A lot of diseases are known to the medical science, each of the diseases having its own symptoms. Nevertheless, all diseases have something in common, regardless of the illness cause and the patients` individual reactions. These generalised regularities inherent in all diseases are called general pathology. Physicians can easily recognise anatomical and physiological abnormalities, but some symptoms are not evident. These abnormalities appear to be a presage of a disease, and after the recovery they are retained for some time by the organism as a reminder of the disease. The signs of such asymptomatic pathology are, brought to light, with the help of biochemical, immunological, biophysical, molecular-biological and molecular-genetic research. For twenty years the staff of the Medical Genetic Research Center (Russian Academy of Medical Sciences) have been researching various latent signs of general pathology comparing the value of information they carry. The scientists have come to the conclusion that some, specific leukocytes` proteins are more sensitive.
The leukocytes genome reacts violently to the pathological state of the organism, as a result it changes the content of proteins called 53? and 43? in these cells. In fact, the indication of general illness is the ratio of these proteins content to the content of the histon protein of leukocytes. The scientists have examined 1,672 patients suffering from different types of various diseases, both heritable and acquired, including phenylketonuria, Down`s syndrome, psoriasis, stomach ulcer, bronchial asthma, oncological diseases, hepatitis, herpes, tuberculosis and many others. The researchers have also focused on the radiation sickness, cardiovascular diseases, illnesses of kidneys, liver and bile-ducts, tumours, diseases of bones and joints and gastrointestinal tract. Without exception, the ratio of proteins of all the examined patients has turned out abnormal. This implies high probability diagnostics - nobody has managed yet to achieve one-hundred-percent diagnostics.
Up to now the pre-clinical diagnostics used other indications, for instance, the scientists determined the concentration of various cell types or the content of antibodies and some other substances in blood. However, these indications may fail the diagnostics as they do not show up with all diseases or with all patients. The 53K and 43K proteins relative content has never failed the researchers. There exist other signs of general pathology, which can be determined by a physician. These signs can include oedema, pathologies of blood circulation, thrombosis, inflammation and some others. However, it is not easy to use these signs for the early diagnostics purposes, since with different individuals and at different phases of illness development these signs do not only reflect the pathological process but also indicate the adaptive response of the organism.
Natalia Reznik | alfa
Investigators may unlock mystery of how staph cells dodge the body's immune system
22.09.2017 | Cedars-Sinai Medical Center
Monitoring the heart's mitochondria to predict cardiac arrest?
21.09.2017 | Boston Children's Hospital
Plants and algae use the enzyme Rubisco to fix carbon dioxide, removing it from the atmosphere and converting it into biomass. Algae have figured out a way to increase the efficiency of carbon fixation. They gather most of their Rubisco into a ball-shaped microcompartment called the pyrenoid, which they flood with a high local concentration of carbon dioxide. A team of scientists at Princeton University, the Carnegie Institution for Science, Stanford University and the Max Plank Institute of Biochemistry have unravelled the mysteries of how the pyrenoid is assembled. These insights can help to engineer crops that remove more carbon dioxide from the atmosphere while producing more food.
A warming planet
Our brains house extremely complex neuronal circuits, whose detailed structures are still largely unknown. This is especially true for the so-called cerebral cortex of mammals, where among other things vision, thoughts or spatial orientation are being computed. Here the rules by which nerve cells are connected to each other are only partly understood. A team of scientists around Moritz Helmstaedter at the Frankfiurt Max Planck Institute for Brain Research and Helene Schmidt (Humboldt University in Berlin) have now discovered a surprisingly precise nerve cell connectivity pattern in the part of the cerebral cortex that is responsible for orienting the individual animal or human in space.
The researchers report online in Nature (Schmidt et al., 2017. Axonal synapse sorting in medial entorhinal cortex, DOI: 10.1038/nature24005) that synapses in...
Whispering gallery mode (WGM) resonators are used to make tiny micro-lasers, sensors, switches, routers and other devices. These tiny structures rely on a...
Using ultrafast flashes of laser and x-ray radiation, scientists at the Max Planck Institute of Quantum Optics (Garching, Germany) took snapshots of the briefest electron motion inside a solid material to date. The electron motion lasted only 750 billionths of the billionth of a second before it fainted, setting a new record of human capability to capture ultrafast processes inside solids!
When x-rays shine onto solid materials or large molecules, an electron is pushed away from its original place near the nucleus of the atom, leaving a hole...
For the first time, physicists have successfully imaged spiral magnetic ordering in a multiferroic material. These materials are considered highly promising candidates for future data storage media. The researchers were able to prove their findings using unique quantum sensors that were developed at Basel University and that can analyze electromagnetic fields on the nanometer scale. The results – obtained by scientists from the University of Basel’s Department of Physics, the Swiss Nanoscience Institute, the University of Montpellier and several laboratories from University Paris-Saclay – were recently published in the journal Nature.
Multiferroics are materials that simultaneously react to electric and magnetic fields. These two properties are rarely found together, and their combined...
19.09.2017 | Event News
12.09.2017 | Event News
06.09.2017 | Event News
22.09.2017 | Life Sciences
22.09.2017 | Medical Engineering
22.09.2017 | Physics and Astronomy