Forum for Science, Industry and Business

Sponsored by:     3M 
Search our Site:

 

PGD could save women from the agony of repeated miscarriages

01.07.2002


Women who suffer repeated unexplained miscarriages can be helped to have babies if preimplantation genetic diagnosis (PGD) is carried out on their embryos before they are placed in the womb.

Ms Carmen Rubio told the European Society of Human Reproduction and Embryology annual conference in Vienna today (Monday 1 July) that her research showed that chromosomal abnormalities (aneuploidies) in the embryos were important causes of unexplained recurrent miscarriages (RM) and implantation failure (IF). She and her colleagues had achieved normal pregnancy rates and a decreased risk of miscarriage in women with these conditions by screening the embryos for chromosomal abnormalities during IVF and transferring only the normal embryos to the women’s wombs.

Ms Rubio, co-ordinator of the PGD programme at the Instituto Valenciano de Infertilidad, Valencia, Spain, said: "We know already that non-inherited abnormalities in the number of chromosomes is a common cause of miscarriage and that embryos which fail to implant successfully during IVF and ICSI often have these abnormalities as well. We wondered whether chromosomal abnormalities, produced while the male or female sex cells are being formed, or during the early development of the embryo, might be an important factor in women with RM or IF."



The team carried out PGD in 71 RM couples where the woman had had two or more unexplained miscarriages, and in 42 IF couples who had had three or more unsuccessful IVF or ICSI attempts in the previous four years. A control group of 28 fertile women who were undergoing PGD for sex-linked diseases was added to the study.

The researchers found that the percentage of embryos with abnormal chromosomes was approximately a third higher in the RM and IF groups, compared with the control group. Ms Rubio said: "These differences were especially remarkable in embryos from women under 37 years old; these were twice as likely to be abnormal. This is significant because women under 37 are a better group for comparing the incidence of chromosomal abnormalities in embryos in RM and IF patients, because once a woman is over 37 her age becomes an additional risk factor for aneuploidies."

After transferring only the normal embryos to the women, the researchers achieved similar pregnancy rates in all three groups (34.3% in the RM group, 32.4% in the IF group and 29% in the control group), and the miscarriage rate was similar too (13%, 0% and 0% – 13% in the RM group representing a reduction from a high risk to a level similar to the estimated miscarriage rate in the general population of about 15%).

Ms Rubio said: "Our study shows that, in some couples suffering from repeated unexplained miscarriages or implantation failure, chromosomal abnormalities in the embryo can be the cause of the problem. High pregnancy rates and a decreased risk of further miscarriages can be achieved in these couples by using PGD to select only the normal embryos to be transferred into the uterus. PGD could also be used as a diagnostic tool to identify couples with an increased risk of producing embryos with chromosomal abnormalities and even couples whose embryos are all abnormal."

Further information:

Margaret Willson, information officerEmma Mason, information officer
Tel: +44 (0) 1536 772181Tel: +44 (0) 1376 563090
Fax: +44 (0) 1536 772191Fax: +44 (0) 1376 563272
Mobile: +44 (0) 7973 853347Mobile: +44 (0)7711 296986
Email: m.willson@mwcommunications.org.uk   Email: wordmason@aol.com

Press Office: (Sunday 30 June -Wednesday 3 July)

Margaret Willson, Emma Mason, Janet Blümli
Tel: +43 (0) 1 260 69 2010 or +43 (0) 1 260 69 2011
Fax: +43 (0) 1 260 69 2012

Emma Mason | EurekAlert!
Further information:
http://www.eshre.com/
http://conf.eshre.com/PDF/O-081.pdf

More articles from Health and Medicine:

nachricht Custom-tailored strategy against glioblastomas
26.09.2016 | Rheinische Friedrich-Wilhelms-Universität Bonn

nachricht New leukemia treatment offers hope
23.09.2016 | King Abdullah University of Science and Technology

All articles from Health and Medicine >>>

The most recent press releases about innovation >>>

Die letzten 5 Focus-News des innovations-reports im Überblick:

Im Focus: First quantum photonic circuit with electrically driven light source

Optical quantum computers can revolutionize computer technology. A team of researchers led by scientists from Münster University and KIT now succeeded in putting a quantum optical experimental set-up onto a chip. In doing so, they have met one of the requirements for making it possible to use photonic circuits for optical quantum computers.

Optical quantum computers are what people are pinning their hopes on for tomorrow’s computer technology – whether for tap-proof data encryption, ultrafast...

Im Focus: OLED microdisplays in data glasses for improved human-machine interaction

The Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP has been developing various applications for OLED microdisplays based on organic semiconductors. By integrating the capabilities of an image sensor directly into the microdisplay, eye movements can be recorded by the smart glasses and utilized for guidance and control functions, as one example. The new design will be debuted at Augmented World Expo Europe (AWE) in Berlin at Booth B25, October 18th – 19th.

“Augmented-reality” and “wearables” have become terms we encounter almost daily. Both can make daily life a little simpler and provide valuable assistance for...

Im Focus: Artificial Intelligence Helps in the Discovery of New Materials

With the help of artificial intelligence, chemists from the University of Basel in Switzerland have computed the characteristics of about two million crystals made up of four chemical elements. The researchers were able to identify 90 previously unknown thermodynamically stable crystals that can be regarded as new materials. They report on their findings in the scientific journal Physical Review Letters.

Elpasolite is a glassy, transparent, shiny and soft mineral with a cubic crystal structure. First discovered in El Paso County (Colorado, USA), it can also be...

Im Focus: Complex hardmetal tools out of the 3D printer

For the first time, Fraunhofer IKTS shows additively manufactured hardmetal tools at WorldPM 2016 in Hamburg. Mechanical, chemical as well as a high heat resistance and extreme hardness are required from tools that are used in mechanical and automotive engineering or in plastics and building materials industry. Researchers at the Fraunhofer Institute for Ceramic Technologies and Systems IKTS in Dresden managed the production of complex hardmetal tools via 3D printing in a quality that are in no way inferior to conventionally produced high-performance tools.

Fraunhofer IKTS counts decades of proven expertise in the development of hardmetals. To date, reliable cutting, drilling, pressing and stamping tools made of...

Im Focus: Launch of New Industry Working Group for Process Control in Laser Material Processing

At AKL’16, the International Laser Technology Congress held in May this year, interest in the topic of process control was greater than expected. Appropriately, the event was also used to launch the Industry Working Group for Process Control in Laser Material Processing. The group provides a forum for representatives from industry and research to initiate pre-competitive projects and discuss issues such as standards, potential cost savings and feasibility.

In the age of industry 4.0, laser technology is firmly established within manufacturing. A wide variety of laser techniques – from USP ablation and additive...

All Focus news of the innovation-report >>>

Anzeige

Anzeige

Event News

Laser use for neurosurgery and biofabrication - LaserForum 2016 focuses on medical technology

27.09.2016 | Event News

Experts from industry and academia discuss the future mobile telecommunications standard 5G

23.09.2016 | Event News

ICPE in Graz for the seventh time

20.09.2016 | Event News

 
Latest News

New switch decides between genome repair and death of cells

27.09.2016 | Life Sciences

Nanotechnology for energy materials: Electrodes like leaf veins

27.09.2016 | Physics and Astronomy

‘Missing link’ found in the development of bioelectronic medicines

27.09.2016 | Life Sciences

VideoLinks
B2B-VideoLinks
More VideoLinks >>>