With funding from the Biotechnology and Biological Sciences Research Council (BBSRC) neurobiologists from the Institute of Psychiatry and tissue engineers from The University of Nottingham have joined forces to tackle the challenge of tissue loss as a result of stroke.
Speaking at the conference in Edinburgh, Dr Mike Modo from the Institute of Psychiatry will explain how combining scaffold microparticles with neural stem cells (NSCs) could regenerate lost brain tissue.
Strokes cause temporary loss of blood supply to the brain which results in areas of brain tissue dying — causing loss of bodily functions such as speech and movement. Neural Stem Cells offer exciting possibilities for tissue regeneration, but there are currently major limitations in delivering these cells to the brain. And while NSC transplantation has been proven to improve functional outcomes in rats with stroke damage little reduction in lesion volume has been observed.
The research is being carried out by Dr Mike Modo and Professor Jack Price from the Institute of Psychiatry and Professor Kevin Shakesheff from The University of Nottingham.
Their findings are being presented at the UK National Stem Cell Network Inaugural Science Meeting at the Edinburgh Conference Centre on 10 April 2008. The conference is a showcase of the best and latest UK stem cell science across all stem cell disciplines.
Working with rats, Dr Modo and his team are developing cell-scaffold combinations that could be injected into the brain to provide a framework inside the cavities caused by stroke so that the cells are held there until they can work their way to connect with surrounding healthy tissue.
Dr Modo explains: "We propose that using scaffold particles could support NSCs in the cavity to re-form the lost tissue and provide a more complete functional repair. The ultimate aim is to establish if this approach can provide a more efficient and effective repair process in stroke."
Kevin Shakesheff, Director of The University of Nottingham's new £25m Centre for Biomolecular Sciences and Professor of Tissue Engineering in the School of Pharmacy, said: “Within the body our cells function within tightly controlled 3D architectures. Our scaffolds can recreate some of the architectural features and thereby protect the cells and help them to integrate and function."
The team hope their work will pave the way for NSCs to be successfully used in clinical settings to re-develop parts of the brain damaged by stroke and neurodegenerative diseases.
The end of pneumonia? New vaccine offers hope
23.10.2017 | University at Buffalo
Scientists track ovarian cancers to site of origin: Fallopian tubes
23.10.2017 | Johns Hopkins Medicine
Salmonellae are dangerous pathogens that enter the body via contaminated food and can cause severe infections. But these bacteria are also known to target...
University of Maryland researchers contribute to historic detection of gravitational waves and light created by event
On August 17, 2017, at 12:41:04 UTC, scientists made the first direct observation of a merger between two neutron stars--the dense, collapsed cores that remain...
Seven new papers describe the first-ever detection of light from a gravitational wave source. The event, caused by two neutron stars colliding and merging together, was dubbed GW170817 because it sent ripples through space-time that reached Earth on 2017 August 17. Around the world, hundreds of excited astronomers mobilized quickly and were able to observe the event using numerous telescopes, providing a wealth of new data.
Previous detections of gravitational waves have all involved the merger of two black holes, a feat that won the 2017 Nobel Prize in Physics earlier this month....
Material defects in end products can quickly result in failures in many areas of industry, and have a massive impact on the safe use of their products. This is why, in the field of quality assurance, intelligent, nondestructive sensor systems play a key role. They allow testing components and parts in a rapid and cost-efficient manner without destroying the actual product or changing its surface. Experts from the Fraunhofer IZFP in Saarbrücken will be presenting two exhibits at the Blechexpo in Stuttgart from 7–10 November 2017 that allow fast, reliable, and automated characterization of materials and detection of defects (Hall 5, Booth 5306).
When quality testing uses time-consuming destructive test methods, it can result in enormous costs due to damaging or destroying the products. And given that...
Using a new cooling technique MPQ scientists succeed at observing collisions in a dense beam of cold and slow dipolar molecules.
How do chemical reactions proceed at extremely low temperatures? The answer requires the investigation of molecular samples that are cold, dense, and slow at...
23.10.2017 | Event News
17.10.2017 | Event News
10.10.2017 | Event News
23.10.2017 | Life Sciences
23.10.2017 | Physics and Astronomy
23.10.2017 | Health and Medicine