Researchers at The Hospital for Sick Children (HSC), the University Health Network (UHN), and the University of Toronto (U of T) have identified a novel gene that when mutated results in medulloblastoma, the most common malignant brain tumour found in children. This research is reported in the July issue of the scientific journal Nature Genetics.
Brain tumours are the second most common cancer in children after leukemia, with the incidence increasing at a rate of five to 10 per cent per year. More than 200 Canadian children are diagnosed with brain tumours each year, with approximately 100 new cases at The Hospital for Sick Children alone. Despite advances in treatment, survival from brain tumours remains lower than for other forms of cancer. Medulloblastoma, a malignant tumour that occurs in the cerebellum, accounts for 20 per cent of all paediatric brain tumours. It is a rapidly growing tumour that is more common in boys than girls.
"A subset of children with medulloblastoma are born with a mutation in a gene called SUFU, or human suppressor of fused, that predisposes them to develop this tumour. This is a germline mutation - the mutation is in every cell of the childs body - which indicates that this gene is important in the initiation of the tumour," said Dr. Michael Taylor, the studys lead author, a U of T graduate student, and a neurosurgery resident in HSCs Clinician-Scientist Training Program.
Laura Greer | EurrekAlert
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An international team of researchers has discovered a new anti-cancer protein. The protein, called LHPP, prevents the uncontrolled proliferation of cancer cells in the liver. The researchers led by Prof. Michael N. Hall from the Biozentrum, University of Basel, report in “Nature” that LHPP can also serve as a biomarker for the diagnosis and prognosis of liver cancer.
The incidence of liver cancer, also known as hepatocellular carcinoma, is steadily increasing. In the last twenty years, the number of cases has almost doubled...
In just a few weeks from now, the Chinese space station Tiangong-1 will re-enter the Earth's atmosphere where it will to a large extent burn up. It is possible that some debris will reach the Earth's surface. Tiangong-1 is orbiting the Earth uncontrolled at a speed of approx. 29,000 km/h.Currently the prognosis relating to the time of impact currently lies within a window of several days. The scientists at Fraunhofer FHR have already been monitoring Tiangong-1 for a number of weeks with their TIRA system, one of the most powerful space observation radars in the world, with a view to supporting the German Space Situational Awareness Center and the ESA with their re-entry forecasts.
Following the loss of radio contact with Tiangong-1 in 2016 and due to the low orbital height, it is now inevitable that the Chinese space station will...
Fraunhofer Institute for Organic Electronics, Electron Beam and Plasma Technology FEP, provider of research and development services for OLED lighting solutions, announces the founding of the “OLED Licht Forum” and presents latest OLED design and lighting solutions during light+building, from March 18th – 23rd, 2018 in Frankfurt a.M./Germany, at booth no. F91 in Hall 4.0.
They are united in their passion for OLED (organic light emitting diodes) lighting with all of its unique facets and application possibilities. Thus experts in...
A new scenario seeking to explain how Mars' putative oceans came and went over the last 4 billion years implies that the oceans formed several hundred million...
For the first time, an interdisciplinary team from the University of Basel has succeeded in integrating artificial organelles into the cells of live zebrafish embryos. This innovative approach using artificial organelles as cellular implants offers new potential in treating a range of diseases, as the authors report in an article published in Nature Communications.
In the cells of higher organisms, organelles such as the nucleus or mitochondria perform a range of complex functions necessary for life. In the networks of...
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