnicity and other issues. Of those in the study with SCIs, 84 percent had a single lesion.

The study is the first to correlate the total score of the Framingham Stroke Risk Profile to prevalence of SCI. The risk profile estimates the 10-year probability of having a stroke. The factors in the profile are age, systolic blood pressure, antihypertensive therapy, diabetes mellitus, cigarette smoking, cardiovascular disease, left ventricular hypertrophy and atrial fibrillation (AF).

All the components of the Framingham Stroke Risk Profile were positively associated with an increased prevalence of SCI. For the first time, researchers found a significant correlation between AF and silent cerebral infarction. AF is the most common form of heart arrhythmia, or irregular heartbeat in people older than 65.

"In our data, AF increased the risk of prevalent SCI more than two-fold," Seshadri said. Hypertension and systolic blood pressure were also associated with an increased prevalence of SCI.

Risk factors for stroke are also risk factors for AF. Hypertension and other factors that make it more likely individuals will experience AF also predispose those people to clinical stroke and probably to SCI. AF, therefore, may be a simultaneous outcome rather than a cause of SCI, researchers said.

The observational data could not indicate if screening for and appropriately treating AF would reduce the population burden of silent stroke, researchers said.

The study also found that high systolic blood pressure, hypertension and elevated levels of blood homocysteine, a sulfur-containing amino acid found in the blood, were other risk factors commonly associated with stroke that also raised participants' chances of having SCI. Hypertension consistently has been implicated as a risk factor of SCI. Neither age nor gender significantly changed the effect of any of the risk factors on SCI.

Researchers' ability to generalize findings for other ethnic groups is limited because participants in the Framingham study are mostly of European descent.

"The significant relationship between hypertension, elevated serum homocysteine, carotid artery disease and prevalent SCI underscores the importance of current guidelines for the early diagnosis and prevention of hypertension and atherosclerosis and their risk factors," Seshadri said.

Bridgette McNeill | EurekAlert!
Further information:
http://www.heart.org

More articles from Health and Medicine:

nachricht Cholesterol-lowering drugs may fight infectious disease
22.08.2017 | Duke University

nachricht Once invincible superbug squashed by 'superteam' of antibiotics
22.08.2017 | University at Buffalo

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Fizzy soda water could be key to clean manufacture of flat wonder material: Graphene

Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.

As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

What the world's tiniest 'monster truck' reveals

23.08.2017 | Life Sciences

Treating arthritis with algae

23.08.2017 | Life Sciences

Witnessing turbulent motion in the atmosphere of a distant star

23.08.2017 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>