The published research has helped to advance medical understanding of how the body defends against disease and heals itself.
The study also reveals that the same protein, Properdin –discovered only half a century ago- can also harm internal organs under certain circumstances.
Lack of the protein in the human body has previously been linked to susceptibility to meningitis.
But the new findings by Dr Cordula Stover, of the Department of Infection, Immunity and Inflammation at the University of Leicester assign hitherto unappreciated importance to this protein of the immune defence.
Her work, funded by the Medical Research Council (MRC), is published in the form of two papers in the Journal of Immunology. It is being published in print on May 15.
Dr Stover, a Lecturer in Immunology, said: “I have a broad interest in immune mechanisms of health and disease, though recently, I have focused on a particular component of the first line immune defence, a protein called Properdin.
“Properdin deficiency in families, though rare, predisposes people to develop meningococcal meningitis, usually with poor outcome of the infection.
“I hypothesised that the importance of Properdin extends beyond this particular infectious disease, and that indeed it is an important player in health generally, and that its importance becomes apparent in conditions involving both acute and chronic states of inflammation.
“I was most delighted to obtain funding from the MRC to investigate this.”
Now two of Dr Stover’s papers, published in the Journal of Immunology, demonstrate that Properdin plays a significant role in the survival of conditions relating to surgical perforation of the gut and activation of the immune system by wall components of bacteria.
In conditions relating to multi-organ dysfunction, a complication which can occur in response to severe sepsis, Properdin however aggravates organ damage.
Dr Stover added: “So far, the system Properdin is a part of - the so-called complement system - is classified as a first line, innate, acutely effective immune activation mechanism.
“My work shows that the activity of Properdin extends beyond the acute phase and, importantly, that Properdin is stepping onto the stage as an important player in different inflammatory conditions.
“As the worldwide burden of chronic inflammatory disease increases, it is of practical relevance to understand the contribution of this immune protein.”
· The history of Properdin extends about 50 years with the first significant biochemical characterisations made in the USA, however, subsequently, the UK has contributed tremendously with the characterisation of the Properdin gene and structural modelling of the Properdin protein.
New malaria analysis method reveals disease severity in minutes
14.08.2017 | University of British Columbia
New type of blood cells work as indicators of autoimmunity
14.08.2017 | Instituto de Medicina Molecular
Whether you call it effervescent, fizzy, or sparkling, carbonated water is making a comeback as a beverage. Aside from quenching thirst, researchers at the University of Illinois at Urbana-Champaign have discovered a new use for these "bubbly" concoctions that will have major impact on the manufacturer of the world's thinnest, flattest, and one most useful materials -- graphene.
As graphene's popularity grows as an advanced "wonder" material, the speed and quality at which it can be manufactured will be paramount. With that in mind,...
Physicists at the University of Bonn have managed to create optical hollows and more complex patterns into which the light of a Bose-Einstein condensate flows. The creation of such highly low-loss structures for light is a prerequisite for complex light circuits, such as for quantum information processing for a new generation of computers. The researchers are now presenting their results in the journal Nature Photonics.
Light particles (photons) occur as tiny, indivisible portions. Many thousands of these light portions can be merged to form a single super-photon if they are...
For the first time, scientists have shown that circular RNA is linked to brain function. When a RNA molecule called Cdr1as was deleted from the genome of mice, the animals had problems filtering out unnecessary information – like patients suffering from neuropsychiatric disorders.
While hundreds of circular RNAs (circRNAs) are abundant in mammalian brains, one big question has remained unanswered: What are they actually good for? In the...
An experimental small satellite has successfully collected and delivered data on a key measurement for predicting changes in Earth's climate.
The Radiometer Assessment using Vertically Aligned Nanotubes (RAVAN) CubeSat was launched into low-Earth orbit on Nov. 11, 2016, in order to test new...
A study led by scientists of the Max Planck Institute for the Structure and Dynamics of Matter (MPSD) at the Center for Free-Electron Laser Science in Hamburg presents evidence of the coexistence of superconductivity and “charge-density-waves” in compounds of the poorly-studied family of bismuthates. This observation opens up new perspectives for a deeper understanding of the phenomenon of high-temperature superconductivity, a topic which is at the core of condensed matter research since more than 30 years. The paper by Nicoletti et al has been published in the PNAS.
Since the beginning of the 20th century, superconductivity had been observed in some metals at temperatures only a few degrees above the absolute zero (minus...
16.08.2017 | Event News
04.08.2017 | Event News
26.07.2017 | Event News
18.08.2017 | Life Sciences
18.08.2017 | Physics and Astronomy
18.08.2017 | Materials Sciences