In its latest round of awards, which brings the number of university research fellowships supported by the charity to 16, HOPE selected three projects that would benefit from PhD Studentships.
Professor David Lambert, Division of Pharmacology and Therapeutics, and Professor David Rowbotham, Department of Health Sciences, in collaboration with Drs Girolamo Calo and Remo Guerrini in Ferrara, Italy, are investigating the design and evaluation of new morphine-like analgesics with reduced side effects for long term use in cancer pain.
“Laboratory work has shown that this type of approach produces pain relief. We need to further refine the work to enable studies to be performed in patients. This will be a relatively long-term process (not within 3-5 years for example). However it offers a completely new approach to pain management. This particular project would not be possible without HOPE funding,” Professor Rowbotham said.
Dr Catrin Pritchard, Department of Biochemistry, is researching one of the major contributing factors in the development of human cancers and particularly colorectal cancer - the mutation of the BRAF proto-oncogene.
She explained the significance of the funding to her work: “Through the Hope Foundation fellowship we aim to utilize a technique called microarray to generate a “gene signature” for BRAF-induced cancers.
“Essentially this will provide us with an overview of all the gene expression changes that accompany the development of cancer following BRAF mutation in the gut and also following treatment with BRAF inhibitors.
“These studies are imperative as they will allow us to identify new effector genes involved in development of colorectal cancers, to track the efficacy of BRAF inhibition, and to identify if any resistance to the BRAF inhibitors is occurring.
“We are extremely grateful to receive funding from organizations like Hope Against Cancer, and really appreciate all the hard work that many people do to raise funds for our research.”
Dr Raffael Schaffrath, Department of Genetics, is analysing ovarian cancer at the molecular level to provide a means of improving the prevention, early diagnosis and treatment of patients or those who are at risk of developing the disease.
As a result of the HOPE funding, all three projects will now be able to appoint a PhD student dedicated to their research area. Dr Schaffrath expressed what that will mean to his project:
“Firstly, the HOPE project provides the funds for a talented young scientist who will receive expert training in a range of modern molecular and cellular technologies. He or she will be exposed to an exciting area of international cancer research and engaged in close interactions with other cancer researchers at the University of Leicester.
“Secondly, through HOPE, our research group as a whole will further develop its activities from basic science to biomedically relevant cancer research. So, we have a great chance to contribute further to cancer research conducted at the Department of Genetics, which is superbly equipped for all aspects of cellular and molecular biology, including genomics/proteomics facilities and state-of-the-art tissue culture and microscopy suites.
“I consider the HOPE project to be an excellent catalyst to enhance the research standards of our own group and to improve the reputation of the Department of Genetics, University of Leicester.”
This is the second round of PhD Studentships that Hope Against Cancer has funded. Lasting for three years, they enable PhD students to give more time to their research, as outgoing recipient of a Hope award, James Thorpe, explained: “In our group we are investigating whether chemicals from tea called polyphenols can prevent or delay prostate cancer.
“The funding that I have received from HOPE to maintain my research has allowed me to focus my efforts on cancer prevention. Prior to being funded, I was obliged to support my research by working 40 hours a week as a junior doctor. This limited the time available to concentrate on my research at a time when I was attempting to set up clinical trials.
“By being able to focus full time on cancer prevention experiments I have made much more progress than would otherwise have been possible. I have been able to extend the project into a third year. This will allow me to bring the work that I started to a conclusion and to write it up as a PhD. I am extremely grateful to HOPE for the support they gave to me personally and to cancer research in Leicestershire.”
Ather Mirza | alfa
Millions through license revenues
27.04.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn
New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM
More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.
Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...
Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.
"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...
The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.
Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...
The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...
Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.
Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...
28.04.2017 | Event News
20.04.2017 | Event News
18.04.2017 | Event News
28.04.2017 | Medical Engineering
28.04.2017 | Earth Sciences
28.04.2017 | Life Sciences