Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

Cancer vaccine targets immortalisation factor in cancer cell

04.07.2002


A new vaccination strategy targeting telomerase, one of the enzymes responsible for making cancer cells immortal, has been developed at the Norwegian Radium Hospital. "The vaccine might offer a means of stabilising cancer", states Professor Gustav Gaudernack at a press conference at the 18th UICC International Cancer Congress in Oslo this week.



A new vaccination strategy targeting telomerase, one of the enzymes responsible for making cancer cells immortal, has been tested by Professor Trond Buanes on patients with pancreatic cancer at Ullevaal University Hospital. The vaccine was developed by a research team headed by Professor Gustav Gaudernack at the Norwegian Radium Hospital.

Initiated in September 2000, the ongoing study comprises 31 patients with inoperable pancreatic cancer who have been treated with the vaccine. With the optimal dose, the majority of the patients have experienced an immune response to the vaccine. There is a trend for these patients to live longer than those who failed to respond, and for the patients who received a higher dose to live longer than those who received the lower dose. Gaudernack warns that since there was little evidence of tumour reduction, this is not a cure but rather a means of stabilising the cancer.


The vaccine has been designed to encourage the immune system to respond to telomerase produced by cancer cells. Found in virtually all types of cancer, this target is responsible for giving cancer cells an unlimited capacity to divide. The immunologists’ aim is to stimulate the patient’s own immune system to recognise this protein and destroy the cancer cells while leaving the healthy cells alone. There are still some questions related to the long-term safety of the vaccine.

Gaudernack emphasises the need to verify these results by controlled studies on larger groups of patients.

These research efforts are supported by the Norwegian Cancer Society and the Norwegian biotech company GemVax.


Contacts:
Researcher Gustav Gaudernack, Norwegian Radium Hospital
Tel +47 22 93 40 00

18th UICC International Cancer Congress,
Press Office: Hanna Hånes
Tel +47 901 56 040, e-mail: haanes@oslo2002.org

Hanna Hånes | EurekAlert!
Further information:
http://www.kreft.no/

More articles from Health and Medicine:

nachricht Routing gene therapy directly into the brain
07.12.2017 | Boston Children's Hospital

nachricht New Hope for Cancer Therapies: Targeted Monitoring may help Improve Tumor Treatment
01.12.2017 | Berliner Institut für Gesundheitsforschung / Berlin Institute of Health (BIH)

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Scientists channel graphene to understand filtration and ion transport into cells

Tiny pores at a cell's entryway act as miniature bouncers, letting in some electrically charged atoms--ions--but blocking others. Operating as exquisitely sensitive filters, these "ion channels" play a critical role in biological functions such as muscle contraction and the firing of brain cells.

To rapidly transport the right ions through the cell membrane, the tiny channels rely on a complex interplay between the ions and surrounding molecules,...

Im Focus: Towards data storage at the single molecule level

The miniaturization of the current technology of storage media is hindered by fundamental limits of quantum mechanics. A new approach consists in using so-called spin-crossover molecules as the smallest possible storage unit. Similar to normal hard drives, these special molecules can save information via their magnetic state. A research team from Kiel University has now managed to successfully place a new class of spin-crossover molecules onto a surface and to improve the molecule’s storage capacity. The storage density of conventional hard drives could therefore theoretically be increased by more than one hundred fold. The study has been published in the scientific journal Nano Letters.

Over the past few years, the building blocks of storage media have gotten ever smaller. But further miniaturization of the current technology is hindered by...

Im Focus: Successful Mechanical Testing of Nanowires

With innovative experiments, researchers at the Helmholtz-Zentrums Geesthacht and the Technical University Hamburg unravel why tiny metallic structures are extremely strong

Light-weight and simultaneously strong – porous metallic nanomaterials promise interesting applications as, for instance, for future aeroplanes with enhanced...

Im Focus: Virtual Reality for Bacteria

An interdisciplinary group of researchers interfaced individual bacteria with a computer to build a hybrid bio-digital circuit - Study published in Nature Communications

Scientists at the Institute of Science and Technology Austria (IST Austria) have managed to control the behavior of individual bacteria by connecting them to a...

Im Focus: A space-time sensor for light-matter interactions

Physicists in the Laboratory for Attosecond Physics (run jointly by LMU Munich and the Max Planck Institute for Quantum Optics) have developed an attosecond electron microscope that allows them to visualize the dispersion of light in time and space, and observe the motions of electrons in atoms.

The most basic of all physical interactions in nature is that between light and matter. This interaction takes place in attosecond times (i.e. billionths of a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

See, understand and experience the work of the future

11.12.2017 | Event News

Innovative strategies to tackle parasitic worms

08.12.2017 | Event News

AKL’18: The opportunities and challenges of digitalization in the laser industry

07.12.2017 | Event News

 
Latest News

PhoxTroT: Optical Interconnect Technologies Revolutionized Data Centers and HPC Systems

11.12.2017 | Information Technology

Large-scale battery storage system in field trial

11.12.2017 | Power and Electrical Engineering

See, understand and experience the work of the future

11.12.2017 | Event News

VideoLinks
B2B-VideoLinks
More VideoLinks >>>