Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

New scanner holds promise of better breast cancer detection

03.07.2002


A new high-resolution nuclear medicine imaging scanner specifically designed for breast exams has the potential to increase physicians’ ability to determine if a woman has breast cancer, and may be particularly useful for women with dense breasts. The results of this early study were reported in the July 2002 issue of the Journal of Nuclear Medicine, published by the Society of Nuclear Medicine.



When compared with scintimammographic images taken on a standard gamma camera, the new camera, called a high-resolution breast-specific gamma camera (HRBGC), was able to detect more (78%) malignancies than a standard gamma camera (68%). The sensitivity of breast cancer detected in lesions <1cm increased from 46.7% to 66.7% using the new camera. It also detected 3 lesions that were not visible with mammography; one of which did not appear on the standard camera. All three were in areas of dense breast tissue.

Scintimammography is a technique in which women are injected with the radiotracer 99mTc-sestamibi that is absorbed more by malignant tissue than normal tissue, resulting in an image that can be used to locate cancerous areas. Scintimammography has been shown in studies to detect breast cancer better than traditional mammography. Standard gamma cameras have some significant drawbacks, including registration and resolution issues, and the fact that they cannot acquire multiple views, making it difficult detect lesions <1cm. This preliminary study utilized a prototype breast-specific gamma camera that was designed to address these problems.


Fifty women with a total of 58 lesions that were either palpable, or which had shown up on a mammogram or sonogram even though they couldn’t be felt, were included in the study. After injection with the radiopharmaceutical, the women received consecutive scans; one with the conventional gamma camera, and then one with the prototype camera. All the lesions were ultimately either surgically or needle biopsied, so that findings were pathologically confirmed. Of the lesions, 30 (52%) were benign, and 28 (48%) were malignant. The study authors suggested that since the second, high-resolution scan was undertaken outside the limits of the tracer’s activity, future studies with proper dose-to-scan time-scanning might show even better results.

"This new type of camera ultimately may offer physicians a practical way to include scintimammography, with its superior ability to detect cancer, in their clinical practice as an adjunct to mammography," stated study author Rachel Brem, MD.

A commentary that accompanied the article noted that while current mammography is very good at detecting breast abnormalities it only predicts 50% of the time whether the abnormality is actually breast cancer. Scintimammography and the breast-specific camera may overcome the problem of differentiating benign from malignant abnormalities in addition to locating otherwise undetected cancers.



High-Resolution Scintimammography: A Pilot Study was written by Rachel F. Brem, MD of the Breast Imaging and Intervention Center, George Washington University Medical Center, Washington, DC; Joelle M. Schoonjans, MD, Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Institutions, Baltimore, MD; Douglas A. Kieper, BS and Stan Majewski, PhD, Thomas Jefferson National Accelerator Facility, Newport News, Virginia; Steven Goodman, MD, PhD, Department of Oncology, Johns Hopkins Institutions, Baltimore, MD; and Cahid Civelek, MD, Department of Radiology and Radiological Science, Johns Hopkins Institutions. This article was supported by a grant from Dilon Technologies, Inc., and by DuPont Pharma, Inc. Dr. Brem is a consultant to and has stock options in Dilon Technologies, Inc.

Copies of the article and images related to the study are available to media upon request to Karen Lubieniecki at Karenlub@aol.com; (703) 683-0357. Copies of this and past issues of The Journal of Nuclear Medicine are available online at jnm.snmjournals.org. Print copies can be obtained at $15 per copy by contacting the SNM Service Center, Society of Nuclear Medicine, 1850 Samuel Morse Drive, Reston, VA 20190-5315; phone: (703) 326-1186; fax: (703) 708-9015; e-mail: servicecenter@snm.org. A yearly subscription to the journal is $170. A journal subscription is a member benefit of the Society of Nuclear Medicine.


Karen Lubieniecki | EurekAlert!

More articles from Health and Medicine:

nachricht Study suggests possible new target for treating and preventing Alzheimer's
02.12.2016 | Oregon Health & Science University

nachricht The first analysis of Ewing's sarcoma methyloma opens doors to new treatments
01.12.2016 | IDIBELL-Bellvitge Biomedical Research Institute

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: Novel silicon etching technique crafts 3-D gradient refractive index micro-optics

A multi-institutional research collaboration has created a novel approach for fabricating three-dimensional micro-optics through the shape-defined formation of porous silicon (PSi), with broad impacts in integrated optoelectronics, imaging, and photovoltaics.

Working with colleagues at Stanford and The Dow Chemical Company, researchers at the University of Illinois at Urbana-Champaign fabricated 3-D birefringent...

Im Focus: Quantum Particles Form Droplets

In experiments with magnetic atoms conducted at extremely low temperatures, scientists have demonstrated a unique phase of matter: The atoms form a new type of quantum liquid or quantum droplet state. These so called quantum droplets may preserve their form in absence of external confinement because of quantum effects. The joint team of experimental physicists from Innsbruck and theoretical physicists from Hannover report on their findings in the journal Physical Review X.

“Our Quantum droplets are in the gas phase but they still drop like a rock,” explains experimental physicist Francesca Ferlaino when talking about the...

Im Focus: MADMAX: Max Planck Institute for Physics takes up axion research

The Max Planck Institute for Physics (MPP) is opening up a new research field. A workshop from November 21 - 22, 2016 will mark the start of activities for an innovative axion experiment. Axions are still only purely hypothetical particles. Their detection could solve two fundamental problems in particle physics: What dark matter consists of and why it has not yet been possible to directly observe a CP violation for the strong interaction.

The “MADMAX” project is the MPP’s commitment to axion research. Axions are so far only a theoretical prediction and are difficult to detect: on the one hand,...

Im Focus: Molecules change shape when wet

Broadband rotational spectroscopy unravels structural reshaping of isolated molecules in the gas phase to accommodate water

In two recent publications in the Journal of Chemical Physics and in the Journal of Physical Chemistry Letters, researchers around Melanie Schnell from the Max...

Im Focus: Fraunhofer ISE Develops Highly Compact, High Frequency DC/DC Converter for Aviation

The efficiency of power electronic systems is not solely dependent on electrical efficiency but also on weight, for example, in mobile systems. When the weight of relevant components and devices in airplanes, for instance, is reduced, fuel savings can be achieved and correspondingly greenhouse gas emissions decreased. New materials and components based on gallium nitride (GaN) can help to reduce weight and increase the efficiency. With these new materials, power electronic switches can be operated at higher switching frequency, resulting in higher power density and lower material costs.

Researchers at the Fraunhofer Institute for Solar Energy Systems ISE together with partners have investigated how these materials can be used to make power...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

ICTM Conference 2017: Production technology for turbomachine manufacturing of the future

16.11.2016 | Event News

Innovation Day Laser Technology – Laser Additive Manufacturing

01.11.2016 | Event News

#IC2S2: When Social Science meets Computer Science - GESIS will host the IC2S2 conference 2017

14.10.2016 | Event News

 
Latest News

UTSA study describes new minimally invasive device to treat cancer and other illnesses

02.12.2016 | Medical Engineering

Plasma-zapping process could yield trans fat-free soybean oil product

02.12.2016 | Agricultural and Forestry Science

What do Netflix, Google and planetary systems have in common?

02.12.2016 | Physics and Astronomy

VideoLinks
B2B-VideoLinks
More VideoLinks >>>