Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Precancerous Lesions Of The Endometrium: Uterus And Fertility Can Be Preserved

03.06.2008
Until recently, the traditional approach to precancerous lesions of the endometrium was based on curettage (scraping), a blind and aggressive diagnostic procedure that didn’t single out focal from extended lesions.

Lacking more precise information, clinical doctors used to turn to hysterectomy, or uterus removal, which precluded future pregnancies to affected women. Hysteroscopy changed this approach, allowing to identify lesions that require a more conservative management, like with precancerous lesions of uterine cervix (or bowel).

The effectiveness of such a conservative approach - very useful in young women who plan future pregnancies – was proved by a five-years investigation carried out at the Hysteroscopy Service of the Department of Obstetrics and Gynecology at the Institute of Child Health Burlo Garofolo (ICHBG) in Trieste, Italy, directed by Professor Secondo Guaschino.

In the trial, conservative resectoscopic treatment was offered to 21 fertile women with atypical polyps (the earliest mark of endometrium cancer) wishing to preserve their uterus. Patients gave their consent to the study after being informed that international guidelines recommend hysterectomy for their pathology. Furthermore, they were told about the importance of regular hysteroscopic follow-up, since only direct observation of uterine cavity could assure their health. After the hysteroscopic polyp removal, women were subsequently monitored on a regular basis: twice a year for the first 24 months, and once a year in the next 36 months. After 5 years of follow–up, all patients were disease free. The study is actually in press in the American Journal of Obstetrics & Gynecology.

“This approach to the pathology – points out Federica Scrimin, head of the Hysteroscopy Service at Burlo Garofolo – is innovative in that it allows a moderately invasive intervention, preserving the uterus. Resectoscopic polypectomy is a simple intervention; it can be performed under day hospital conditions owing to the new instruments. Although the study is small, these results are promising and encouraged us to start a larger multicentric trial to evaluate the long-term efficacy and prognosis of hysteroscopic resection and coagulation of the base of endometrial polyps with focal atypia in fertile women.”

“Our interest in conservative management of endometrial lesions – says Professor Secondo Guaschino, Head of the Department of Obstetrics and Gynecology at ICHBG – dates back to 2000, when we offered hysteroscopic resection to 16 postmenopausal patients with atypical endometrial polyps who had cardiovascular disorders and were considered at high risk after preoperative anesthesiologic evaluation.

After 5 years of follow-up 13 patients were disease free. That study was published in the American Journal of Obstetrics & Gynecology. Now, we are fully aware that this conservative and little invasive method is the right one for women who wish to preserve their fertility and ability to have children. Our approach is in line with Burlo Garofolo’s, an Institute always caring for women’s health and well being”.

Cristina Serra | alfa
Further information:
http://www.burlo.trieste.it

More articles from Health and Medicine:

nachricht A better way to measure the stiffness of cancer cells
01.03.2017 | Duke University

nachricht Humans have three times more brown body fat
01.03.2017 | Technische Universität München

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Researchers Imitate Molecular Crowding in Cells

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to simulate these confined natural conditions in artificial vesicles for the first time. As reported in the academic journal Small, the results are offering better insight into the development of nanoreactors and artificial organelles.

Enzymes behave differently in a test tube compared with the molecular scrum of a living cell. Chemists from the University of Basel have now been able to...

Im Focus: Safe glide at total engine failure with ELA-inside

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.

On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...

Im Focus: Breakthrough with a chain of gold atoms

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

In the field of nanoscience, an international team of physicists with participants from Konstanz has achieved a breakthrough in understanding heat transport

Im Focus: DNA repair: a new letter in the cell alphabet

Results reveal how discoveries may be hidden in scientific “blind spots”

Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...

Im Focus: Dresdner scientists print tomorrow’s world

The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.

The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Booth and panel discussion – The Lindau Nobel Laureate Meetings at the AAAS 2017 Annual Meeting

13.02.2017 | Event News

Complex Loading versus Hidden Reserves

10.02.2017 | Event News

International Conference on Crystal Growth in Freiburg

09.02.2017 | Event News

 
Latest News

A better way to measure the stiffness of cancer cells

01.03.2017 | Health and Medicine

Exploring the mysteries of supercooled water

01.03.2017 | Physics and Astronomy

Research team of the HAW Hamburg reanimated ancestral microbe from the depth of the earth

01.03.2017 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>