At the International conference “Invasion and Metastasis” held at the Max Delbrück Center for Molecular Medicine (MDC) in Berlin, Dr. David DeNardo from the laboratory of Professor Lisa Coussens from the University of California, San Francisco, USA reported on how tumours use immune cells to grow faster and disseminate in the body.
When germs infiltrate a wound after injury, the body can well defend itself. Immune cells recognize the pathogens and initiate inflammation to limit infection. Attracted by this warning, many different cells of the immune system migrate to the centre of inflammation to help fight off the intruders. The injured area gets hot and red and becomes more sensitive and swollen. When the healing process is completed, inflammation abates and the immune cells withdraw. When some types of immune cells encounter tumour cells, they can also cause inflammation. Compared to normal injury, however, these immune cells often do not withdraw, but rather generate an enduring, chronic inflammation. “Therefore, we call tumours wounds that never heal,” Dr. DeNardo illustrated.
During the healing process, the immune cells attracted to a wound not only combat the invaders, but also produce growth factors and so-called proteases, enzymes that remodel the connective structures between cells. In addition, new blood vessels are formed to provide the injured tissue with oxygen and nutrients. This formation of new blood vessels is known as angiogenesis. „Normally these mechanisms enhance sealing of the wound,” Dr. DeNardo said. “However, cancer cells exploit them for their own interests.”
Growth factors permit tumour cells to continue proliferating when proteases remodel the connective structures between cells and thus enable single cancer cells to disseminate from the original tumour. However, angiogenesis also helps metastases, the dangerous daughters of a primary tumour, to form. The new blood vessels grant single disseminated cancer cells access to the bloodstream much faster.
“Scientists are trying to develop strategies to stop these processes of inflammation and this way,” Dr. DeNardo hopes, “help cancer patients.” It has already been shown that some cancer metastases develop more rarely in patients who regularly take acetylsalicylic acid. This substance inhibits inflammation and thus blocks the processes cancer uses to grow and spread.
Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München
Second cause of hidden hearing loss identified
20.02.2017 | Michigan Medicine - University of Michigan
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
Nanometer-scale magnetic perforated grids could create new possibilities for computing. Together with international colleagues, scientists from the Helmholtz Zentrum Dresden-Rossendorf (HZDR) have shown how a cobalt grid can be reliably programmed at room temperature. In addition they discovered that for every hole ("antidot") three magnetic states can be configured. The results have been published in the journal "Scientific Reports".
Physicist Dr. Rantej Bali from the HZDR, together with scientists from Singapore and Australia, designed a special grid structure in a thin layer of cobalt in...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
22.02.2017 | Power and Electrical Engineering
22.02.2017 | Life Sciences
22.02.2017 | Physics and Astronomy