Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cancer vaccine targets immortalisation factor in cancer cell

04.07.2002


A new vaccination strategy targeting telomerase, one of the enzymes responsible for making cancer cells immortal, has been developed at the Norwegian Radium Hospital. "The vaccine might offer a means of stabilising cancer", states Professor Gustav Gaudernack at a press conference at the 18th UICC International Cancer Congress in Oslo this week.



A new vaccination strategy targeting telomerase, one of the enzymes responsible for making cancer cells immortal, has been tested by Professor Trond Buanes on patients with pancreatic cancer at Ullevaal University Hospital. The vaccine was developed by a research team headed by Professor Gustav Gaudernack at the Norwegian Radium Hospital.

Initiated in September 2000, the ongoing study comprises 31 patients with inoperable pancreatic cancer who have been treated with the vaccine. With the optimal dose, the majority of the patients have experienced an immune response to the vaccine. There is a trend for these patients to live longer than those who failed to respond, and for the patients who received a higher dose to live longer than those who received the lower dose. Gaudernack warns that since there was little evidence of tumour reduction, this is not a cure but rather a means of stabilising the cancer.


The vaccine has been designed to encourage the immune system to respond to telomerase produced by cancer cells. Found in virtually all types of cancer, this target is responsible for giving cancer cells an unlimited capacity to divide. The immunologists’ aim is to stimulate the patient’s own immune system to recognise this protein and destroy the cancer cells while leaving the healthy cells alone. There are still some questions related to the long-term safety of the vaccine.

Gaudernack emphasises the need to verify these results by controlled studies on larger groups of patients.

These research efforts are supported by the Norwegian Cancer Society and the Norwegian biotech company GemVax.


Contacts:
Researcher Gustav Gaudernack, Norwegian Radium Hospital
Tel +47 22 93 40 00

18th UICC International Cancer Congress,
Press Office: Hanna Hånes
Tel +47 901 56 040, e-mail: haanes@oslo2002.org

Hanna Hånes | EurekAlert!
Further information:
http://www.kreft.no/

More articles from Health and Medicine:

nachricht New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia

nachricht New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Exotic quantum states made from light: Physicists create optical “wells” for a super-photon

Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.

Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...

Im Focus: Circular RNA linked to brain function

For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.

While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...

Im Focus: RAVAN CubeSat measures Earth's outgoing energy

An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.

The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...

Im Focus: Scientists shine new light on the “other high temperature superconductor”

A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.

Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...

Im Focus: Scientists improve forecast of increasing hazard on Ecuadorian volcano

Researchers from the University of Miami (UM) Rosenstiel School of Marine and Atmospheric Science, the Italian Space Agency (ASI), and the Instituto Geofisico--Escuela Politecnica Nacional (IGEPN) of Ecuador, showed an increasing volcanic danger on Cotopaxi in Ecuador using a powerful technique known as Interferometric Synthetic Aperture Radar (InSAR).

The Andes region in which Cotopaxi volcano is located is known to contain some of the world's most serious volcanic hazard. A mid- to large-size eruption has...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Call for Papers – ICNFT 2018, 5th International Conference on New Forming Technology

16.08.2017 | Event News

Sustainability is the business model of tomorrow

04.08.2017 | Event News

Clash of Realities 2017: Registration now open. International Conference at TH Köln

26.07.2017 | Event News

 
Latest News

New thruster design increases efficiency for future spaceflight

16.08.2017 | Physics and Astronomy

Transporting spin: A graphene and boron nitride heterostructure creates large spin signals

16.08.2017 | Materials Sciences

A new method for the 3-D printing of living tissues

16.08.2017 | Interdisciplinary Research

VideoLinks
B2B-VideoLinks
More VideoLinks >>>