Researchers at The Hospital for Sick Children (HSC), the University Health Network (UHN), and the University of Toronto (U of T) have identified a novel gene that when mutated results in medulloblastoma, the most common malignant brain tumour found in children. This research is reported in the July issue of the scientific journal Nature Genetics.
Brain tumours are the second most common cancer in children after leukemia, with the incidence increasing at a rate of five to 10 per cent per year. More than 200 Canadian children are diagnosed with brain tumours each year, with approximately 100 new cases at The Hospital for Sick Children alone. Despite advances in treatment, survival from brain tumours remains lower than for other forms of cancer. Medulloblastoma, a malignant tumour that occurs in the cerebellum, accounts for 20 per cent of all paediatric brain tumours. It is a rapidly growing tumour that is more common in boys than girls.
"A subset of children with medulloblastoma are born with a mutation in a gene called SUFU, or human suppressor of fused, that predisposes them to develop this tumour. This is a germline mutation - the mutation is in every cell of the childs body - which indicates that this gene is important in the initiation of the tumour," said Dr. Michael Taylor, the studys lead author, a U of T graduate student, and a neurosurgery resident in HSCs Clinician-Scientist Training Program.
Laura Greer | EurrekAlert
Organ-on-a-chip mimics heart's biomechanical properties
23.02.2017 | Vanderbilt University
Researchers identify cause of hereditary skeletal muscle disorder
22.02.2017 | Klinikum der Universität München
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded after a glide flight with an Airbus A320 in ditching on the Hudson River. All 155 people on board were saved.
On January 15, 2009, Chesley B. Sullenberger was celebrated world-wide: after the two engines had failed due to bird strike, he and his flight crew succeeded...
Cells need to repair damaged DNA in our genes to prevent the development of cancer and other diseases. Our cells therefore activate and send “repair-proteins”...
The Fraunhofer IWS Dresden and Technische Universität Dresden inaugurated their jointly operated Center for Additive Manufacturing Dresden (AMCD) with a festive ceremony on February 7, 2017. Scientists from various disciplines perform research on materials, additive manufacturing processes and innovative technologies, which build up components in a layer by layer process. This technology opens up new horizons for component design and combinations of functions. For example during fabrication, electrical conductors and sensors are already able to be additively manufactured into components. They provide information about stress conditions of a product during operation.
The 3D-printing technology, or additive manufacturing as it is often called, has long made the step out of scientific research laboratories into industrial...
Nature does amazing things with limited design materials. Grass, for example, can support its own weight, resist strong wind loads, and recover after being...
13.02.2017 | Event News
10.02.2017 | Event News
09.02.2017 | Event News
27.02.2017 | Materials Sciences
27.02.2017 | Interdisciplinary Research
27.02.2017 | Life Sciences