Women who suffer repeated unexplained miscarriages can be helped to have babies if preimplantation genetic diagnosis (PGD) is carried out on their embryos before they are placed in the womb.
Ms Carmen Rubio told the European Society of Human Reproduction and Embryology annual conference in Vienna today (Monday 1 July) that her research showed that chromosomal abnormalities (aneuploidies) in the embryos were important causes of unexplained recurrent miscarriages (RM) and implantation failure (IF). She and her colleagues had achieved normal pregnancy rates and a decreased risk of miscarriage in women with these conditions by screening the embryos for chromosomal abnormalities during IVF and transferring only the normal embryos to the women’s wombs.
Ms Rubio, co-ordinator of the PGD programme at the Instituto Valenciano de Infertilidad, Valencia, Spain, said: "We know already that non-inherited abnormalities in the number of chromosomes is a common cause of miscarriage and that embryos which fail to implant successfully during IVF and ICSI often have these abnormalities as well. We wondered whether chromosomal abnormalities, produced while the male or female sex cells are being formed, or during the early development of the embryo, might be an important factor in women with RM or IF."
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