Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New scanner holds promise of better breast cancer detection

03.07.2002


A new high-resolution nuclear medicine imaging scanner specifically designed for breast exams has the potential to increase physicians’ ability to determine if a woman has breast cancer, and may be particularly useful for women with dense breasts. The results of this early study were reported in the July 2002 issue of the Journal of Nuclear Medicine, published by the Society of Nuclear Medicine.



When compared with scintimammographic images taken on a standard gamma camera, the new camera, called a high-resolution breast-specific gamma camera (HRBGC), was able to detect more (78%) malignancies than a standard gamma camera (68%). The sensitivity of breast cancer detected in lesions <1cm increased from 46.7% to 66.7% using the new camera. It also detected 3 lesions that were not visible with mammography; one of which did not appear on the standard camera. All three were in areas of dense breast tissue.

Scintimammography is a technique in which women are injected with the radiotracer 99mTc-sestamibi that is absorbed more by malignant tissue than normal tissue, resulting in an image that can be used to locate cancerous areas. Scintimammography has been shown in studies to detect breast cancer better than traditional mammography. Standard gamma cameras have some significant drawbacks, including registration and resolution issues, and the fact that they cannot acquire multiple views, making it difficult detect lesions <1cm. This preliminary study utilized a prototype breast-specific gamma camera that was designed to address these problems.


Fifty women with a total of 58 lesions that were either palpable, or which had shown up on a mammogram or sonogram even though they couldn’t be felt, were included in the study. After injection with the radiopharmaceutical, the women received consecutive scans; one with the conventional gamma camera, and then one with the prototype camera. All the lesions were ultimately either surgically or needle biopsied, so that findings were pathologically confirmed. Of the lesions, 30 (52%) were benign, and 28 (48%) were malignant. The study authors suggested that since the second, high-resolution scan was undertaken outside the limits of the tracer’s activity, future studies with proper dose-to-scan time-scanning might show even better results.

"This new type of camera ultimately may offer physicians a practical way to include scintimammography, with its superior ability to detect cancer, in their clinical practice as an adjunct to mammography," stated study author Rachel Brem, MD.

A commentary that accompanied the article noted that while current mammography is very good at detecting breast abnormalities it only predicts 50% of the time whether the abnormality is actually breast cancer. Scintimammography and the breast-specific camera may overcome the problem of differentiating benign from malignant abnormalities in addition to locating otherwise undetected cancers.



High-Resolution Scintimammography: A Pilot Study was written by Rachel F. Brem, MD of the Breast Imaging and Intervention Center, George Washington University Medical Center, Washington, DC; Joelle M. Schoonjans, MD, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Institutions, Baltimore, MD; Douglas A. Kieper, BS and Stan Majewski, PhD, Thomas Jefferson National Accelerator Facility, Newport News, Virginia; Steven Goodman, MD, PhD, Department of Oncology, Johns Hopkins Institutions, Baltimore, MD; and Cahid Civelek, MD, Department of Radiology and Radiological Science, Johns Hopkins Institutions. This article was supported by a grant from Dilon Technologies, Inc., and by DuPont Pharma, Inc. Dr. Brem is a consultant to and has stock options in Dilon Technologies, Inc.

Copies of the article and images related to the study are available to media upon request to Karen Lubieniecki at Karenlub@aol.com; (703) 683-0357. Copies of this and past issues of The Journal of Nuclear Medicine are available online at jnm.snmjournals.org. Print copies can be obtained at $15 per copy by contacting the SNM Service Center, Society of Nuclear Medicine, 1850 Samuel Morse Drive, Reston, VA 20190-5315; phone: (703) 326-1186; fax: (703) 708-9015; e-mail: servicecenter@snm.org. A yearly subscription to the journal is $170. A journal subscription is a member benefit of the Society of Nuclear Medicine.


Karen Lubieniecki | EurekAlert!

More articles from Health and Medicine:

nachricht Millions through license revenues
27.04.2017 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New High-Performance Center Translational Medical Engineering
26.04.2017 | Fraunhofer ITEM

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Making lightweight construction suitable for series production

More and more automobile companies are focusing on body parts made of carbon fiber reinforced plastics (CFRP). However, manufacturing and repair costs must be further reduced in order to make CFRP more economical in use. Together with the Volkswagen AG and five other partners in the project HolQueSt 3D, the Laser Zentrum Hannover e.V. (LZH) has developed laser processes for the automatic trimming, drilling and repair of three-dimensional components.

Automated manufacturing processes are the basis for ultimately establishing the series production of CFRP components. In the project HolQueSt 3D, the LZH has...

Im Focus: Wonder material? Novel nanotube structure strengthens thin films for flexible electronics

Reflecting the structure of composites found in nature and the ancient world, researchers at the University of Illinois at Urbana-Champaign have synthesized thin carbon nanotube (CNT) textiles that exhibit both high electrical conductivity and a level of toughness that is about fifty times higher than copper films, currently used in electronics.

"The structural robustness of thin metal films has significant importance for the reliable operation of smart skin and flexible electronics including...

Im Focus: Deep inside Galaxy M87

The nearby, giant radio galaxy M87 hosts a supermassive black hole (BH) and is well-known for its bright jet dominating the spectrum over ten orders of magnitude in frequency. Due to its proximity, jet prominence, and the large black hole mass, M87 is the best laboratory for investigating the formation, acceleration, and collimation of relativistic jets. A research team led by Silke Britzen from the Max Planck Institute for Radio Astronomy in Bonn, Germany, has found strong indication for turbulent processes connecting the accretion disk and the jet of that galaxy providing insights into the longstanding problem of the origin of astrophysical jets.

Supermassive black holes form some of the most enigmatic phenomena in astrophysics. Their enormous energy output is supposed to be generated by the...

Im Focus: A Quantum Low Pass for Photons

Physicists in Garching observe novel quantum effect that limits the number of emitted photons.

The probability to find a certain number of photons inside a laser pulse usually corresponds to a classical distribution of independent events, the so-called...

Im Focus: Microprocessors based on a layer of just three atoms

Microprocessors based on atomically thin materials hold the promise of the evolution of traditional processors as well as new applications in the field of flexible electronics. Now, a TU Wien research team led by Thomas Müller has made a breakthrough in this field as part of an ongoing research project.

Two-dimensional materials, or 2D materials for short, are extremely versatile, although – or often more precisely because – they are made up of just one or a...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Expert meeting “Health Business Connect” will connect international medical technology companies

20.04.2017 | Event News

Wenn der Computer das Gehirn austrickst

18.04.2017 | Event News

7th International Conference on Crystalline Silicon Photovoltaics in Freiburg on April 3-5, 2017

03.04.2017 | Event News

 
Latest News

Bare bones: Making bones transparent

27.04.2017 | Life Sciences

Study offers new theoretical approach to describing non-equilibrium phase transitions

27.04.2017 | Physics and Astronomy

From volcano's slope, NASA instrument looks sky high and to the future

27.04.2017 | Earth Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>