Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Bone repair using patient's stem cells comes closer

26.05.2008
Enzyme induces adult stem cells to grow bone

Hitherto it has been difficult to induce adult human stem cells to produce bone, e.g. in order to repair bone tissue. Researchers at the University of Twente have shown that if the enzyme PKA is previously activated in the stem cells in the lab, following implantation this results in substantial bone formation. This opens up new ways of repairing bone tissue using cell material from the patient. The researchers are publishing their work in the Proceedings of the National Academy of Sciences (PNAS).

In animals, ‘adult’ mesenchymal stem cells have already been used successfully to grow fresh bone. Bone formation using human adult stem cells, e.g. from bone marrow, has been less successful, which has hitherto limited the alternatives hospitals can offer for repairing damaged tissue other than spontaneous healing. Activating the PKA enzyme prior to implantation, however, produces a dramatic improvement in ‘in vivo’ bone growth. The cells can be observed maturing into bone cells already in the lab; once sown on a carrier and implanted in a mouse, the bone grows well.

Encouraging the neighbours
The enzyme protein kinase A (PKA) is responsible for many processes in a cell. The messenger ‘cyclic AMP’ activates PKA: adding it to the stem cells ensures that they stimulate one another, the researchers think. Not only does cyclic AMP promote maturation into bone cells; the cells themselves also secrete various substances that stimulate bone growth. This may explain why mesenchymal stem cells treated with cyclic AMP form significantly more bone than those without the stimulus.

The advantage of administering a bone-growth-stimulating substance in advance is that it can be removed just before implantation. Experiments to date have mainly used high concentrations of a bone-growth-stimulating hormone, e.g. incorporated in the carrier on which the cells are ‘sown’. In the new approach not only are the hormone concentrations lower, they also more closely resemble the cocktail of hormones normally involved in bone growth.

This is the second time in a short space of time that the researchers, led by Dr Jan de Boer, have published in PNAS: earlier this month they published an article on a major breakthrough in the use of embryonic stem cells to grow bone. Both methods are promising when it comes to repairing bone tissue in future using cells from the patient’s own body. Compact bioreactors will be developed to grow cells quickly into tissue that can be used in the operating theatre.

The research was carried out at the Tissue Regeneration Department of the University of Twente’s Institute for Biomechanical Technology (BMTI). The researchers collaborated with fellow scientists at UMC Utrecht and the Erasmus Medical Center in Rotterdam.

Wiebe van der Veen | alfa
Further information:
http://www.utwente.nl/en

More articles from Health and Medicine:

nachricht Penn studies find promise for innovations in liquid biopsies
30.03.2017 | University of Pennsylvania School of Medicine

nachricht 'On-off switch' brings researchers a step closer to potential HIV vaccine
30.03.2017 | University of Nebraska-Lincoln

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: A Challenging European Research Project to Develop New Tiny Microscopes

The Institute of Semiconductor Technology and the Institute of Physical and Theoretical Chemistry, both members of the Laboratory for Emerging Nanometrology (LENA), at Technische Universität Braunschweig are partners in a new European research project entitled ChipScope, which aims to develop a completely new and extremely small optical microscope capable of observing the interior of living cells in real time. A consortium of 7 partners from 5 countries will tackle this issue with very ambitious objectives during a four-year research program.

To demonstrate the usefulness of this new scientific tool, at the end of the project the developed chip-sized microscope will be used to observe in real-time...

Im Focus: Giant Magnetic Fields in the Universe

Astronomers from Bonn and Tautenburg in Thuringia (Germany) used the 100-m radio telescope at Effelsberg to observe several galaxy clusters. At the edges of these large accumulations of dark matter, stellar systems (galaxies), hot gas, and charged particles, they found magnetic fields that are exceptionally ordered over distances of many million light years. This makes them the most extended magnetic fields in the universe known so far.

The results will be published on March 22 in the journal „Astronomy & Astrophysics“.

Galaxy clusters are the largest gravitationally bound structures in the universe. With a typical extent of about 10 million light years, i.e. 100 times the...

Im Focus: Tracing down linear ubiquitination

Researchers at the Goethe University Frankfurt, together with partners from the University of Tübingen in Germany and Queen Mary University as well as Francis Crick Institute from London (UK) have developed a novel technology to decipher the secret ubiquitin code.

Ubiquitin is a small protein that can be linked to other cellular proteins, thereby controlling and modulating their functions. The attachment occurs in many...

Im Focus: Perovskite edges can be tuned for optoelectronic performance

Layered 2D material improves efficiency for solar cells and LEDs

In the eternal search for next generation high-efficiency solar cells and LEDs, scientists at Los Alamos National Laboratory and their partners are creating...

Im Focus: Polymer-coated silicon nanosheets as alternative to graphene: A perfect team for nanoelectronics

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are less stable. Now researchers at the Technical University of Munich (TUM) have, for the first time ever, produced a composite material combining silicon nanosheets and a polymer that is both UV-resistant and easy to process. This brings the scientists a significant step closer to industrial applications like flexible displays and photosensors.

Silicon nanosheets are thin, two-dimensional layers with exceptional optoelectronic properties very similar to those of graphene. Albeit, the nanosheets are...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

International Land Use Symposium ILUS 2017: Call for Abstracts and Registration open

20.03.2017 | Event News

CONNECT 2017: International congress on connective tissue

14.03.2017 | Event News

ICTM Conference: Turbine Construction between Big Data and Additive Manufacturing

07.03.2017 | Event News

 
Latest News

'On-off switch' brings researchers a step closer to potential HIV vaccine

30.03.2017 | Health and Medicine

Penn studies find promise for innovations in liquid biopsies

30.03.2017 | Health and Medicine

An LED-based device for imaging radiation induced skin damage

30.03.2017 | Medical Engineering

VideoLinks
B2B-VideoLinks
More VideoLinks >>>