A research group from the department of medicine at the Universidad Autónoma de Madrid (UAM) has studied the causes and consequences of the cell suicide of renal cells.
Diabetes slowly destroys the kidney up to the point where the renal function has to be taken on by dialysis (artificial kidney) or a transplanted kidney. It is the leading cause of end stage renal failure that requires dialysis. The destruction of the kidney comes from the loss of its cells, which recent studies have demonstrated to be caused by apoptosis, a process that, for cells, involves death by suicide.
Cells suicide when their environment does not “please” them, when their surroundings feel hostile or stressful. The Spanish team managed by Alberto Ortiz, professor of the department of medicine of the UAM based at the Jiménez Díaz-Capio foundation, has spent years studying the causes and the consequences of kidney cell suicide, specializing in “psycho-cellulology”.
The team analyzed the genes related with apoptosis as a part of a European collaborative effort (European Renal Biopsy Bank) that studies the expression pattern of genes found in patients suffering from diabetic nephropathy. The affected kidneys exhibited an abnormal expression of 112 genes that regulate the cell suicide. Among these genes, the Spanish team identified a protein of the Tumour Necrosis Factor (TNF) family, called TRAIL, as the key to the cell suicide in diabetes affected kidneys.
In these kidneys, large quantities of TRAIL can be found that surprisingly do not come from the increased glucose levels that define the disease, but from the inflammation that accompanies the renal damage. Inflammation and higher glucose levels favour renal damage; the inflammation raises the TRAIL levels while the hyperglycaemia generates a stressful environment that, in the presence of TRAIL, leads to cell suicide.
The role played by inflammation in the cell suicide that leads to renal damage suggests that the treatment of diabetic nephropathies requires a multiple attack to control the glucose levels while also acting on the renal inflammation and lethal proteins like TRAIL.
This study is part of the efforts carried out by the Red de Investigación Renal (RedInRen), financed by the Carlos III institute, to expose the mechanisms of renal lesions and develop new treatments for renal diseases. The results from this study have been published on-line in the Journal of the American Society of Nephrology (J Am Soc Nephrol. 2008, [Epub ahead of print]), the most representative journal for Nephrology and Urology.
Oficina de Cultura Científica | alfa
Advanced analysis of brain structure shape may track progression to Alzheimer's disease
26.10.2016 | Massachusetts General Hospital
Indian roadside refuse fires produce toxic rainbow
26.10.2016 | Duke University
Ultrafast lasers have introduced new possibilities in engraving ultrafine structures, and scientists are now also investigating how to use them to etch microstructures into thin glass. There are possible applications in analytics (lab on a chip) and especially in electronics and the consumer sector, where great interest has been shown.
This new method was born of a surprising phenomenon: irradiating glass in a particular way with an ultrafast laser has the effect of making the glass up to a...
Terahertz excitation of selected crystal vibrations leads to an effective magnetic field that drives coherent spin motion
Controlling functional properties by light is one of the grand goals in modern condensed matter physics and materials science. A new study now demonstrates how...
Researchers from the Institute for Quantum Computing (IQC) at the University of Waterloo led the development of a new extensible wiring technique capable of controlling superconducting quantum bits, representing a significant step towards to the realization of a scalable quantum computer.
"The quantum socket is a wiring method that uses three-dimensional wires based on spring-loaded pins to address individual qubits," said Jeremy Béjanin, a PhD...
In a paper in Scientific Reports, a research team at Worcester Polytechnic Institute describes a novel light-activated phenomenon that could become the basis for applications as diverse as microscopic robotic grippers and more efficient solar cells.
A research team at Worcester Polytechnic Institute (WPI) has developed a revolutionary, light-activated semiconductor nanocomposite material that can be used...
By forcefully embedding two silicon atoms in a diamond matrix, Sandia researchers have demonstrated for the first time on a single chip all the components needed to create a quantum bridge to link quantum computers together.
"People have already built small quantum computers," says Sandia researcher Ryan Camacho. "Maybe the first useful one won't be a single giant quantum computer...
14.10.2016 | Event News
14.10.2016 | Event News
12.10.2016 | Event News
27.10.2016 | Materials Sciences
27.10.2016 | Physics and Astronomy
27.10.2016 | Life Sciences